Efficient One‐Pot Solvent‐Free Synthesis of 1H‐Pyrazolo[1,2‐b]phthalazine‐5,10‐diones Catalyzed by Sulfonic Acid Functionalized Nanoporous Silica (SBA‐Pr‐SO3H)

A green protocol has been developed for the synthesis of 1H‐pyrazolo[1,2‐b]phthalazine‐5,10‐diones by one‐pot cyclocondensation reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate using sulfonic acid functionalized SBA‐15 (SBA‐Pr‐SO₃H) as a heterogeneous solid acid catalyst under solvent‐free conditions.     

Three‐component One‐pot Synthetic Route to Functionalized N‐Phenyl‐ and N,N‐(1,4‐phenylene)‐2‐alkylimino‐2,3‐dihydrothiazoles under Mild,Solvent‐ and Catalyst‐free Conditions

A simple and efficient one‐pot synthesis of alkyl‐2‐(alkylimino)‐4‐methyl‐3‐phenyl‐2,3‐dihydrothiazole‐5‐carboxylate and dialkyl 3,3′‐(1,4‐phenylene)‐bis‐[2‐(alkylimino)‐4‐methyl‐2,3‐dihydrothiazole‐5‐carboxylate] derivatives from the reaction of phenylisothiocyanate (and also 1,4‐phenylene diisothiocyanate) and primary alkylamines in the presence of 2‐chloro‐1,3‐dicarbonyl compounds is described. This new protocol has several advantages such as lack of necessity of the catalyst and solvent, good yields,mild conditions and short times for reaction.     

Understanding lipid recognition by protein-mimicking cyclic peptides

This paper describes our investigation of the structural determinants of a designed cyclic peptide (cLac, cyclic peptide mimicking lactadherin) (Zheng, H.; Wang, F.; Wang, Q.; Gao, J. J. Am. Chem. Soc.2011, 133, 15280–15283) for phosphatidylserine (PS) recognition. A highly efficient strategy that takes advantage of the native chemical ligation (NCL) chemistry has been developed for the synthesis and labeling of cyclic peptides in general. Ala scanning of the cLac peptide revealed a sophisticated model for PS binding, in which the peptide scaffold assembles multiple polar residues to balance the desolvation and electrostatic interactions (salt bridge and hydrogen bonding) to achieve lipid selectivity. The results suggest that cLac effectively mimics the membrane binding mechanism of the parent protein lactadherin.     

Modified Glassy Carbon Rotating Disk Electrode for Determination of Heterogeneous Reaction Rate Constant of H2O2 Decomposition

Modified glassy carbon RDE method is introduced in this work for the determination of heterogeneous reaction rate constant of H₂O₂ decomposition. This method is based on the analysis of RDE voltammograms of H₂O₂ reduction on a glassy carbon electrode covered with a catalyst layer. As a case study, the rate constant of H₂O₂ decomposition on nitrogen doped graphene is determined by using both glassy carbon and gold RDE methods. A good agreement is observed between the results of these two methods indicating the reliability of the glassy carbon method. Moreover, advantages and limitations of the glassy carbon method are discussed.     

Synthesis of pyrazolopyridines catalyzed by nano-CdZr4(PO4)6 as a reusable catalyst

Research on Chemical Intermediates - A simple and efficient method for the preparation of pyrazolopyridines by a multicomponent reaction of ethyl acetoacetate, an aldehyde, hydrazine and ammonium...     

用于光电化学氧化氯酸盐的钒酸铋光电阳极的合成与表征

采用便捷的涉及电沉积和退火过程的两步法在F掺杂的氧化锡基体上制备了高品质的多晶钒酸铋(BiVO4)薄膜,并运用扫描电镜、透射电镜、X射线衍射(XRD)、傅里叶变换红外光谱、紫外-可见光吸收光谱和拉曼光谱表征了所制薄膜的形貌和结构特征.XRD和光学分析结果表明,BiVO4薄膜为纯相的单斜白钨矿晶相结构.将该薄膜通过电化学(EC),光化学(PC)和光电化学(PEC)过程用于水溶液中氯酸离子的多相氧化反应中.采用紫外-可见吸附光谱仪监测氯酸盐浓度的降低.结果发现,在光的照射下采用PEC法时,BiVO4可有效催化氯酸盐的氧化.氯酸盐氧化反应级数为1级,PEC过程的反应速率常数明显高于EC和PC过程的.同时,提出了基于形成了高氯酸离子的催化氧化氯酸盐的反应机理.     

Efficient Synthesis of Highly Functionalized Thiazolidine-4-ones Under Solvent-Free Conditions

Summary. 4-Phenylthiosemicarbazide reacts smoothly with dimethyl acetylenedicarboxylate in the presence of aldehydes or ketones under solvent free conditions to produce highly functionalized thiazolidine-4-ones.     

The correlations between processing parameters and magnetic properties of an iron–resin soft magnetic composite

In this study, internal microstrain of an iron–resin composite produced by powder metallurgy has been calculated using the Williamson–Hall method. The effects of microstrain evolution during different processing conditions on magnetic properties such as coercive force and hysteresis loss have been investigated. The results show that there are regular and similar changes of coercivity and hysteresis loss. Both of these properties are directly dependant on the pinning effect of the internal microstrain against the movement of magnetic domain walls during magnetization process.