Preparation and biological evaluation of radiogallium labeled glucagon for SPECT imaging

In this work, recently prepared ⁶⁷Ga-labeled glucagon (⁶⁷Ga-DTPA-GCG) for imaging studies (radiochemical purity >94%; HPLC, S.A. 296–370 GBq/mM) was used in biological studies. The wild-type rat biodistribution results, 2 h post injection, demonstrated high tissue:muscle ratios for target tissues (liver, kidney, heart, spleen, fat intestine stomach and pancreas), 234, 18.45, 7.12, 1.75, 128.7, 4.9, 6.3 and 1.11, respectively. The tracer binding capacity using freshly prepared rat brain homogenate demonstrated significant specific binding of the tracer to neuronal GCG receptors (⁶⁷Ga-DTPA-GCG/⁶⁷Ga:3 and ⁶⁷Ga-DTPA-GCG/⁶⁷GaDTPA:2.2 at 90 min). SPECT images also demonstrated target specific binding of the tracer at 4 h. The data suggests the tracer is accumulated in GCGR rich tissues 2–4 h post injection, suggesting potentials of the tracer for future imaging studies in glocagonoma models.     

Succinimidinium N-sulfonic acid hydrogen sulfate as an efficient ionic liquid catalyst for the synthesis of 5-arylmethylene-pyrimidine-2,4,6-trione and pyrano[2,3-d]pyrimidinone derivatives

Research on Chemical Intermediates - Succinimidinium N-sulfonic acid hydrogen sulfate ([SuSA-H]HSO4) as a new ionic liquid is prepared and characterized using a variety of techniques, including...     

Development of colorimetric sensor array for discrimination of herbal medicine

Today, traditional systems of medicines (such as herbal distillates) become important resources for providing healthcare benefits. The ability to discriminate among closely similar herbal products is critical to ensure their efficacy. This article proposes a pattern-based recognition approach for the rapid discrimination of herbal distillates using a low-cost and sensitive colorimetric sensor array composed of 25 indicators. The color changes of the sensor exposed to the vapor of the herbal distillates can be monitored easily with an ordinary flatbed scanner. The digital representation of the array response was analyzed with hierarchical clustering analysis (HCA) and principal component analysis (PCA). Using new variable selection strategy, 6 indicators among the 25 employed indicators were selected as discriminant elements of the array. So, a complete discrimination (with 100% accuracy) of 46 herbal distillates was achieved. The proposed sensor represented a better resolution when analytes were placed in an oven at 85 °C for 45 min. This colorimetric sensor array demonstrates excellent potential for quality assurance/control applications of herbal distillates.     

The experimental/numerical investigation of variations in strip speed,water shower pattern and water temperature on high-temperature strip cooling rate in hot strip mill

Journal of Thermal Analysis and Calorimetry - Hot-rolled strips are cooled on the run-out table to achieve the customer-required mechanical properties. Cooling reduces the oxidation, which can...     

A Timoshenko beam reduced order model for shape tracking with a slender mechanism

We consider a flexible bio-inspired slender mechanism, modeled as a Timoshenko beam. It is coupled to the environment by a continuous distribution of compliant elements. We derive a reduced order model by projecting the governing partial differential equations along the linear modal basis of the Timoshenko beam. The coupling with the substrate allows us to formulate the problem in a control framework, and eventually to treat the system as a sensor to reconstruct the profile of the substrate through the deformation of the body. The coupling is modeled in the framework of two parameters elastic foundations. The convergence of the reduced order model with increasing number of basis functions is addressed in a suitable H¹ error norm. A closed loop force control is simulated for shape morphing when the system is coupled with a smooth substrate.     

Magnetic properties of nanostructured MnZn ferrite

Mn_0.5Zn_0.5Fe₂O₄ nanoparticles (10-30 nm) have been prepared via mechanochemical processing, using a mixture of two single-phase ferrites, MnFe₂O₄ and ZnFe₂O₄. SQUID measurements (field-cooled magnetization curves and hysteresis loops) were performed to follow the mechanically induced evolution of the MnFe₂O₄/ZnFe₂O₄ mixture submitted to the high-energy milling process. The resulting single MnZn nanoferrite phase was characterized by SQUID (M-H curve), Faraday balance (M-T curve) and transmission electron microscopy. The magnetic characteristics of the mechanosynthesized material were compared with those of bulk Mn_0.5Zn_0.5Fe₂O₄. It was found that the saturation magnetization of nanostructured Mn_0.5Zn_0.5Fe₂O₄ (87.2 emu/g) is lower than that of the bulk Mn_0.5Zn_0.5Fe₂O₄, but, the Néel temperature of the sample (583 K) is higher than that of the bulk Mn_0.5Zn_0.5Fe₂O₄.     

A novel one-pot synthesis of some new interesting pyrrole derivatives

[reaction: see text] 11-(1H-Pyrrol-1-yl)-11H-indeno[1,2-b]quinoxaline and 3-(1H-pyrrol-1-yl)indolin-2-one derivatives have been synthesized in good yields in a novel, one-pot, and efficient process by condensation of 11H-indeno[1,2-b]quinoxalin-11-one or isatin derivatives with 4-hydroxyproline on solid-support montmorillonite K10 under microwave irradiation.     

Spectrophotometric Study of the Complexation of Some Lanthanide (III) Ions with a Series of 18-Crowns-6 in DMSO Solution Using Murexide as a Metallochromic Indicator

The complexation of La(III), Ce(III), Pr(III) and Er(III) with 18-crown-6(18C6), dibenzo-18-crown-6 (DB18C6), dicyclohexano-18-crown-6 (DCY18C6) anddibenzopyridino-18-crown-6 (DBPY18C6) has been studied in dimethylsulfoxide(DMSO) by means of a competitive spectrophotometric method using murexide asa metal ion indicator. The formation constants of the 1 : 1 complexeswere found tovary in the order La(III) > Ce(III) > Pr(III) > Er(III). It was foundthat the structure influences the formation and stability of the resultingcomplexes. The effects ofvarious parameters on complexation are discussed. The order of the stabilityconstants of each lanthanide ion with these macrocycles are18C6 > DC18C6 > DB18C6 > DBPY18C6.