全文获取类型
收费全文 | 27184篇 |
免费 | 858篇 |
国内免费 | 157篇 |
专业分类
化学 | 18211篇 |
晶体学 | 255篇 |
力学 | 926篇 |
综合类 | 1篇 |
数学 | 2346篇 |
物理学 | 6460篇 |
出版年
2023年 | 154篇 |
2022年 | 410篇 |
2021年 | 491篇 |
2020年 | 432篇 |
2019年 | 448篇 |
2018年 | 333篇 |
2017年 | 317篇 |
2016年 | 727篇 |
2015年 | 631篇 |
2014年 | 793篇 |
2013年 | 1489篇 |
2012年 | 1947篇 |
2011年 | 2135篇 |
2010年 | 1295篇 |
2009年 | 1143篇 |
2008年 | 1741篇 |
2007年 | 1641篇 |
2006年 | 1532篇 |
2005年 | 1428篇 |
2004年 | 1262篇 |
2003年 | 982篇 |
2002年 | 967篇 |
2001年 | 672篇 |
2000年 | 575篇 |
1999年 | 338篇 |
1998年 | 252篇 |
1997年 | 293篇 |
1996年 | 334篇 |
1995年 | 257篇 |
1994年 | 274篇 |
1993年 | 276篇 |
1992年 | 264篇 |
1991年 | 204篇 |
1990年 | 154篇 |
1989年 | 139篇 |
1988年 | 140篇 |
1987年 | 118篇 |
1986年 | 95篇 |
1985年 | 168篇 |
1984年 | 112篇 |
1983年 | 97篇 |
1982年 | 122篇 |
1981年 | 88篇 |
1980年 | 79篇 |
1978年 | 80篇 |
1977年 | 85篇 |
1976年 | 94篇 |
1975年 | 101篇 |
1974年 | 79篇 |
1973年 | 102篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
871.
Sangho Lee Jin-Woo Lee Sejoong Kim Pyung-Kyu Park Jae-Hyuk Kim Chung-Hak Lee 《Journal of membrane science》2009
The removal of 17β-estradiol (E2) was investigated in a powdered activated carbon-submerged microfiltration (PAC-MF) hybrid system to better understand the effect on the system performance of PAC deposition on the membrane. A series of experiments were carried out under various operating conditions. Although the rejection or adsorption of E2 by MF membrane itself was almost negligible, the concentration of E2 in the permeate was always lower than it was in the reactor. This is because E2 was further removed as it passed through the PAC layer deposited on the membrane. As the E2 removal efficiency by the deposited PAC was lower than that by the PAC in the bulk phase, the overall E2 removal was largely dependent on the fraction of the deposited PAC on the membrane which were influenced by operating parameters such as permeate flux, hydraulic retention time (HRT) and mixing intensity in a PAC-MF system. The effect of these parameters on the overall E2 removal rate were also determined quantitatively using model equations developed in this study. 相似文献
872.
Young Hee Choi Young Sun Lee Tae Kon Kim Guang-Jin Im Bong-Yong Lee Myung Gull Lee 《Chromatographia》2009,69(7-8):677-683
A simple, rapid, and reproducible isocratic reversed-phase LC method has been established for simultaneous analysis of mirodenafil and its two main metabolites, SK3541 and SK3544, in rat plasma, urine, and tissue homogenates. Samples were deproteinized with acetonitrile containing sildenafil (internal standard). The compounds were separated on a C18 column with 52:48 (v/v) 0.02 m ammonium acetate buffer (pH 6)—acetonitrile as mobile phase at a flow rate of 1.4 mL min?1. UV detection was at 254 nm and detection limits of mirodenafil, SK3541, and SK3544 in plasma were 0.03, 0.05, and 0.1 μg mL?1, respectively. The method is applicable to pharmacokinetic studies of mirodenafil and its metabolites in rats. 相似文献
873.
Yong‐beom Lim Dr. Myongsoo Lee Prof. 《Angewandte Chemie (International ed. in English)》2009,48(19):3394-3396
Available in small print : Block copolymer lithography has great potential for reducing the size and fabrication time of integrated circuits. Hydrogen‐bonding‐mediated molecular recognition in self‐assembly processes can be used to produce highly ordered square arrays of block copolymers on the surface of a silicon substrate (see picture).
874.
875.
Ji-Eun Lee Hyonchol Jang Eun-Jung Cho Hong-Duk Youn 《Experimental & molecular medicine》2009,41(7):471-477
Down syndrome critical region 1 (DSCR1), an oxidative stress-response gene, interacts with calcineurin and represses its phosphatase activity. Recently it was shown that hydrogen peroxide inactivates calcineurin by proteolytic cleavage. Based on these facts, we investigated whether oxidative stress affects DSCR1-mediated inactivation of calcineurin. We determined that overexpression of DSCR1 leads to increased proteolytic cleavage of calcineurin. Convertsely, knockdown of DSCR1 abolished calcineurin cleavage upon treatment with hydrogen peroxide. The PXIIXT motif in the COOH-terminus of DSCR1 is responsible for both binding and cleavage of calcineurin. The knockdown of overexpressed DSCR1 in DS fibroblast cells also abrogated calcineurin proteolysis by hydrogen peroxide. These results suggest that DSCR1 has the ability to inactivate calcineurin by inducing proteolytic cleavage of calcineurin upon oxidative stress. 相似文献
876.
Young Jun Koh Byung-Hyun Park Ji-Hyun Park Jinah Han In-Kyu Lee Jin Woo Park Gou Young Koh 《Experimental & molecular medicine》2009,41(12):880-895
We sought to determine the effects of activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) on multilocularization of adipocytes in adult white adipose tissue (WAT). Male C57BL/6 normal, db/db, and ob/ob mice were treated with agonists of PPAR-γ, PPAR-α, or β3-adrenoceptor for 3 weeks. To distinguish multilocular adipocytes from unilocular adipocytes, whole-mounted adipose tissues were co-immunostained for perilipin and collagen IV. PPAR-γ activation with rosiglitazone or pioglitazone induced a profound change of unilocular adipocytes into smaller, multilocular adipocytes in adult WAT in a time-dependent, dose-dependent, and reversible manner. PPAR-α activation with fenofibrate did not affect the number of locules or remodeling. db/db and ob/ob obese mice exhibited less multilocularization in response to PPAR-γ activation compared to normal mice. Nevertheless, all adipocytes activated by PPAR-γ contained a single nucleus regardless of locule number. Multilocular adipocytes induced by PPAR-γ activation contained substantially increased mitochondrial content and enhanced expression of uncoupling protein-1, PPAR-γ coactivator-1-α , and perilipin. Taken together, PPAR-γ activation induces profound multilocularization and enhanced mitochondrial biogenesis in the adipocytes of adult WAT. These changes may affect the overall function of WAT. 相似文献
877.
878.
Lee S Park J Ragan R Kim S Lee Z Lim do K Ohlberg DA Williams RS 《Journal of the American Chemical Society》2006,128(17):5745-5750
Self-assembled monolayers (SAMs) of octanethiol and benzeneethanethiol were deposited on clean Pt(111) surfaces in ultrahigh vacuum (UHV). Highly resolved images of these SAMs produced by an in situ scanning tunneling microscope (STM) showed that both systems organize into a super-structure mosaic of domains of locally ordered, closely packed molecules. Analysis of the STM images indicated a (square root 3 x square root 3)R30 degrees unit cell for the octanethiol SAMs and a 4(square root 3 x square root 3)R30 degrees periodicity based on 2 x 2 basic molecular packing for the benzeneethanethiol SAMs under the coverage conditions investigated. SAMs on Pt(111) exhibited differences in molecular packing and a lower density of disordered regions than SAMs on Au(111). Electron transport measurements were performed using scanning tunneling spectroscopy. Benzeneethanethiol/Pt(111) junctions exhibited a higher conductance than octanethiol/Pt(111) junctions. 相似文献
879.
Hill MR Lee EY Russell JJ Wang Y Lamb RN 《The journal of physical chemistry. B》2006,110(18):9236-9240
Magnesium oxide thin films have been deposited with use of single source chemical vapor deposition (SSCVD). The resultant films were examined by using transmission electron microscopy, X-ray texture analysis, and pole figure analysis. Due to the nature of the chemical reactions occurring at the surface during SSCVD growth, which result in a high growth rate/low flux environment, films of (111) orientation have been achieved without an amorphous underlayer, an unusual result for films of this orientation. Moreover the films have a strong degree of biaxial texturing in the x-y plane as found with X-ray texture analysis. These findings have important implications for buffer layers in perovskite thin film devices. The mechanism producing these structures has been revealed by using TEM and is discussed here. 相似文献
880.
Stabilization of gamma-alumina suspension for chemical-mechanical polishing (CMP) of copper was investigated. Citric acid and poly(acrylic acid) (PAA) (M(w)=5000) were used as dispersant. The stability of suspension was evaluated from the changes in viscosity, particle size and zeta potential. It appears that metastable gamma-alumina mainly due to its high specific surface area and to the presence of aluminol groups on its surface is progressively transformed to bayerite (beta-Al(OH)(3)) by hydration procedure. Citric acid molecules were adsorbed onto gamma-alumina surface effectively and exhibited the excellent hydration inhibition effect. Although citrate-alumina surface complexes give barrier to the flocculation, the repulsion potential is based mainly on the electrostatic repulsion, thereby steric hindrance caused by the adsorption of these small molecules is very weak. The electrosteric repulsion, which provides more effective dispersion stability than electrostatic repulsion force, can be expected by using polyelectrolyte such as PAA; however, adsorbed layers of PAA onto solid/liquid interface are loosely formed. Therefore, a large amount of PAA was required to inhibit the surface hydration of gamma-alumina suspension, thereby the excess addition of PAA decreased the electrosteric repulsion and re-bridging of the dispersant between particles caused an increase in suspension viscosity. Therefore, synergistic effect can be expected in mixed dispersant system of citric acid and PAA, since small citric acid molecules are adsorbed faster than PAA, inhibiting the progress of surface hydration, and then adsorbed PAA layers exhibit the effective electrosteric repulsion interaction between particles with a small amount compared with PAA alone. It was revealed that the gamma-alumina slurry dispersed by mixed dispersant exhibited the improved removal rate of Cu layer by CMP polishing test. 相似文献