全文获取类型
收费全文 | 2715篇 |
免费 | 162篇 |
国内免费 | 18篇 |
专业分类
化学 | 2068篇 |
晶体学 | 47篇 |
力学 | 83篇 |
数学 | 174篇 |
物理学 | 523篇 |
出版年
2024年 | 4篇 |
2023年 | 22篇 |
2022年 | 54篇 |
2021年 | 64篇 |
2020年 | 63篇 |
2019年 | 69篇 |
2018年 | 45篇 |
2017年 | 46篇 |
2016年 | 101篇 |
2015年 | 97篇 |
2014年 | 131篇 |
2013年 | 201篇 |
2012年 | 234篇 |
2011年 | 257篇 |
2010年 | 150篇 |
2009年 | 130篇 |
2008年 | 191篇 |
2007年 | 159篇 |
2006年 | 141篇 |
2005年 | 118篇 |
2004年 | 126篇 |
2003年 | 102篇 |
2002年 | 85篇 |
2001年 | 61篇 |
2000年 | 55篇 |
1999年 | 22篇 |
1998年 | 14篇 |
1997年 | 10篇 |
1996年 | 32篇 |
1995年 | 11篇 |
1994年 | 13篇 |
1993年 | 14篇 |
1992年 | 15篇 |
1991年 | 7篇 |
1990年 | 9篇 |
1989年 | 4篇 |
1988年 | 5篇 |
1987年 | 5篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1983年 | 1篇 |
1982年 | 4篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1978年 | 1篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1972年 | 1篇 |
1930年 | 2篇 |
排序方式: 共有2895条查询结果,搜索用时 46 毫秒
41.
42.
43.
Silver ions dissolved in a polymer matrix are additionally coordinated by carbonyl oxygens of asparagines and their counter anions interact with cationic sites, resulting in the enhanced activity of the silver ion as an olefin carrier for facilitated olefin transport. 相似文献
44.
Jang MJ Lee MJ Park HY Bae YS Min DS Ryu SH Kwak JY 《Experimental & molecular medicine》2004,36(2):172-178
Agents that elevate cellular cAMP are known to inhibit the activation of phospholipase D (PLD). We investigated whether PLD can be phosphorylated by cAMP-dependent protein kinase (PKA) and PKA-mediated phosphorylation affects the interaction between PLD and RhoA, a membrane regulator of PLD. PLD1, but not PLD2 was found to be phosphorylated in vivo by the treatment of dibutyryl cAMP (dbcAMP) and in vitro by PKA. PKA inhibitor (KT5720) abolished the dbcAMP-induced phosphorylation of PLD1, but dibutyryl cGMP (dbcGMP) failed to phosphorylate PLD1. The association between PLD1 and Val14RhoA in an immunoprecipitation assay was abolished by both dbcAMP and dbcGMP. Moreover, RhoA but not PLD1 was dissociated from the membrane to the cytosolic fraction in dbcAMP-treated cells. These results suggest that both PLD1 and RhoA are phosphorylated by PKA and the interaction between PLD1 and RhoA is inhibited by the phosphorylation of RhoA rather than by the phosphorylation of PLD1. 相似文献
45.
[reaction: see text]. Highly enantioenriched quaternary centers are obtained by the reaction of chiral lithiated intermediates complexed to (-)-sparteine with tetrasubstituted, alpha,alpha-dinitrile activated olefins. Lithiated N-Boc-N-Aryl benzylamine furnishes products with drs from 78:22 to 95:5, with ers exceeding 94:6. Lithiated N-Boc-N-Aryl allylamine reactants provide enecarbamate products with drs from 55:45 to 99:1, with ers ranging from 87:13 to 97:3. 相似文献
46.
Cell lysis was demonstrated on a microfluidic CD (Compact Disc) platform. In this purely mechanical lysis method, spherical particles (beads) in a lysis chamber microfabricated in a CD, cause disruption of mammalian (CHO-K1), bacterial (Escherichia coli), and yeast (Saccharomyces cerevisiae) cells. Interactions between beads and cells are generated in the rimming flow established inside a partially filled annular chamber in the CD rotating around a horizontal axis. To maximize bead-cell interactions in the lysis chamber, the CD was spun forward and backwards around this axis, using high acceleration for 5 to 7 min. Investigation on inter-particle forces (friction and collision) identified the following parameters; bead density, angular velocity, acceleration rate, and solid volume fraction as having the most significant contribution to cell lysis. Cell disruption efficiency was verified either through direct microscopic viewing or measurement of the DNA concentration after cell lysing. Lysis efficiency relative to a conventional lysis protocol was approximately 65%. In the long term, this work is geared towards CD based sample-to-answer nucleic acid analysis which will include cell lysis, DNA purification, DNA amplification, and DNA hybridization detection. 相似文献
47.
Yoon MS Ahn KH Cheung RW Sohn H Link JR Cunin F Sailor MJ 《Chemical communications (Cambridge, England)》2003,(6):680-681
Free-standing porous Si multilayer dielectric mirrors, prepared by electrochemical etching of crystalline Si, are treated with a ruthenium ring-opening metathesis polymerization (ROMP) catalyst followed by norbornene to produce flexible, stable composite materials in which poly(norbornene) is covalently attached to the porous Si matrix. 相似文献
48.
Peng CY Nam WJ Fonash SJ Gu B Sen A Strawhecker K Natarajan S Foley HC Kim SH 《Journal of the American Chemical Society》2003,125(31):9298-9299
We describe the use of hard etching methods to create nanodimensional channels and their use as templates for the formation of polymer filament arrays with precise dimensional and orientational control in a single integrated step. The procedure is general as illustrated by the radical, coordination, and photochemical polymerizations that were performed in these nanochannels. The nanochannel templates (20 nm high, 20-200 nm wide, and 100 mum long) were fabricated by the combined use of electron-beam lithography and a sacrificial metal line etching technique. Radical polymerization of acrylates, metal-catalyzed polymerization of norbornene, and photochemical polymerization of 1,4-diiodothiophene were carried out in these nanochannels. The polymers grown follow the dimensions and orientation of the channels, and the polymer filaments can be released without breaking. The approach opens up the possibility of just-in-place manufacturing and processing of patterns and devices from nanostructured polymers using well-established polymer chemistry. 相似文献
49.
The excited-state proton-transfer dynamics of 7-azaindole occurring in the water nanopools of reverse micelles has been investigated by measuring time-resolved fluorescence spectra and kinetics, as well as static absorption and emission spectra, with varying water content and isotope. 7-Azaindole molecules are found to exist in the bound-water regions of reverse micelles. The rate constant and the kinetic isotope effect of proton transfer are smaller than those in bulk water although both increase with the size of the water nanopool. The retardation of proton transfer in the bound regions is attributed to the increased free energy of prerequisite solvation to form a cyclically H-bonded 1:1 7-azaindole/water complex. 相似文献
50.
Chun Hag Jang Jong Ryul Kim Taikyue Ree 《Journal of polymer science. Part A, Polymer chemistry》1986,24(12):3171-3176
The non-Newtonian intrinsic viscosities [η] of poly(γ-methyl L-glutamate) were measured in the helix–coil transition region under various conditions in this work. The helix content fH, which represents the degree of conformational transition, was obtained by using a polarimeter. Our experimental results show that the non-Newtonian behavior of the polypeptide is markedly affected by its conformation; i.e., the non-Newtonian effect becomes larger as fH increases. The effect of external pressure ΔP on [η] was studied carefully; [η] increases with fH when ΔP < 1.5 psi, but it decreases when ΔP > 1.5 psi and fH > 0.8. The reason for this result is considered in the text. 相似文献