Asymptotic representations of solutions of one class of second-order ordinary differential equations

We establish asymptotic representations for some classes of solutions of nonautonomous second-order differential equations close, in a certain sense, to linear equations.     

Facile synthesis of metal-organic framework films via in situ seeding of nanoparticles

A facile in situ nanoparticle seeding method is reported to prepare MIL-101(Cr) films on alumina supports. The in situ seeding of MIL-101(Cr) nanoparticles was promoted by use of dimethylacetamide (DMA). The generality of this approach is further demonstrated for Cu(3)(btc)(2) films by using a (poly)acrylate promoter.     

Guiding Drugs to Target‐Harboring Organelles: Stretching Drug‐Delivery to a Higher Level of Resolution

The ratio between the dose of drug required for optimal efficacy and the dose that causes toxicity is referred to as the therapeutic window. This ratio can be increased by directing the drug to the diseased tissue or pathogenic cell. For drugs targeting fungi and malignant cells, the therapeutic window can be further improved by increasing the resolution of drug delivery to the specific organelle that harbors the drug's target. Organelle targeting is challenging and is, therefore, an under‐exploited strategy. Here we provide an overview of recent advances in control of the subcellular distribution of small molecules with the focus on chemical modifications. Highlighted are recent examples of active and passive organelle‐specific targeting by incorporation of organelle‐directing molecular determinants or by chemical modifications of the pharmacophore. The outstanding potential that lies in the development of organelle‐specific drugs is becoming increasingly apparent.     

The impact of consanguinity worldwide

Consanguineous marriages have been practiced for hundreds of years in many parts of the world. The rate of congenital malformations among the offspring is 2.5 times higher than that among the offspring of unrelated parents, mainly due to the expression of autosomal-recessive disorders, and hospitalization for these reasons causes a major financial burden. An increase in sterility and in the rates of abortion, stillbirths, perinatal losses and neonatal deaths has been reported by some authors but not by others. It is generally accepted that the advantages of consanguinity outweigh the disadvantages; however, strategies for reducing the burden require a unique approach as discussed in this article.     

Novel polyesters and polyester/Cloisite 30B nanocomposites based on a new rhodanine-based monomer

A novel bis-diol monomer, 3,3'-bis-(2-hydroxyethyl)-2,2'-dithioxo-[5,5']bithiazolidinylidene-4,4'-dione, was prepared in a one-pot three component reaction and used in a polyesterification reaction with various aromatic dicarboxylic acids using tosyl chloride/dimethylformamide/pyridine system as a condensing agent in order to generate a series of new polyesters. The prepared polyesters were characterized by FTIR spectroscopy and elemental analysis. In the next part, a series of polyester/clay nanocomposites were synthesized through a polyesterification reaction of the synthesized monomer with iso-phthalic acid. Cloisite 30B was used as the filler at different concentrations. Wide-angle X-ray diffraction and transmission electron microscopy studies showed that the organoclay layers are mainly exfoliated in the nanocomposites containing 1 wt % of Cloisite 30B.     

Synthesis of a novel magnetic nanocatalyst based on rhodium complex for transfer hydrogenation of ketone

A magnetic heterogeneous nanocatalyst based on novel rhodium complex is designed. The transfer hydrogenation of ketones with 2‐propanol as hydrogen donor and the rhodium complex as nanocatalyst was achieved. High yields of ketones under mild conditions were obtained from easily available precursors.     

Preparation of an organic–inorganic hybrid based on synergy of Brønsted and Lewis acid centres as heterogeneous magnetic nanocatalyst for ultrafast synthesis of acetaminophen

A heterogeneous nanocatalyst based on a Cu(II) complex containing phosphotungstic acid and N/O‐donor ligands supported on cobalt ferrite nanoparticles was successfully prepared. The synthesized nanocatalyst was characterized using various techniques. The magnetic nanocatalyst was examined as an efficient and synergistic catalyst for ultrafast synthesis of acetaminophen at room temperature and under solventless conditions. The examined synergistic nanocatalyst, which has both Lewis and Brønsted acidic sites, could be easily separated from the reaction system and reused several times without significant loss of its activity. The synthesized acetaminophen was also fully characterized.