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201.
Urathamakul T Waller DJ Beck JL Aldrich-Wright JR Ralph SF 《Inorganic chemistry》2008,47(15):6621-6632
Electrospray ionization mass spectrometry (ESI-MS) was used to study the binding interactions of two series of ruthenium complexes, [Ru(phen) 2L] (2+) and [RuL' 2(dpqC)] (2+), to a double stranded DNA hexadecamer, and derive orders of relative binding affinity. These were shown to be in good agreement with orders of relative binding affinity derived from absorption and circular dichroism (CD) spectroscopic examination of the same systems and from DNA melting curves. However, the extent of luminescence enhancement caused by the addition of DNA to solutions of the ruthenium complexes showed little correlation with orders of binding affinity derived from ESI-MS or any of the other techniques. Overall the results provide support for the validity of using ESI-MS to investigate non-covalent interactions between metal complexes and DNA. 相似文献
202.
Wheate NJ Kumar PG Torres AM Aldrich-Wright JR Price WS 《The journal of physical chemistry. B》2008,112(8):2311-2314
The self-diffusion of cucurbit[7]uril (CB[7]) and its host-guest complexes in D2O has been examined using pulsed gradient spin-echo nuclear magnetic resonance spectroscopy. CB[7] diffuses freely at a concentration of 2 mM with a diffusion coefficient (D) of 3.07 x 10(-10) m(2) s(-1). At saturation (3.7 mM), CB[7] diffuses more slowly (D = 2.82 x 10(-10) m(2) s(-1)) indicating that it partially self-associates. At concentrations between 2 and 200 mM, CsCl has no effect on the diffusion coefficient of CB[7] (1 mM). Conversely, CB[7] (2 mM) significantly affects the diffusion of 133Cs+ (1 mM), decreasing its diffusion coefficient from 1.86 to 0.83 x 10(-9) m(2) s(-1). Similar changes in the rate of diffusion of other alkali earth metal cations are observed upon the addition of CB[7]. The diffusion coefficient of 23Na+ changes from 1.26 to 0.90 x 10(-9) m(2) s(-1) and 7Li+ changes from 3.40 to 3.07 x 10(-9) m(2) s(-1). In most cases, encapsulation of a variety of inorganic and organic guests within CB[7] decreases their rates of diffusion in D2O. For instance, the diffusion coefficient of the dinuclear platinum complex trans-[[PtCl(NH3)2}2mu-dpzm](2+) (where dpzm is 4,4'-dipyrazolylmethane) decreases from 4.88 to 2.95 x 10(-10) m(2) s(-1) upon encapsulation with an equimolar concentration of CB[7]. 相似文献
203.
Yanagawa F Ishii Y Onuki Y Morishita M Takayama K 《Colloids and surfaces. B, Biointerfaces》2008,63(1):146-152
Sustained release diltiazem hydrochloride (DIL) formulation is widely used over 110 countries worldwide, and is among the drugs recommended as a first-line therapy in the major guidelines for the management of hypertension. In search for a most suitable controlled release formulation of DIL, we investigated poly (2-hydroxyethyl methacrylate) matrix (pHEMA matrix) synthesized by photopolymerization. Factors affecting the release rate of DIL from pHEMA matrices were investigated, focusing on the internal structure of the matrices. The effects of the porosity (epsilon), the fractal dimensions (Df) and the microscopic viscosity (eta matrix) of the matrices on the release rate of DIL were investigated on the basis of the linear least square equation as well as the Higuchi's equation. A relation between the actual value and predicted value based on the linear least square equation exhibited a fairly good linearity (r=0.979). Furthermore, the release rate of DIL was represented based on the Higuchi's equation including the values of epsilon, Df and eta matrix. It is likely that the release rate of DIL from pHEMA matrices is mainly controlled by epsilon and Df, but eta matrix was less effective. 相似文献
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206.
Volodymyr Svitlyk Yan Yin Janice Cheung Yurij Mozharivskyj 《Journal of solid state chemistry》2009,182(9):2543-2548
GdFe7.7Si1.3 was synthesized by arc-melting with subsequent annealing at 1000 °C for 4 weeks. The basic structure of GdFe7.7Si1.3 is similar to that of CaCu5 but features random substitution of Gd atoms by Fe2 dumbbells along the z-axis. This random Gd/Fe2 distribution makes the GdFe7.7Si1.3 structure an intermediate between the CaCu5 (no dumbbells) and Th2(Ni/Zn)17 (full ordering of dumbbells) structures. Single crystal X-ray diffraction also points at the formation of a superstructure of a lower symmetry and diffuse scattering between the superstructure spots. GdFe7.7Si1.3 orders ferromagnetically at 640 K and exhibits a soft magnetic behavior. 相似文献
207.
Angelico D. Aputen Maria George Elias Jayne Gilbert Jennette A. Sakoff Christopher P. Gordon Kieran F. Scott Janice R. Aldrich-Wright 《Molecules (Basel, Switzerland)》2022,27(20)
A new series of cytotoxic platinum(IV) complexes (1–8) incorporating halogenated phenylacetic acid derivatives (4-chlorophenylacetic acid, 4-fluorophenylacetic acid, 4-bromophenylacetic acid and 4-iodophenylacetic acid) were synthesised and characterised using spectroscopic and spectrometric techniques. Complexes 1–8 were assessed on a panel of cell lines including HT29 colon, U87 glioblastoma, MCF-7 breast, A2780 ovarian, H460 lung, A431 skin, Du145 prostate, BE2-C neuroblastoma, SJ-G2 glioblastoma, MIA pancreas, the ADDP-resistant ovarian variant, and the non-tumour-derived MCF10A breast line. The in vitro cytotoxicity results confirmed the superior biological activity of the studied complexes, especially those containing 4-fluorophenylacetic acid and 4-bromophenylacetic acid ligands, namely 4 and 6, eliciting an average GI50 value of 20 nM over the range of cell lines tested. In the Du145 prostate cell line, 4 exhibited the highest degree of potency amongst the derivatives, displaying a GI50 value of 0.7 nM, which makes it 1700-fold more potent than cisplatin (1200 nM) and nearly 7-fold more potent than our lead complex, 56MESS (4.6 nM) in this cell line. Notably, in the ADDP-resistant ovarian variant cell line, 4 (6 nM) was found to be almost 4700-fold more potent than cisplatin. Reduction reaction experiments were also undertaken, along with studies aimed at determining the complexes’ solubility, stability, lipophilicity, and reactive oxygen species production. 相似文献
208.
Daniel M. Day Thomas J. Farmer Joe Granelli Janice H. Lofthouse Julie Lynch Con R. McElroy James Sherwood Seishi Shimizu James H. Clark 《Molecules (Basel, Switzerland)》2022,27(23)
Green chemistry places an emphasis on safer chemicals, waste reduction, and efficiency. Processes should be optimized with green chemistry at the forefront of decision making, embedded into research at the earliest stage. To assist in this endeavor, we present a spreadsheet that can be used to interpret reaction kinetics via Variable Time Normalization Analysis (VTNA), understand solvent effects with linear solvation energy relationships (LSER), and calculate solvent greenness. With this information, new reaction conditions can be explored in silico, calculating product conversions and green chemistry metrics prior to experiments. The application of this tool was validated with literature case studies. Reaction performance was predicted and then confirmed experimentally for examples of aza-Michael addition, Michael addition, and an amidation. The combined analytical package presented herein permits a thorough examination of chemical reactions, so that the variables that control reaction chemistry can be understood, optimized, and made greener for research and education purposes. 相似文献
209.
Transition metal trichalcogenides TaSe3, TaS3, NbSe3 and NbS3 were prepared under the reaction conditions of 2 GPa, 700°C, 30 min. NbSe3 is exactly the same as that obtained in the usual sealed-tube method. The other products are modifications of each usual phase. They have crystal structures very similar to that of NbSe3. The lattice parameters are a = 10.02Å, b = 3.48 Å, c = 15.56 Å, β = 109.6° for TaSe3, a = 9.52 Å, b = 3.35 Å, c = 14.92 Å, β = 110.0° for TaS3, and a = 9.68 Å, b = 3.37 Å, c = 14.83 Å, β = 109.9° for NbS3. In spite of the similarity in their crystal structures, these high-pressure phases show a variety of electrical transport properties. TaSe3 is a superconductor having Tc at 1.9 K. TaS3 is a semiconductor with two transitions at 200 and 250 K. NbS3 is a semiconductor with Ea = 180 MeV. 相似文献
210.
Denilson de Jesus Assis Líllian Vasconcelos Brandão Larissa Alves de Sousa Costa Tamiris Vilas Boas Figueiredo Luciane Santos Sousa Francine Ferreira Padilha Janice Izabel Druzian 《Applied biochemistry and biotechnology》2014,172(5):2769-2785
The effects of aeration and agitation on the properties and production of xanthan gum from crude glycerin biodiesel (CGB) by Xanthomonas campestris mangiferaeindicae 2103 were investigated and optimized using a response surface methodology. The xanthan gum was produced from CGB in a bioreactor at 28 °C for 120 h. Optimization procedures indicated that 0.97 vvm at 497.76 rpm resulted in a xanthan gum production of 5.59 g L?1 and 1.05 vvm at 484.75 rpm maximized the biomass to 3.26 g L?1. Moreover, the combination of 1.05 vvm at 499.40 rpm maximized the viscosity of xanthan at 0.5 % (m/v), 25 °C, and 25 s?1 (255.40 mPa s). The other responses did not generate predictive models. Low agitation contributed to the increase of xanthan gum production, biomass, viscosity, molecular mass, and the pyruvic acid concentration. Increases in the agitation contributed to the formation of xanthan gum with high mannose concentration. Decreases in the aeration contributed to the xanthan gum production and the formation of biopolymer with high mannose and glucose concentrations. Increases in aeration contributed to increased biomass, viscosity, and formation of xanthan gum with greater resistance to thermal degradation. Overall, aeration and agitation of CGB fermentation significantly influenced the production of xanthan gum and its properties. 相似文献