全文获取类型
收费全文 | 229篇 |
免费 | 9篇 |
专业分类
化学 | 170篇 |
力学 | 12篇 |
数学 | 21篇 |
物理学 | 35篇 |
出版年
2023年 | 4篇 |
2022年 | 2篇 |
2021年 | 12篇 |
2020年 | 5篇 |
2019年 | 8篇 |
2018年 | 7篇 |
2017年 | 5篇 |
2016年 | 12篇 |
2015年 | 8篇 |
2014年 | 5篇 |
2013年 | 9篇 |
2012年 | 10篇 |
2011年 | 14篇 |
2010年 | 7篇 |
2009年 | 7篇 |
2008年 | 6篇 |
2007年 | 5篇 |
2006年 | 9篇 |
2005年 | 7篇 |
2004年 | 10篇 |
2003年 | 2篇 |
2002年 | 2篇 |
2001年 | 4篇 |
2000年 | 6篇 |
1999年 | 2篇 |
1998年 | 5篇 |
1996年 | 2篇 |
1995年 | 3篇 |
1993年 | 2篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1984年 | 2篇 |
1980年 | 3篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1977年 | 3篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1974年 | 5篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1969年 | 2篇 |
1966年 | 1篇 |
1907年 | 2篇 |
1890年 | 1篇 |
排序方式: 共有238条查询结果,搜索用时 46 毫秒
21.
Manuela Zanetti Devid Maniglio Cristian Fasoli Marco Pola Elisa Borga Claudio Corradi Mauro Dalla Serra Salvatore Iannotta Antonella Motta Tullio Toccoli 《Electroanalysis》2014,26(8):1653-1659
We report the fabrication of a microfluidic apparatus and the realization of a sensors based on PEDOT : PSS, a biocompatible semiconductor polymer used in substitution of standard electrodes for electrophysiological studies and for detection of nanopores in membrane. This gives the possibility to study the mechanisms of ions balance and molecular transport though cell membranes. In particular the apparatus is based on two chambers connected through an aperture in a PTFE sheet where lipid bilayer are formed using Montal‐Mueller method, and the pore‐forming proteins activity is detected by polymeric electrodes. This methodology could be applied to examine different membrane proteins for the purpose of biosensing, drug screening and nanopore technologies. 相似文献
22.
BACKGROUND: Immunity against the T cell receptor (TCR) is considered to play a central role in the regulation of experimental allergic encephalomyelitis (EAE), a model system of autoimmune disease characterized by a restricted usage of TCR genes. Methods of specific vaccination against the TCR of pathogenetic T cells have included attenuated T cells and synthetic peptides from the sequence of the TCR. These approaches have led to the concept that anti-idiotypic immunity against antigenic sites of the TCR, which are a key regulatory element in this disease. METHODS: The present study in the Lewis rat used a conventional idiotypic immunization based on antigenized antibodies expressing selected peptide sequences of the Vbeta8.2 TCR (93ASSDSSNTE101 and 39DMGHGLRLIHYSYDVNSTEKG59). RESULTS: The study demonstrates that vaccination with antigenized antibodies markedly attenuates, and in some instances, prevents clinical EAE induced with the encephalitogenic peptide 68GSLPQKSQRSQDENPVVHF88 in complete Freunds' adjuvant (CFA). Antigenized antibodies induced an anti-idiotypic response against the Vbeta8.2 TCR, which was detected by ELISA and flowcytometry. No evidence was obtained of a T cell response against the corresponding Vbeta8.2 TCR peptides. CONCLUSIONS: The results indicate that antigenized antibodies expressing conformationally-constrained TCR peptides are a simple means to induce humoral anti-idiotypic immunity against the TCR and to vaccinate against EAE. The study also suggests the possibility to target idiotypic determinants of TCR borne on pathogenetic T cells to vaccinate against disease. 相似文献
23.
The study of the transport mechanisms connected to solid-liquid interactions is fundamental in the determination of the extension of the pollution of a site and in the evaluation of the best remediation process to be applied. The sorption of hydrophobic ionizable organic contaminants from the groundwaters is supervised not only by the physico-chemical properties of soil and pollutants, but also by the groundwaters pH, which deeply influences their solubility in the aqueous media, and consequently their transport mechanisms in the aquifer. In this work an experimental study of the sorption of phenol and 2-nitrophenol on two soils, different in particle-size distribution, CEC and organic carbon content, was realized. The sorption potential of the soils was evaluated by means of a physical, mineralogical and chemical characterization. The experimental data coming from some batch tests, performed at pH values equal to 4, 7 and 10 were fitted by means of linear, Freundlich and Langmuir isotherms models. The soil-contaminants interaction mechanisms that influence the isotherms shapes were then analyzed and discussed, and a comparison between the theoretical and experimental values of the partitioning coefficient KD was performed. 相似文献
24.
25.
Jacopo Stoppa 《Advances in Mathematics》2009,221(4):1397-1408
We show that a polarised manifold with a constant scalar curvature Kähler metric and discrete automorphisms is K-stable. This refines the K-semistability proved by S.K. Donaldson. 相似文献
26.
The miscibility-immiscibility phase transition in binary Bose-Einstein condensates (BECs) can be controlled by a coupling between the two components. Here we propose a new scheme that uses coupling-induced pattern formation to test the Kibble-Zurek mechanism (KZM) of topological-defect formation in a quantum phase transition. For a binary BEC in a ring trap we find that the number of domains forming the pattern scales as a function of the coupling quench rate with an exponent as predicted by the KZM. For a binary BEC in an elongated harmonic trap we find a different scaling law due to the transition being spatially inhomogeneous. We perform a "quantum simulation" of the harmonically trapped system in a ring trap to verify the scaling exponent. 相似文献
27.
28.
29.
30.
Jacopo La Nasa Marco Zanaboni Daniele Uldanck Ilaria Degano Francesca Modugno Hartmut Kutzke Eva Storevik Tveit Biljana Topalova-Casadiego Maria Perla Colombini 《Analytica chimica acta》2015
Modern oil paints, introduced at the beginning of the 20th century, differ from those classically used in antiquity in their chemical and compositional features. The main ingredients were still traditional drying oils, often used in mixtures with less expensive oils and added with several classes of additives. Consequently, detailed lipid profiling, together with the study of lipid degradation processes, is essential for the knowledge and the conservation of paint materials used in modern and contemporary art. 相似文献