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排序方式: 共有98条查询结果,搜索用时 15 毫秒
41.
42.
Henrieta Stankovi
ov Anton Gplovský Margita Lcov Jarmila Chovancov Agnieszka Puchala 《Journal of heterocyclic chemistry》2006,43(4):843-848
Reaction of 6‐methyl‐4‐oxo‐4H‐[1]‐benzopyran‐3‐carboxaldehyde 1 with 5‐amino‐3‐methyl‐1‐phenylpyrazole 2 in alcoholic reaction media in the presence of 4‐toluenesulfonic acid as catalyst afforded 5‐(2‐hydroxy‐5‐methylbenzoyl)‐3‐methyl‐1‐phenyl‐1H‐pyrazolo[3,4‐b]pyridine 3 and 2‐methoxy‐6‐methyl‐3‐(3‐methyl‐1‐phenylpyrazol‐5‐ylaminomethylene)chroman‐4‐one 7 . We explain the mechanism of formation of both products on the basis of kinetic study of individual reaction steps. 相似文献
43.
Vinsova J Imramovsky A Buchta V Ceckova M Dolezal M Staud F Jampilek J Kaustova J 《Molecules (Basel, Switzerland)》2007,12(1):1-12
A new series of salicylanilide acetates was synthesized and evaluated for their in vitro antifungal and antituberculotic activity. Some of the evaluated compounds possessed comparable or better antifungal activity than a fluconazole standard. All these compounds exhibited very good potential and their in vitro activity against drug resistant and sensitive clinical isolates of Mycobacteria were found to be equivalent or better than a standard of isoniazide, a well-known first-line drug for tuberculosis treatment. 相似文献
44.
A Imramovsky S Stepankova J Vanco K Pauk J Monreal-Ferriz J Vinsova J Jampilek 《Molecules (Basel, Switzerland)》2012,17(9):10142-10158
A series of twenty-five novel salicylanilide N-alkylcarbamates were investigated as potential acetylcholinesterase inhibitors. The compounds were tested for their ability to inhibit acetylcholinesterase (AChE) from electric eel (Electrophorus electricus L.). Experimental lipophilicity was determined, and the structure-activity relationships are discussed. The mode of binding in the active site of AChE was investigated by molecular docking. All the discussed compounds expressed significantly higher AChE inhibitory activity than rivastigmine and slightly lower than galanthamine. Disubstitution by chlorine in C'(3,4) of the aniline ring and the optimal length of hexyl-undecyl alkyl chains in the carbamate moiety provided the most active AChE inhibitors. Monochlorination in C'(4) exhibited slightly more effective AChE inhibitors than in C'(3). Generally it can be stated that compounds with higher lipophilicity showed higher inhibition, and the activity of the compounds is strongly dependent on the length of the N-alkyl chain. 相似文献
45.
46.
Sylvie Skalickova Ondrej Zitka Lukas Nejdl Sona Krizkova Jiri Sochor Libor Janu Marketa Ryvolova David Hynek Jarmila Zidkova Vaclav Zidek Vojtech Adam Rene Kizek 《Chromatographia》2013,76(7-8):345-353
Quantum dots (QDs) belong to a new class of fluorescent agent for biochemical, medicinal or other purposes. However, QDs based on cadmium or other metals can be risky for an organism. As one of the mechanism how to detoxify cadmium-based QDs expression of metallothioneins (MT) can be considered. Due to high affinity of metallothionein to cadmium(II) ions, we attempted to develop an approach for studying of possible interaction with QDs. We prepared QDs with CdTe core and studied the interaction with MT, which we isolated from livers of Cd-administered rabbits. To study the interaction, we used the mixture of both components MT (3.6 μM): CdTe QDs (0, 0.34, 0.68, 1.02, 1.36, 1.7, 2.04 and 2.47 μM). The mixtures were studied by spectrophotometry within the range from 200 to 750 nm with detected maxima at 260 and 505 nm. Same mixtures were also analysed by differential pulse voltammetry Brdicka reaction, which supported data from spectrophotometry. Subsequently, we used fast protein liquid chromatography for purification of protein–quantum dot conjugates. We obtained the different chromatograms for (1) Apo MT, (2) CdTe QDs and (3) MT–QD complex. We also collected the fractions and subsequently analysed them on the content of Cd and MT, which confirmed the formation of CdTe QDs–MT complex. 相似文献
47.
Investigator® Argus X‐12 study on the population of Czech Republic: Comparison of linked and unlinked X‐STRs for kinship analysis 下载免费PDF全文
DNA samples of 523 unrelated anonymized individuals (307 males and 216 females) born and living in the Czech Republic were genotyped using Investigator® Argus X‐12 system in the following loci localized in four linkage groups: DXS10148, DXS10135, DXS8378, DXS7132, DXS10079, DXS10074, DXS10103, HPRTB, DXS10101, DXS10146, DXS10134, DXS742. Haplotype frequencies were calculated for each LG (Linkage Group). The frequency of most common haplotype was 0.016, 0.036, 0.042, and 0.023 for LG1, LG2, LG3, and LG4, respectively. The combined power of discrimination was more than 0.999999999 both for female and male samples. The mean exclusion chance was 0.99999999 (trios) and 0.999999 (duos). Informativity and suitability of Investigator® Argus X‐12 for kinship determination was assessed by computing in several female–female duos using LR (Likelihood Ratio) determination for autosomal STR (PowerPlex ESI‐17), linked (Investigator® Argus X‐12 system), and unlinked (X‐STR Decaplex) X‐STR kits. Investigator® Argus X‐12 proved to be very useful for sibship determination, since its LR values were relatively similar to LR for autosomal STR kit. This work presents the first population data for Investigator® Argus X‐12 system in the Czech Republic. 相似文献
48.
Jarmila Omet��kov�� Silvia Dulansk�� L��ubom��r M��tel Boris Remenec 《Journal of Radioanalytical and Nuclear Chemistry》2011,290(2):319-323
We studied the use of an extraction chromatography for determination of 90Sr in contaminated water samples. The aim of our work was to compare selected products from the point of view of the strontium chemical yields and analysis time. Three commercial products, 3M Empore? Strontium Rad Disk, AnaLig® Sr-01 gel, Sr®Resin, and two classical methods, liquid?Cliquid extraction with tributhylphosphate and carbonate co-precipitation, were tested for the separation of 90Sr. The water sample from nuclear power plant A1 Jaslovske Bohunice was used for radiochemical analysis of 90Sr volume activity. Samples were traced with 85Sr to monitor strontium chemical recovery and counted either by Cerenkov counting on TRI CARB 2900 TR liquid scintillation counter or low level alpha?Cbeta proportional counter. 相似文献
49.
Dana Gabrovská Jarmila Ouhrabková Jana Rysová Ivana Laknerová Vlasta Fiedlerová Marie Holasová 《高压研究》2013,33(1):103-113
The aim of this work was to find sensory suitable combinations of not commonly used vegetables, that is, cabbage, celeriac and parsnip, into mixed fruit–vegetable juices, two-species vegetable juices and vegetable juices with whey. These juices might have the potential to offer consumers new, interesting, tasty and nutritional products. Another interesting variation could be preparation of vegetable juices in combination with sweet whey. Nutritional and sensory evaluations were carried out using juices prepared in the laboratory. The total phenolic content, in addition to ascorbic acid and antioxidant activity, was determined. The developed juices with high nutritional value should increase very low fruit and vegetable consumption in the Czech population. The prepared juices were high pressure pasteurized (410 MPa). This technique retains the desired levels of important nutritional substances, while being destructive to live microbial cell structure. The germination of spores is suppressed by low pH value. 相似文献
50.
Radek Zeipl Jarmila Walachová Martin Pavelka Miroslav Jelínek Václav Studnička Tomáš Kocourek 《Applied Physics A: Materials Science & Processing》2008,93(3):663-667
Room temperature conductivity and the Seebeck coefficient of thin layers prepared by laser ablation from Bi2Te3 target were explored. The power factor was calculated for samples prepared at substrate temperature of 360°C with the density
of the laser beam 5 J cm−2 and at substrate temperature of 410°C with the density of the laser beam 2 J cm−2 during the deposition. Oscillations of the conductivity and the power factor with the layer thickness were observed at room
temperature. The oscillations of conductivity were also verified at the temperature of 77 K. The period of oscillations depends
on the preparation conditions. This behavior has been theoretically explained by the quantum size effect in the layers containing
different phases and in addition, it was demonstrated by the X-ray Diffraction measurement.
The behavior of the power factor of the layers is compared to the behavior of the figure of merit of the layers published
earlier. 相似文献