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排序方式: 共有480条查询结果,搜索用时 15 毫秒
101.
A series of tetrachloride platinum(IV) compounds of the general formulae PtCl4L2, where L = 1,2,4-triazolo[1,5-a]pyrimidine (tp) (1), 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine (dmtp) (2), 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine (dbtp) (3) and 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one (HmtpO) (4) have been prepared and characterized by thermal analysis, 1H, 13C, 15N, 195Pt NMR and IR spectroscopy. Spectral data suggest that the triazolopyrimidines act as a monodentate ligand via the nitrogen atom N(3). The preliminary assessments of antitumor properties of the four complexes were evaluated as in vitro antiproliferative activity against three cell lines: HL-60 human acute promyelocytic leukemia, SW707 rectal adenocarcinoma and HCV29T bladder cancer. PtCl4(dbtp)2 exhibits high cytotoxic activity against all human cell lines, whereas the other complexes are only moderately active. 相似文献
102.
This paper presents a comparison of certain direct algorithms for computing the Moore-Penrose inverse, for matrices of full column rank, from the point of view of numerical stability. It is proved that the algorithm using Householder QR decomposition, implemented in floating point arithmetic, is forward stable but only conditionally mixed forward-backward stable. A similar result holds also for the Classical Gram-Schmidt algorithm with reorthogonalization (CGS2). This algorithm was developed and analyzed by Abdelmalek (BIT, 11(4):354–367, 1971) and its detailed error analysis was given in Giraud et al. (Numer. Math. 101(1):87–100, 2005). 相似文献
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Berdys J Anusiewicz I Skurski P Simons J 《Journal of the American Chemical Society》2004,126(20):6441-6447
Although electrons having enough energy to ionize or electronically excite DNA have long been known to cause strand breaks (i.e., bond cleavages), only recently has it been suggested that even lower-energy electrons (most recently 1 eV and below) can also damage DNA. The findings of the present work suggest that, while DNA bases can attach electrons having kinetic energies in the 1 eV range and subsequently undergo phosphate-sugar O-C sigma bond cleavage, it is highly unlikely (in contrast to recent suggestions) that electrons having kinetic energies near 0 eV can attach to the phosphate unit's P=O bonds. Electron kinetic energies in the 2-3 eV range are required to attach directly to DNA's phosphate group's P=O pi orbital and induce phosphate-sugar O-C sigma bond cleavages if the phosphate groups are rendered neutral (e.g., by nearby counterions). Moreover, significant activation barriers to C-O bond breakage render the rates of both such damage mechanisms (i.e., P=O-attached and base-attached) slow as compared to electron autodetachment and to other damage processes. 相似文献
105.
Spectrochemical Properties of Cobalt(II) Complex with Bidentate Schiff Base in Various Solvents 总被引:1,自引:0,他引:1
Krzysztof Kurzak Iwona Kuźniarska-Biernacka Bogumila Żurowska 《Journal of solution chemistry》1999,28(2):133-151
As a continuation of our previous studies on copper(II) complexes with a bidentate Schiff base derived from 5-bromosalicylaldehyde and -aminopyridine, we have investigated the electronic spectra of the cobalt(II) complex with this ligand. The complex is a red crystalline compound soluble in common solvents, such as chloroform, dioxane, dimethyl formamide, dimethyl sulfoxide, and methanol. The time-elapsed spectral measurements of the complex and ligand, as well as conductivities of the complex in chloroform and dioxane solutions, are presented and discussed. Molar conductivities indicate that the complex exists as a nonelectrolyte in nonpolar solvents and as a 1:1 or 1:2 electrolyte in polar solvents. The ligand-field parameters (CFM/AOM) for the complex in chloroform solution are estimated and discussed. 相似文献
106.
Klaudia Kowalik Magdalena Polak-Berecka Monika Prendecka-Wrbel Dominika Pigo-Zajc Iwona Nied
wied
Dominik Szwajgier Ewa Baranowska-Wjcik Adam Wako 《Molecules (Basel, Switzerland)》2022,27(3)
The biological activity of an in vitro digested infusion of Epilobium angustifolium (fireweed) was examined in a model system of intestinal epithelial and colon cancer tissues. The content of selected phenolic compounds in the digested aqueous extract of fireweed was determined using HPLC-ESI-QTOF-MS/MS. Biological activity was examined using the human colon adenocarcinoma cell lines HT-29 and CaCo-2 and the human colon epithelial cell line CCD 841 CoTr. Cytotoxicity was assessed by an MTT assay, a Neutral Red uptake assay, May-Grünwald-Giemsa staining, and a label-free Electric Cell-Substrate Impedance Sensing cytotoxicity assay. The effect of the infusion on the growth of selected intestinal bacteria was also examined. The extract inhibited the growth of intestinal cancer cells HT-29. This effect can be attributed to the activity of quercetin and kaempferol, which were the most abundant phenolic compounds found in the extract after in vitro digestion. The cytotoxicity of the fireweed infusion was dose-dependent. The highest decrease in proliferation (by almost 80%) compared to the control was observed in HT-29 line treated with the extract at a concentration of 250 μg/mL. The fireweed infusion did not affect the growth of beneficial intestinal bacteria, but it did significantly inhibit E. coli. The cytotoxic effect of the fireweed extract indicates that it does not lose its biological activity after in vitro digestion. It can be concluded that the fireweed infusion has the potential to be used as a supporting agent in colon cancer therapy. 相似文献
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109.
Dr. Iwona Nierengarten Marc Nothisen Dr. David Sigwalt Thomas Biellmann Dr. Michel Holler Dr. Jean‐Serge Remy Dr. Jean‐François Nierengarten 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(51):17552-17558
Dendritic pillar[5]arene derivatives have been efficiently prepared by grafting dendrons with peripheral Boc‐protected amine subunits onto a preconstructed pillar[5]arene scaffold. Upon cleavage of the Boc‐protected groups, water‐soluble pillar[5]arene derivatives with 20 ( 13 ) and 40 ( 14 ) peripheral ammonium groups have been obtained. The capability of these compounds to form stable nanoparticles with plasmid DNA has been demonstrated by gel electrophoresis, transmission electron microscopy (TEM), and dynamic light scattering (DLS) investigations. Transfection efficiencies of the self‐assembled 13 /pCMV‐Luc and 14 /pCMV‐Luc polyplexes have been evaluated in vitro with HeLa cells. The transfection efficiencies found for both compounds are good, and pillar[5]arenes 13 and 14 show very low toxicity if any. 相似文献
110.
Dr. Ottavia Bettucci Dr. Jorge Pascual Dr. Silver-Hamill Turren-Cruz Andrea Cabrera-Espinoza Dr. Wakana Matsuda Dr. Sebastian F. Völker Hans Köbler Dr. Iwona Nierengarten Dr. Gianna Reginato Dr. Silvia Collavini Prof. Shu Seki Prof. Jean-François Nierengarten Prof. Antonio Abate Prof. Juan Luis Delgado 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(31):8110-8117
Multi-branched molecules have recently demonstrated interesting behaviour as charge-transporting materials within the fields of perovskite solar cells (PSCs). For this reason, extended triarylamine dendrons have been grafted onto a pillar[5]arene core to generate dendrimer-like compounds, which have been used as hole-transporting materials (HTMs) for PSCs. The performances of the solar cells containing these novel compounds have been extensively investigated. Interestingly, a positive dendritic effect has been evidenced as the hole transporting properties are improved when going from the first to the second-generation compound. The stability of the devices based on the best performing pillar[5]arene material has been also evaluated in a high-throughput ageing setup for 500 h at high temperature. When compared to reference devices prepared from spiro-OMeTAD, the behaviour is similar. An analysis of the economic advantages arising from the use of the pillar[5]arene-based material revealed however that our pillar[5]arene-based material is cheaper than the reference. 相似文献