New Thiophene Derivatives as Antimicrobial Agents

Phenacylbromide derivatives constitute a multilateral group of precursors for the synthesis of numerous heterocycles of organic compounds. Briefly, 5‐(2‐bromo‐acetyl)‐substituted‐thiophene derivative has been used as a synthon for synthesis of new thiophene‐containing compounds through the reaction with nucleophilic nitrogen compounds and thioamides. The suggested structures of the newly synthesized thiophene compounds were confirmed and assured with different spectroscopic tools and with CHN elemental analysis. Additionally, the antimicrobial activity of these thiophene compounds was recorded to investigate their potency against various types of bacteria and fungi. Results showed that these compounds exhibit significant inhibitory activity against the growth of tested bacterial and fungal strains and that some derivatives were more potent than the employed reference drugs.     

Facile,one-pot,four-component synthesis of a new series of imidazo[1,2-a]pyridines in presence of TPAB in EtOH under reflux conditions

Research on Chemical Intermediates - A convenient, regioselective, novel, and elegant one-pot, four-component reaction was designed for synthesis of a series of new of imidazo[1,2-a]pyridines using...     

Multicomponent access to novel proline/cyclized cysteine tethered monastrol conjugates as potential anticancer agents

The versatility of multicomponent Biginelli’s reaction is exploited in the development of proline and cyclized cysteine tethered conjugates of monastrol, a kinesin Eg5 inhibitor. Ten new conjugates are synthesized focusing on structural replacement of the ester moiety (C-5 position) of the monastrol backbone with amino acid based amide moieties. On cytotoxic evaluation, conjugate 24 has shown promising in vitro cytotoxic activity against leukemia. Molecular docking studies revealed that the conjugates 19 and 24 exhibit better interaction at kinesin Eg5 receptor compared to monastrol. Moreover, computational calculations and predictions of important molecular properties suggest that these new amino acid based conjugates could be further improved to provide potential anticancer agents.     

Semi‐heterogeneous Dual Nickel/Photocatalysis using Carbon Nitrides: Esterification of Carboxylic Acids with Aryl Halides

Cross‐coupling reactions mediated by dual nickel/photocatalysis are synthetically attractive but rely mainly on expensive, non‐recyclable noble‐metal complexes as photocatalysts. Heterogeneous semiconductors, which are commonly used for artificial photosynthesis and wastewater treatment, are a sustainable alternative. Graphitic carbon nitrides, a class of metal‐free polymers that can be easily prepared from bulk chemicals, are heterogeneous semiconductors with high potential for photocatalytic organic transformations. Here, we demonstrate that graphitic carbon nitrides in combination with nickel catalysis can induce selective C?O cross‐couplings of carboxylic acids with aryl halides, yielding the respective aryl esters in excellent yield and selectivity. The heterogeneous organic photocatalyst exhibits a broad substrate scope, is able to harvest green light, and can be recycled multiple times. In situ FTIR was used to track the reaction progress to study this transformation at different irradiation wavelengths and reaction scales.     

Entanglement and Pancharatnam Phase for Two Two-Level Atoms Interacting with a Single Mode Field

A model of two 2-level atoms interacts with a single quantized electromagnetic field is considered. We study the effect of the mean photon number and the structure of the initial states of the two atoms on the dynamics of the atomic system from the separability point of view. It is found that, if we start from a product mixed atomic state, the probability of generating long living entangled states is increased as the mean photon number increases. Starting from excited atomic system in product state, one generates a more stable entangled states with high degree of entanglement. Also, the effect of the mean photon number on atomic system prepared initially in entangled states is investigated. It is found that the entangled state generated from the initially partial entangled states are more robust than those obtained from a maximum entangled state. The Pancharatnam phase for the separable and entangled states is studied under the effect of the mean photon number and the structure of the initial state. We find that for the separable states, the collapses decrease and the amplitude of the revivals is smaller than that for the entangled state, so there are long-living entangled phases. This property give us a great chances to store safely information in entangled state.     

Chemical characterisation of bioactive compounds in Medicago sativa growing in the desert of Oman

Medicago sativa Linn growing in Omani desert were chemically characterised using flame photometry, inductively coupled plasma, gas chromatography–mass spectrometry and high performance liquid chromatographic (HPLC) analysis. HPLC analyses were performed to determine the phenolics and flavonoids present in M. sativa. The major compounds detected in M. sativa leaves were protchaechenic acid (3.22%), hydroxyl benzoic acid (1.05%), β-Phenyl caffate (0.97%) and kaempherol (0.89%). Pterostilbene, a cholesterol-lowering compound, was detected in M. sativa.     

Stabilization of the wave equations with localized Kelvin–Voigt type damping under optimal geometric conditions

The purpose of this note is to investigate the stabilization of the wave equation with Kelvin–Voigt damping in a bounded domain. Damping is localized via a non-smooth coefficient in a suitable subdomain. We prove a polynomial stability result in any space dimension, provided that the damping region satisfies some geometric conditions. The main novelty of this note is that the geometric situations covered here are richer than that considered in [25], [22], [16] and include in particular an example where the damping region is not localized in a neighborhood of the whole or a part of the boundary.     

Experimental and numerical investigation of a stagnation pulverised coal flame

A multi-stream Flamelet Progress Variable (FPV) model, specifically developed for coal combustion, is proposed. The model accounts for the different fuel streams associated with the volatile and char burnout products. The applicability of the new FPV model is investigated in a laminar stagnation pulverized coal flame. The flame considered is a premixed mixture of CH₄, O₂ and N₂, carrying pulverized coal particles, stabilized in an impinging wall. Spontaneous emissions of OH*, CH* and C${}_2^{*}$ are measured to identify the flame. The 1D numerical simulations of the experimental conditions are able to reproduce the main features of the flame. The applicability of the multi-stream FPV model to coal combustion is further evaluated with the a posteriori analysis of the FPV results, comparing the results with a reference model, where the species are fully transported and the chemistry directly evaluated. Then, with the budget analysis, the influence of the control variables used to build the look-up table is assessed by examining the conditional contributions to the overall transport terms of scalar quantities (e.g. species, temperature). The results of both analyses show that the proposed multi-stream FPV model can accurately predict the main features of coal combustion, with only minor issues related to the manifold used to build the look-up table.     

Design and synthesis of certain substituted cycloalkanecarboxamides structurally related to safinamide with anticonvulsant potential

Research on Chemical Intermediates - A series of novel safinamide derivatives were synthesized and biologically evaluated for their anticonvulsant activity against maximal electroshock seizure...