Preliminary report on detection of papillomaviruses types 6, 11, 16, and 18 in laryngeal benign and malignant lesions

Recently, clinicians have observed an increase in the incidence of laryngeal papilloma coincident with the rising incidence of venereal warts. The lesions occur in young adults of professional singing age. Different types of human papillomavirus (HPV) are presented. Gynecologic exam revealed cervical tumors, involving 18 HPV in benign and malignant lesions. Thirty patients with the following pathologic conditions were studied: 10 papillomas, 10 severe dysplasias, and 10 invasive cancers. All the lesions were located on the free edge of the vocal folds or the anterior commissure involving the epithelium. The results are as follows: 11 patients (33%) had virus infection, of which four had HPV 6 or HPV 11 on laryngeal papilloma, three had HPV 16 or HPV 18 on severe dysplasia, four had HPV 16 or HPV 18 on carcinoma; and 19 (66%) had no virus infection. Gynecologic research in this field is more advanced. However, this preliminary report raises interesting research questions in laryngology.     

Hétérocycles contenant du phosphore. XXXII. Etude de l'action des phosphorhydrazides sur les orthoesters,l'anhydride acétique et l'acide formique

The reaction of phosphodi- or trihydrazides with orthoesters affords mainly 2,3,4,5-tetrahydro-1,2,4,5,3-tetrazaphosphorines and sometimes 4-amino-1,2,4,3-triazaphospholidines. These 1,2,4,5,3-tetrazaphosphorines present a prototropy which explains different pathways of the reaction of these derivatives with formaldehyde or acetone, The structure of all heterocycles which were obtained was established by nmr spectra.     

Dynamic effects of eccentric loads in composite concrete and steel bridge decks made of a pair of main beams

Summary The Authors extend in dynamic range the static theory of non-uniform torsion of thin-walled composite concrete and steel sections.Particularly, the actual range of stresses in bridge decks made by a pair of main composite concrete and steel beams under pulsating loads is investigated.

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Sommario Gli Autori estendono in campo dinamico la teoria statica della torsione non uniforme delle sezioni miste in parete sottile.In particolare viene ricercato lo stato effettivo di sollecitazione in impalcati da ponte costituiti da una coppia di travi principali a sezione mista sotto l'azione di carichi pulsanti.

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The Authors state that they have contributed in equal measure to the drafting of this paper.     

The median procedure in cluster analysis and social choice theory

Classical approachs for fitting and aggregation problems, specially in cluster analysis, social choice theory and paired comparisons methods, consist in the minimization of a remoteness function between relational data and a relational model. The notion of median, with its algebraic, metric, geometrical and statistical aspects, allow a unified treatment of many of base problems. Properties of median procedures are organized according to four directions: stabilities and axiomatic characterizations; Arrow-like properties; combinatorial properties; effective computational possibilities. Finally, interesting mathematical problems, related to the notion of median are surveyed.     

Alcoyl-gluco-alcaloides: nouveaux composes isoles de pauridiantha lyalii brem (rubiacees)

La structure destrans fe´ruloyl-6′ ettrans sinapoyl-6′ lyaloside, isole´s des feuilles dePauridiantha Lyalii, ae´te´de´termine´e par de´gradation chimique et par spectroscopie (Masse, RMN¹H et¹³C). Ces compose´s font partie d'un groupe structural caracte´rise´par un enchai?nement alcaloide-monoterpe`ne-ose-acide (C<sub>6</sub>-C<sub>3</sub>), groupe dont un seul repre´sentant semble avoire´te´isole´jusqu'a`pre´sent. Leur fonction dans le ve´ge´tal est discute´e.     

Mono et Diglycosylbutadiynes

Mono and Diglycosylbutadiynes Cadiot's dissymmetric coupling of bromoethynylsugar derivatives with therminal acetylenes led in good to excellent yields to the expected mono or diglycosylbutadiynes. In the same way, terminal acetylenic sugar derivatives could be coupled with bromoacetylenic compounds. Symmetric coupling of sugars bearing a bromoethynyl group has also been achieved. (UV., CD., IR., ¹H-NMR.) of these compounds are reported and discussed.