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911.
Daewha Hong KiEun Bae Dr. Duckshin Park Houngkyung Kim Seok‐Pyo Hong Mi‐Hee Kim Dr. Bong Soo Lee Dr. Sangwon Ko Prof. Dr. Seokwoo Jeon Xu Zheng Prof. Dr. Wan Soo Yun Prof. Dr. Yang‐Gyun Kim Prof. Dr. Insung S. Choi Prof. Dr. Jungkyu K. Lee 《化学:亚洲杂志》2015,10(3):568-571
Direct patterning of streptavidin and NIH 3T3 fibroblast cells was successfully achieved over a large‐area pristine graphene sheet on Si/SiO2 by aryl azide‐based photografting with the conventional UV lithographic technique and surface‐initiated, atom transfer radical polymerization of oligo(ethylene glycol) methacrylate. 相似文献
912.
De Novo Design and Synthesis of a γ‐Turn Peptidomimetic Scaffold and Its Application as JNK3 Allosteric Ligand
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As a way to develop a neuroprotective agent for the JNK3‐JIP1‐binding site, peptidomimetics of JIP‐1 as JNK3 allosteric regulators have been examined. The study consisted of in silico scaffold hopping, molecular docking, solution and solid‐phase peptide syntheses, and Kd measurements using surface plasmon resonance. As a peptidomimetic of JIP1, heptamer mimetic 16 (Kd=2.72 μm ) displayed a higher affinity than decamer JIP1 (Kd=23.6 μm ). The high affinity of 16 implies that the characteristic γ‐turn mimetic structure, “”Φ‐X‐Φ“ hydrophobic motif in 16 , increased its affinity toward the JIP‐site of JNK3. 相似文献
913.
Iron(III)‐Selective Chelation‐Enhanced Fluorescence Sensing for In Vivo Imaging Applications
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Lin E. Guo Xin Yi Liu Huan Wang Qiu Ling Chen Guang Ke Wang Prof. Kaijun Luo Qi Li Mi Prof. Ying Zhou Jun Feng Zhang 《化学:亚洲杂志》2015,10(9):1898-1902
A “turn‐on” pattern Fe3+‐selective fluorescent sensor was synthesized and characterized that showed high fluorescence discrimination of Fe3+ over Fe2+ and other tested ions. With a 62‐fold fluorescence enhancement towards Fe3+, the probe was employed to detect Fe3+ in vivo in HeLa cells and Caenorhabditis elegans, and it was also successfully used to elucidate Fe3+ enrichment and exchange infected by innexin3 (Inx3) in hemichannel‐closed Sf9 cells. 相似文献
914.
Hoyeon Lee Soojin Uhm Jung‐Won Shin Hyun Mi Jeon Sun Dongbang Hyo Sung Jung Yun‐Cheol Na Prof. Chulhun Kang Prof. Jong Seung Kim 《化学:亚洲杂志》2015,10(12):2695-2700
A galactose‐appended drug delivery system released camptothecin (CPT) to lysosomes of HepG2 hepatoma cells, resulting in the cell resistance to the anticancer drug. We found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy. 相似文献
915.
916.
Lei Li Yunpeng Liu Cheng Ma Jingyao Qu Angie D. Calderon Baolin Wu Na Wei Xuan Wang Yuxi Guo Zhongying Xiao Jing Song Go Sugiarto Yanhong Li Hai Yu Xi Chen Peng George Wang 《Chemical science》2015,6(10):5652-5661
Quantification, characterization and biofunctional studies of N-glycans on proteins remain challenging tasks due to the complexity, diversity and low abundance of these glycans. The availability of structurally defined N-glycan (especially isomer) libraries is essential to help solve these tasks. We report herein an efficient chemoenzymatic strategy, namely Core Synthesis/Enzymatic Extension (CSEE), for rapid production of diverse N-glycans. Starting with 5 chemically prepared building blocks, 8 N-glycan core structures containing one or two terminal N-acetyl-d-glucosamine (GlcNAc) residue(s) were chemically synthesized via consistent use of oligosaccharyl thioethers as glycosylation donors in a convergent fragment coupling strategy. Each of these core structures was then extended to 5 to 15 N-glycan sequences by enzymatic reactions catalyzed by 4 robust glycosyltransferases. Success in synthesizing N-glycans with Neu5Gc and core-fucosylation further expanded the ability of the enzymatic extension. Meanwhile, high performance liquid chromatography with an amide column enabled rapid and efficient purification (>98% purity) of N-glycans in milligram scales. A total of 73 N-glycans (63 isomers) were successfully prepared and characterized by MS2 and NMR. In summary, the CSEE strategy provides a practical approach for “mass production” of structurally defined N-glycans, which are important standards and probes for glycoscience. 相似文献
917.
Ye Ji Kim Sun Min Kim Eun Jin Cho Hideo Hosono Jung Woon Yang Sung Wng Kim 《Chemical science》2015,6(6):3577-3581
A simple and highly efficient transfer hydrogenation of alkynes and alkenes by using a two-dimensional electride, dicalcium nitride ([Ca2N]+·e–), as an electron transfer agent is disclosed. Excellent yields in the transformation are attributed to the remarkable electron transfer efficiency in the electride-mediated reactions. It is clarified that an effective discharge of electrons from the [Ca2N]+·e– electride in alcoholic solvents is achieved by the decomposition of the electride via alcoholysis and the generation of ammonia and Ca(OiPr)2. We found that the choice of solvent was crucial for enhancing the electron transfer efficiency, and a maximum efficiency of 80% was achieved by using a DMF mixed isopropanol co-solvent system. This is the highest value reported to date among single electron transfer agents in the reduction of C–C multiple bonds. The observed reactivity and efficiency establish that electrides with a high density of anionic electrons can readily participate in the reduction of organic functional groups. 相似文献
918.
919.
Rücktitelbild: Cofactor‐Free Light‐Driven Whole‐Cell Cytochrome P450 Catalysis (Angew. Chem. 3/2015)
920.