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71.
We study the existence and properties of wormhole throats in modified f (R) gravity theory. Specifically, we concentrate on the cases where the lapse is not necessarily constant, and hence are not limited to the zero tidal force scenarios. In the class of theories whose actions are generated by Lagrangians of the form f (R)?=?∑ α n ?R n we find parameters which allow for the existence of energy condition respecting throats, which do not exist in Einstein gravity. We also consider the effect of the modified action on the anisotropy of the models, and find that modified gravity can minimize the amount of anisotropy required to support the existence of a throat. In both these respects, the sector containing theories with positive n is more promising than the negative n sector in comparison to Einstein gravity alone, with large n being most favorable. 相似文献
72.
An effective quantum field theory (QFT) with a manifest UV/IR connection, so as to be valid for arbitrarily large volumes, can successfully be applied to the cosmological dark energy problem as well as the cosmological constant (CC) problem. Motivated by recent approaches to the hierarchy problem, we develop such a framework with a large number of particle species. When applying to systems on the brink of experiencing a sudden collapse to a black hole, we find that the entropy, unlike the total energy, now becomes an increasing function of the number of field species. An internal consistency of the theory is then used to infer the upper bound on the number of particle species, showing consistency with the holographic Bekenstein–Hawking bound. This may thus serve to fill in a large gap in entropy of any non-black hole configuration of matter and the black holes. In addition, when the bound is saturated the entanglement entropy matches the black hole entropy, thus solving the multiplicity of species problem. In a cosmological setting, the maximum allowable number of species becomes a function of cosmological time, reaching its minimal value in a low-entropy post-reheating epoch. 相似文献
73.
Ivan Petters Matija Modruan Nikolina Vidovi Ivo Crnolatac Nikola Cindro Ivo Piantanida Giovanna Speranza Gordan Horvat Vladislav Tomii 《Molecules (Basel, Switzerland)》2022,27(12)
Cyclic pentaphenylalanine was studied as an efficient anion sensor for halides, thiocyanate and oxoanions in acetonitrile and methanol. Stability constants of the corresponding complexes were determined by means of fluorimetric, spectrophotometric, 1H NMR, and microcalorimetric titrations. A detailed structural overview of receptor–anion complexes was obtained by classical molecular dynamics (MD) simulations. The results of 1H NMR and MD studies indicated that the bound anions were coordinated by the amide groups of cyclopeptide, as expected. Circular dichroism (CD) titrations were also carried out in acetonitrile. To the best of our knowledge, this is the first example of the detection of anion binding by cyclopeptide using CD spectroscopy. The CD spectra were calculated from the structures obtained by MD simulations and were qualitatively in agreement with the experimental data. The stoichiometry of almost all complexes was 1:1 (receptor:anion), except for dihydrogen phosphate where the binding of dihydrogen phosphate dimer was observed in acetonitrile. The affinity of the cyclopeptide receptor was correlated with the structure of anion coordination sphere, as well as with the solvation properties of the examined solvents. 相似文献
74.
75.
tefica Horvat Lidija Varga Jaroslav Horvat Andreas Pfützner Haryadi Suhartono Helga Rübsamen-Waigmann 《Helvetica chimica acta》1991,74(5):951-955
A series of [Leu5]enkephalin-related glycoconjugates with an ester-, ether-, or amide-type linkage were synthesized and evaluated for antiviral activity against HIV-1 in a cell-culture system using peripheral blood lymphocytes. All tested glycoconjugates exhibited a certain antiviral activity which was significantly higher than the activity of the parent peptide compound itself. These results indicate that synthetic glycoconjugates of opioid peptides are good candidates for the development of anti-HIV agents. 相似文献
76.
Owing to the diversity of carbohydrate structures and their significance for the function of many biopolymers, structural analysis of various carbohydrate-related compounds is of great importance. Electrospray ionization tandem mass spectrometry (ESI-MS/MS) was used to establish the fragmentation behaviour of a range of sugar-peptide adducts as model compounds of widespread glycoprotein structures. The compounds used in this study were chosen to provide correlation of distinct fragment ions with specific structural differences, namely position and type of carbohydrate-peptide bond and structure of the sugar moiety. All compounds show N- and C-terminal sequence ions along with losses of up to three water molecules. Fructose-related Amadori compounds exhibit M + 78 modified N-terminal peptide fragment ions. Fragmentation of glucose-peptide esters is characterized by the sugar ring fragmentation. Additionally, under the ESI-MS conditions applied, the esters studied undergo intramolecular reaction giving cyclic sugar-peptide structures that can be traced by the presence of N-terminal peptide M + 42 adducts. Detailed analysis of cyclic fructose-related compound comprising structural features of both studied groups revealed a rich fragmentation pattern derived from amino acid residues and water molecules losses from [M - 2H(2)O + H](+) ion. Also, some interesting differences were found with respect to the nature of carbohydrate moieties. 相似文献
77.
Sandra Babi Alka J.M. Horvat Dragana Mutavdi Pavlovi Marija Katelan-Macan 《Trends in analytical chemistry : TRAC》2007,26(11):1043-1061
The acid dissociation constant is an important physicochemical parameter of a substance, and knowledge of it is of fundamental importance in a wide range of applications and research areas. We present a critical review of published methods and approaches for the determination of acid dissociation constants, with a special emphasis on the pKa values of active pharmaceutical ingredients. 相似文献
78.
Summary. Membrane-bound ATPases, such as Na,K-ATPase and nucleotide triphospho-diphosphohydrolase (NTPDase), being one of the first targets of a toxic action are generally considered as good markers for estimating toxicity. A
bioluminescence assay was applied for fast and sensitive evaluation of heavy metals effect on the rat brain synaptosomal membrane
ATPase activity. The assay consists of ATP-consuming reaction catalyzed by synaptic plasma membrane ATPases coupled to the luminescent firefly luciferase reaction, which consumes residual ATP after the course of ATPase reaction. The bioluminescence ATPase assay was applied to study the effect of heavy and transitional metals (Cu2+, Pb2+, Cd2+, Hg2+) on rat brain ATPase activity after assay optimization. All metals applied inhibited synaptic membrane ATPase activity in a concentration dependent manner. The IC
50 values (Hg2+ < Cu2+ < Cd2+ < Pb2+) obtained with the bioluminescence assay were highly correlated with those obtained by the spectrophotometric method. The
fast bioluminescence ATPase assay with small sample and substrate requirements could be adjusted for high-throughput environmental and pharmacological
screening. 相似文献
79.
Cveto Klofutar Jaka Horvat Darja Rudan-Tasic 《Monatshefte für Chemie / Chemical Monthly》2006,35(3):1151-1162
The apparent molar volume of rubidium, caesium, and ammonium cyclohexylsulfamate was determined from the density data of their
aqueous solutions at 293.15, 298.15, 303.15, 313.15, 323.15, and 333.15 K. From the apparent molar volume, determined at various
temperatures, the apparent molar expansibility was calculated. The limiting apparent molar volume and apparent molar expansibility
were evaluated and apportioned into their ionic components. The limiting partial molar ionic volumes and expansibilities are
discussed in terms of the various effects of the ion in solution on the structure of water. It was shown that the limiting
partial molar ionic expansibilities of the alkali-metal cations increase with their ionic radii. The coefficients of thermal
expansion of the investigated solutions at 298.15 K were calculated and are presented graphically together with some alkali-metal
cyclohexylsulfamates and tetramethylammonium cyclohexylsulfamate. The densities of the investigated solutions can be adequately
represented by an equation derived by Redlich. 相似文献
80.
Jaka Horvat Marija Bešter-Rogač Cveto Klofutar Darja Rudan-Tasic 《Journal of solution chemistry》2008,37(9):1329-1342
The viscosities of aqueous solutions of lithium, sodium, potassium, rubidium and caesium cyclohexylsulfamates were measured
at 293.15, 298.15, 303.15, 313.15 and 323.15 K. The relative viscosity data were analyzed and interpreted in terms of the
Kaminsky equation, η
r=1+Ac
1/2+Bc+Dc
2. The viscosity A-coefficient was calculated from the Falkenhagen-Dole theory. The viscosity B-coefficients are positive and relatively large. Their temperature coefficient ∂
B/∂
T is negative or near zero for lithium and sodium salts whereas for potassium, rubidium and caesium salts it is positive. The
viscosity D-coefficient is positive. This was explained by the size of the ions, structural solute–solute interactions, hydrodynamic
effect, and by higher terms of the long-range Debye-Hückel type of forces. From the viscosity B-coefficients the thermodynamic functions of activation of viscous flow were calculated. The limiting partial molar Gibbs
energy of activation of viscous flow of the solute was divided into contributions due to solvent molecules and the solute
in the transition state. The activation energy of the solvent molecules was calculated using the limiting Gibbs energy of
activation for the conductance of the solute ions. The activation energy of the solvent molecules was then discussed in terms
of the nature of the alkali-metal ions and their influence on the structure of water. The limiting activation entropy and
enthalpy of the solute for activation of viscous flow were interpreted by ion-solvent bond formation or breaking in the transition
state of the solvent. The hydration numbers of the investigated electrolytes were calculated from the specific viscosity of
the solutions. 相似文献