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61.
Jean Claude Didelot Tomani Olivier Bonnet Alain Nyirimigabo William Deschamps Alembert Tiabou Tchinda Olivia Jansen Allison Ledoux Marie Jeanne Mukazayire Luc Vanhamme Michel Frdrich Raymond Muganga Jacob Souopgui 《Molecules (Basel, Switzerland)》2021,26(9)
Malaria remains one of the leading causes of death in sub-Saharan Africa, ranked in the top three infectious diseases in the world. Plants of the Eriosema genus have been reported to be used for the treatment of this disease, but scientific evidence is still missing for some of them. In the present study, the in vitro antiplasmodial activity of the crude extract and compounds from Eriosema montanum Baker f. roots were tested against the 3D7 strain of Plasmodium falciparum and revealed using the SYBR Green, a DNA intercalating compound. The cytotoxicity effect of the compounds on a human cancer cell line (THP-1) was assessed to determine their selectivity index. It was found that the crude extract of the plant displayed a significant antiplasmodial activity with an IC50 (µg/mL) = 17.68 ± 4.030 and a cytotoxic activity with a CC50 (µg/mL) = 101.5 ± 12.6, corresponding to a selective antiplasmodial activity of 5.7. Bioactivity-guided isolation of the major compounds of the roots’ crude extract afforded seven compounds, including genistein, genistin and eucomic acid. Under our experimental conditions, using Artemisinin as a positive control, eucomic acid showed the best inhibitory activity against the P. falciparum 3D7, a well-known chloroquine-sensitive strain. The present results provide a referential basis to support the traditional use of Eriosema species in the treatment of malaria. 相似文献
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Parks Conor D. Gaieb Zied Chiu Michael Yang Huanwang Shao Chenghua Walters W. Patrick Jansen Johanna M. McGaughey Georgia Lewis Richard A. Bembenek Scott D. Ameriks Michael K. Mirzadegan Tara Burley Stephen K. Amaro Rommie E. Gilson Michael K. 《Journal of computer-aided molecular design》2020,34(2):99-119
Journal of Computer-Aided Molecular Design - The Drug Design Data Resource (D3R) aims to identify best practice methods for computer aided drug design through blinded ligand pose prediction and... 相似文献
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Dr. Christianus M. A. Leenders Gijs Jansen Martijn M. M. Frissen René P. M. Lafleur Dr. Ilja K. Voets Dr. Anja R. A. Palmans Prof. Dr. E. W. Meijer 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(13):4608-4615
We introduce monosaccharides as versatile water‐soluble units to compatibilise supramolecular polymers based on the benzene‐1,3,5‐tricarboxamide (BTA) moiety with water. A library of monosaccharide‐based BTAs is evaluated, varying the length of the alkyl chain (hexyl, octyl, decyl and dodecyl) separating the BTA and saccharide units, as well as the saccharide units (α‐glucose, β‐glucose, α‐mannose and α‐galactose). In all cases, the monosaccharides impart excellent water compatibility. The length of the alkyl chain is the determining factor to obtain either long, one‐dimensional supramolecular polymers (dodecyl spacer), small aggregates (decyl spacer) or molecularly dissolved (octyl and hexyl) BTAs in water. For the BTAs comprising a dodecyl spacer, our results suggest that a cooperative self‐assembly process is operative and that the introduction of different monosaccharides does not significantly change the self‐ assembly behaviour. Finally, we investigate the potential of post‐assembly functionalisation of the formed supramolecular polymers by taking advantage of dynamic covalent bond formation between the monosaccharides and benzoxaboroles. We observe that the supramolecular polymers readily react with a fluorescent benzoxaborole derivative permitting imaging of these dynamic complexes by confocal fluorescence microscopy. 相似文献
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The authors propose a method for the extraction of material parameter and thickness information from sub-100-μm thin samples using non-differential transmission terahertz time domain spectroscopy. The approach relies on an additional Fourier transform of the frequency dependent material parameters to a quasi space regime. In this quasi space, periodic Fabry-Perot oscillations from the frequency domain, which originate from multiple reflections inside the sample, correspond to discrete peaks. By iterative minimization of these peaks, the highly precise thickness information along with the refractive index and absorption coefficient of the sample can be determined. Experimental verification of the approach is also provided. 相似文献
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Reduction of C70 with alkaline earth and rare earth metals dissolved in liquid ammonia results in metal fulleride solvates AC70.nNH3 (A = Ca, Sr, Ba, Eu, Yb) containing linear polymeric, anionic chains infinity 1 [C70(2-)]. The compounds were characterised by means of Raman spectroscopy and single-crystal structure determination. The accurate crystal structure of [Sr(NH3)8]C70.3NH3, determined with atomic resolution, allowed for a comparison with results of quantum chemical calculations. The nature of the C-C bonds in the fulleride is analysed in detail leading to a model explaining the unexpected polymerisation of C70(2-). 相似文献
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The polarized electronic absorption spectra of a blue vanadium-doped zircon single crystal, grown by the flux method, has been studied by quantum chemical (CI) calculations in order to determine the position of the V4+ dopant in the zircon host structure. Particularly, the excitation energies and polarizations of V4+ occupying alternate positions, either the zirconium or silicon position or the interstitial site 16g, have been considered. It is concluded that the observed electronic absorption spectra and the color of zirconblue can only be explained if the V4+ chromophore is placed on the respective interstitial position. 相似文献