Preclinical evaluation of 188 Re-HYNIC-PSMA as a novel therapeutic agent

Journal of Radioanalytical and Nuclear Chemistry - In this study, optimized preparation, quality control, cell assessments and biostribution of 188Re-HYNIC-PSMA in normal rats and tumor bearing...     

Phytochemical Profiling of Lavandula coronopifolia Poir. Aerial Parts Extract and Its Larvicidal,Antibacterial, and Antibiofilm Activity Against Pseudomonas aeruginosa

Infections associated with the emergence of multidrug resistance and mosquito-borne diseases have resulted in serious crises associated with high mortality and left behind a huge socioeconomic burden. The chemical investigation of Lavandula coronopifolia aerial parts extract using HPLC–MS/MS led to the tentative identification of 46 compounds belonging to phenolic acids, flavonoids and their glycosides, and biflavonoids. The extract displayed larvicidal activity against Culex pipiens larvae (LC₅₀ = 29.08 µg/mL at 72 h). It significantly inhibited cytochrome P-450 monooxygenase (CYP450), acetylcholinesterase (AChE), and carboxylesterase (CarE) enzymes with the comparable pattern to the control group, which could explain the mode of larvae toxification. The extract also inhibited the biofilm formation of Pseudomonas aeruginosa by 17–38% at different Minimum Inhibitory Concentrations (MICs) (0.5–0.125 mg/mL) while the activity was doubled when combined with ciprofloxacin (ratio = 1:1 v:v). In conclusion, the wild plant, L. coronopifolia, can be considered a promising natural source against resistant bacteria and infectious carriers.     

Accretion processes for general spherically symmetric compact objects

The European Physical Journal C - LArGe is a Gerda low-background test facility to study novel background suppression methods in a low-background environment, for future application in the Gerda...     

New sensitive spectrophotometric method for the determination of clomipramine-HCl in pure form and pharmaceutical preparations

A simple, rapid and sensitive spectrophotometric method for the assay of clomipramine-HCl is described. It has been found that clomipramine-HCl reacts with ammonium molybdate in acetic medium to give blue color product exhibiting maximum absorbance at 712 nm. The reaction is selective for clomipramine-HCl with 1 μg/mL as visual limit of detection. It provides a basis for a sensitive spectrophotometric method for the determination of clomipramine-HCl. The method obeys Beer’s Law from 0.001 to 0.250 mg/mL. The standard deviation does not exceed 0.005 mg/mL. The method has been successfully applied to the determination of clomipramine-HCl in pure form and pharmaceutical preparations. The quantitative assessment of tolerable amounts of possible interferants was also studied. The results are reproduced within ±1% and are in good agreement with those obtained by the standard procedure.     

以方沸石负载Ni(Ⅱ)催化剂修饰的电极电氧化甲醇(英文)

There is a high overvoltage in the oxidation of methanol in fuel cells,and so modified electrodes are used to decrease it.A modified electrode that used Ni(II) loaded analcime zeolite to catalyze the electrooxidation of methanol in alkaline solution was proposed.Analcime zeolite was synthesized by hydrothermal synthesis,and Ni(II) ions were incorporated into the analcime structure,which was then mixed with carbon paste to prepare modified electrode.The electrocatalytic oxidation of methanol on the surface of the modified electrode in alkaline solution was investigated by cyclic voltammetry and chronoamperometry.The effects of the scan rate of the potential,concentration of methanol,and amount of zeolite were investigated.The rate constant for the catalytic reaction of methanol was 6 × 103 cm3 mol-1 s-1 from measurements using chronoamperometry.The proposed electrode significantly improved the electron transfer rate and decreased the overpotential for methanol oxidation.     

Purification and Characterization of Pepsin-Solubilized Collagen from Skin of Sea Cucumber Holothuria parva

Pepsin-solubilized collagen (PSC) was extracted from the skin of sea cucumber Holothuria parva and was fractionally characterized. The PSC from H. parva skin consisted of three α₁ chains (α₁)₃, in contrast to calf skin collagen type I with two α₁ and one α₂ chains (α₁)₂α₂ with approximately 130 kDa each. The maximum transition (T_m) and denaturation temperature (T_d) of PSC were determined to be 46.94 and 32.5 °C, respectively. The amino acid composition analysis revealed that glycine, proline, alanine, and hydroxyproline were the abundant amino acids available in extracted PSC. The results showed that the isolated collagen from H. parva has some similar characteristics to previously reported collagens used in food and pharmaceutical industries.     

Static and dynamic light scattering of a random coil polymer in rodlike polymer solution

We have studied ternary solutions of rodlike and random coil polymers in a common solvent. In these solutions, the rods scatter weakly, and almost all scattering comes from the coil component. From light scattering measurements, we gained information about the thermodynamic and hydrodynamic properties of the coil in rodlike polymer solutions.     

Ultrasonic‐Assistance and Aging Time Effects on the Zeolitation Process of BZSM‐5 Zeolite

The isomorphic substitution of boron into ZSM‐5 zeolite under static hydrothermal condition was investigated. Evaluation of hydrothermal synthesis of BZSM‐5 was performed by treating the synthesis mixture by different aging processes, namely, ultrasonic, static, stirring, and microwave‐assisted aging prior to the conventional hydrothermal treatment. The synthetic processes with different techniques of aging prior to the onset of conventional hydrothermal crystallization were compared with a process without any prior aging. The obtained results showed that the ultrasonic and microwave assisted aging shortened the crystallization time and altered the crystal size and the morphology of the obtained products. The characteristics of the synthesized products were obtained by FT‐IR spectroscopic, XRD and SEM techniques.     

Multi-Fractal Formalism for Quasi-Self-Similar Functions

The study of multi-fractal functions has proved important in several domains of physics. Some physical phenomena such as fully developed turbulence or diffusion limited aggregates seem to exhibit some sort of self-similarity. The validity of the multi-fractal formalism has been proved to be valid for self-similar functions. But, multi-fractals encountered in physics or image processing are not exactly self-similar. For this reason, we extend the validity of the multi-fractal formalism for a class of some non-self-similar functions. Our functions are written as the superposition of similar structures at different scales, reminiscent of some possible modelization of turbulence or cascade models. Their expressions look also like wavelet decompositions. For the computation of their spectrum of singularities, it is unknown how to construct Gibbs measures. However, it suffices to use measures constructed according the Frostman's method. Besides, we compute the box dimension of the graphs.     

Interacting dark energy with inhomogeneous equation of state

We have investigated the model of dark energy interacting with dark matter by choosing inhomogeneous equations of state for the dark energy and a nonlinear interaction term for the underlying interaction. The equations of state have dependencies either on the energy densities, the redshift, the Hubble parameter or the bulk viscosity. We have considered these possibilities and have derived the effective equations of state for the dark energy in each case.