全文获取类型
收费全文 | 852篇 |
免费 | 2篇 |
国内免费 | 4篇 |
专业分类
化学 | 627篇 |
晶体学 | 6篇 |
力学 | 29篇 |
数学 | 91篇 |
物理学 | 105篇 |
出版年
2023年 | 7篇 |
2022年 | 7篇 |
2021年 | 7篇 |
2020年 | 7篇 |
2019年 | 4篇 |
2016年 | 4篇 |
2015年 | 7篇 |
2014年 | 6篇 |
2013年 | 31篇 |
2012年 | 36篇 |
2011年 | 53篇 |
2010年 | 22篇 |
2009年 | 16篇 |
2008年 | 49篇 |
2007年 | 61篇 |
2006年 | 51篇 |
2005年 | 49篇 |
2004年 | 63篇 |
2003年 | 44篇 |
2002年 | 36篇 |
2001年 | 8篇 |
2000年 | 5篇 |
1999年 | 11篇 |
1998年 | 7篇 |
1997年 | 12篇 |
1996年 | 12篇 |
1995年 | 11篇 |
1994年 | 10篇 |
1993年 | 9篇 |
1992年 | 7篇 |
1991年 | 7篇 |
1990年 | 16篇 |
1989年 | 10篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 5篇 |
1985年 | 8篇 |
1984年 | 21篇 |
1983年 | 10篇 |
1982年 | 17篇 |
1981年 | 5篇 |
1980年 | 12篇 |
1979年 | 10篇 |
1978年 | 18篇 |
1977年 | 13篇 |
1976年 | 13篇 |
1975年 | 8篇 |
1974年 | 8篇 |
1973年 | 5篇 |
1968年 | 3篇 |
排序方式: 共有858条查询结果,搜索用时 15 毫秒
81.
Dr. Emmanuelle Rémond Dr. Jean-Alain Fehrentz Laure Liénart Prof. Sébastien Clément Dr. Jean-Louis Banères Dr. Florine Cavelier 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(47):e202201526
Synthesis of fluorescent P-hydroxybinaphtylphosphole-oxide or -sulfide was achieved by trapping a binaphtyl dianion with methyl dichlorophosphite or P-(N,N-diethylamino)dichlorophosphine, followed by oxidation or sulfuration of the P-center. After saponification or acid hydrolysis, the P-hydroxyphospholes were coupled to peptides using the coupling agent BOP, under the conditions required for the synthesis in solution or on a solid support. This new method was illustrated by the labeling of the JMV2959, a potent antagonist of the Growth Hormone Secretagogue Receptor type 1a (GHS−R1a). The labeled conjugates were used to characterize GHSR ligands by competition assays, based on Fluorescence Resonance Energy Transfer (FRET). Such P-hydroxyphosphole-oxide or -sulfide constitute a promising new class of compact fluorophores with large Stokes shift, for labeling biomolecules by grafting through the phosphorus atom. 相似文献
82.
Jean-Louis Luche 《Ultrasonics sonochemistry》1994,1(2):S111-S118
Examples of sonochemical reactions occuring under heterogeneous conditions are discussed with respect to their mechanism. The activation of a metal surface involves complex phenomena, in which parameters of importance seem to be the hardness and the adhesion of the passivating layer. Some considerations are given on the probable link between sonochemistry and tribochemistry. 相似文献
83.
In this paper we define multisections of intervals that yield sharp lower bounds in branch-and-bound type methods for interval global optimization. A so called 'generalized kite', defined for differentiable univariate functions, is built simultaneously with linear boundary forms and suitably chosen centered forms. Proofs for existence and uniqueness of optimal cuts are given. The method described may be used either as an accelerating device or in a global optimization algorithm with an efficient pruning effect. A more general principle for decomposition of boxes is suggested. 相似文献
84.
85.
Sheng Lin Wei Gao Zeru Tian Chao Yang Lihua Lu Jean-Louis Mergny Chung-Hang Leung Dik-Lung Ma 《Chemical science》2015,6(7):4284-4290
A series of luminescent iridium(iii) complexes were synthesised and evaluated for their ability to act as luminescent G-quadruplex-selective probes. The iridium(iii) complex 9 [Ir(pbi)2(5,5-dmbpy)]PF6 (where pbi = 2-phenyl-1H-benzo[d]imidazole; 5,5-dmbpy = 5,5′-dimethyl-2,2′-bipyridine) exhibited high luminescence for G-quadruplex DNA compared to dsDNA and ssDNA, and was employed to construct a G-quadruplex-based assay for protein tyrosine kinase-7 (PTK7) in aqueous solution. PTK7 is an important biomarker for a range of leukemias and solid tumors. In the presence of PTK7, the specific binding of the sgc8 aptamer sequence triggers a structural transition and releases the G-quadruplex-forming sequence. The formation of the nascent G-quadruplex structure is then detected by the G-quadruplex-selective iridium(iii) complex with an enhanced luminescent response. Moreover, the application of the assay for detecting PTK7 in cellular debris and membrane protein extract was demonstrated. To our knowledge, this is the first G-quadruplex-based assay for PTK7. 相似文献
86.
87.
88.
89.
James D. Oliver Adam A. Rosser Christopher M. Fellows Yohann Guillaneuf Jean-Louis Clement Marianne Gaborieau Patrice Castignolles 《Analytica chimica acta》2014
Direct UV detection of carbohydrates in free solution capillary electrophoresis at 270 nm is made possible by a photo-oxidation reaction. Glucose, rhamnose and xylose were shown to have unique UV absorption spectra hypothesizing different UV absorbing intermediates for their respective photo-oxidation. NMR spectroscopy of the photo-oxidation end products proved they consisted of carboxylates and not malondialdehyde as previously theorized and that oxygen thus plays a key role in the photo-oxidation pathway. Adding the photo-initiator Irgacure® 2959 in the background electrolyte increased sensitivity by 40% at an optimum concentration of 1 × 10−4 mM and 1 × 10−8 mM for conventional 50 μm i.d. capillaries and for the corresponding extended light path capillaries, respectively. 相似文献
90.