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851.
Iva Habinovec Ivana Mikulandra Lucia Ema Sekula Jana Gaperov Saa Kazazi Predrag Novak 《Molecules (Basel, Switzerland)》2021,26(20)
LC-SPE/cryo NMR and MS methodologies have been developed and employed for a rapid structure determination of 4″-tetrahydrofurfuryl macrozone reaction mixture components. Macrozones, novel conjugates of azithromycin, and thiosemicarbazones have shown very good in vitro antibacterial activities against susceptible and some resistant bacterial strains and are promising agents for further development. The post-column multiple trapping of the chromatographically separated reaction mixture components on the SPE cartridges increased the sensitivity and together with cryogenically cooled NMR probe made it possible to identify and structurally characterize main 4″-tetrahydrofurfuryl macrozone reaction mixture compounds including those present at very low concentration level. This approach has several advantages over a classical off-line procedure, efficiency and low solvent consumption being the two most important ones. All identified components were process-related. It has been demonstrated that two different kinds of compounds with respect to structure were identified, i.e., macrolide-related and thiosemicarbazone-related ones. This methodology can serve as a platform for reliable and effective macrolides reaction components structure profiling, serving as both isolation and identification tools. 相似文献
852.
853.
Nonlinear Dynamics - Linear time-delay feedback method makes the stable system generate the infinite-dimensional hyper-chaos, which possesses more than one positive Lyapunov exponent,... 相似文献
854.
Ivana Barravecchia Elisabetta Barresi Camilla Russo Francesca Scebba Chiara De Cesari Valerio Mignucci Davide De Luca Silvia Salerno Valeria La Pietra Mariateresa Giustiniano Sveva Pelliccia Diego Brancaccio Greta Donati Federico Da Settimo Sabrina Taliani Debora Angeloni Luciana Marinelli 《Molecules (Basel, Switzerland)》2021,26(24)
Molecule interacting with CasL 2 (MICAL2), a cytoskeleton dynamics regulator, are strongly expressed in several human cancer types, especially at the invasive front, in metastasizing cancer cells and in the neo-angiogenic vasculature. Although a plethora of data exist and stress a growing relevance of MICAL2 to human cancer, it is worth noting that only one small-molecule inhibitor, named CCG-1423 (1), is known to date. Herein, with the aim to develop novel MICAL2 inhibitors, starting from CCG-1423 (1), a small library of new compounds was synthetized and biologically evaluated on human dermal microvascular endothelial cells (HMEC-1) and on renal cell adenocarcinoma (786-O) cells. Among the novel compounds, 10 and 7 gave interesting results in terms of reduction in cell proliferation and/or motility, whereas no effects were observed in MICAL2-knocked down cells. Aside from the interesting biological activities, this work provides the first structure–activity relationships (SARs) of CCG-1423 (1), thus providing precious information for the discovery of new MICAL2 inhibitors. 相似文献
855.
Rudolf Polk Ivana Paidarov Vladimír Sîpirko Philip J. Kuntz 《International journal of quantum chemistry》1996,57(3):429-440
To provide a potential energy surface (PES ) for a three-dimensional vibrational model of the dissociation dynamics of ammonia in the à state, accurate MRD-CI computations were carried out for a wide range of displacements in the out-of-plane and in-plane bending coordinates along the H(bond)NH2 dissociation coordinate. Some characteristic features of the Ã-state PES , such as the height and position of the barrier to dissociation and the dependence of the PES on the out-of-plane angle, differ noticeably from earlier work on this system. The values for the height of the barrier computed from the MRD-CI extrapolation, full CI , and secular equation estimates are 0.38, 0.34, and 0.32 eV, respectively. © 1996 John Wiley & Sons, Inc. 相似文献
856.
Lara Zori Nika Drinkovi Vedran Micek Leo Frkanec Akif Emre Türeli Nazende Günday-Türeli Ivana Vinkovi Vr
ek Rua Frkanec 《Molecules (Basel, Switzerland)》2022,27(4)
Doxorubicin (DOX) is one of the most effective cytotoxic agents against malignant diseases. However, the clinical application of DOX is limited, due to dose-related toxicity. The development of DOX nanoformulations that significantly reduce its toxicity and affect the metabolic pathway of the drug requires improved methods for the quantitative determination of DOX metabolites with high specificity and sensitivity. This study aimed to develop a high-throughput method based on high-performance liquid chromatography with fluorescence detection (HPLC-FD) for the quantification of DOX and its metabolites in the urine of laboratory animals after treatment with different DOX nanoformulations. The developed method was validated by examining its specificity and selectivity, linearity, accuracy, precision, limit of detection, and limit of quantification. The DOX and its metabolites, doxorubicinol (DOXol) and doxorubicinone (DOXon), were successfully separated and quantified using idarubicin (IDA) as an internal standard (IS). The linearity was obtained over a concentration range of 0.05–1.6 μg/mL. The lowest limit of detection and limit of quantitation were obtained for DOXon at 5.0 ng/mL and 15.0 ng/mL, respectively. For each level of quality control (QC) samples, the inter- and intra-assay precision was less than 5%. The accuracy was in the range of 95.08–104.69%, indicating acceptable accuracy and precision of the developed method. The method was applied to the quantitative determination of DOX and its metabolites in the urine of rats treated by novel nanoformulated poly(lactic-co-glycolic acid) (DOX-PLGA), and compared with a commercially available DOX solution for injection (DOX-IN) and liposomal-DOX (DOX-MY). 相似文献
857.
Martinia Ira Glogar Tihana Dekani Anita Tarbuk Ivana orak Petra Labazan 《Molecules (Basel, Switzerland)》2022,27(4)
The paper examines the influence of cotton cationization on the print quality in terms of penetration, colour yield and colour depth, which have been analysed in comparison to cotton untreated and pretreated with conventional acrylate binder. The process of cationization during mercerization was performed with a cationizing agent Rewin DWR (CHT Bezema). Standard (non-cationized) and cationized fabric, with and without additional layering of binder have been printed by digital inkjet pigment printing method. Moisture management testing (MMT) and dynamic contact angle measurement (drop shape analyzer–DSA30S) were performed on standard and cationized fabric, with and without binder, both with and without pigment layer. After printing, the objective values of colour depth (K/S) and colour parameters L*, C* and h° were analysed. The samples were also analysed by the method of microscopic imaging using a DinoLite microscope. Printed samples were tested to washing fastness, and the results are presented in terms of total colour difference (dECMC), according to CMC(l:c) equation, after the 1st, 3rd, 5th, 7th and 10th washing cycles. Results showed that the cotton cationization will improve the uniformity and coverage of the printed area as well as increase the K/S value. For the samples with binder, the positive effect of cationization on the stability and bond strength between the polymer layer as a pigment carrier with the cotton fabric was confirmed. 相似文献
858.
Evgeniy Toropitsyn Ivana Ščigalková Martin Pravda Vladimír Velebný 《Macromolecular bioscience》2023,23(4):2200516
Osteoarthritisis a highly prevalent musculoskeletal disorder characterized by degradation of cartilage and synovial fluid (SF). Platelet derivatives as platelet-rich plasma (PRP) and platelet lysate have great potential in the treatment of osteoarthritis because they contain biologically active substances including growth factors (GFs). Rapid release of GFs and their short biological half-life are factors that can limit the therapeutic impact of PRP therapy. Herein, the first work that describes hydrogels based on polyaldehyde derivative of hyaluronic acid (HA-OX) as carriers of platelet derivatives for in situ applications is presented, which can be a possible solution to the problem. HA-OX hydrogels containing 50% (w/w) of PRP or platelet lysate can be injected using a syringe due to low viscosity(<10 Pa s) and injection force (<20 N), and reach elastic modulus up to 2000 Pa. Insulin-like GF-1 and Platelet-derived GF-AB release from HA-OX hydrogels (mesh size 297–406 nm) by Fickian and non-Fickian diffusion respectively. The released PRP GFs maintain their ability to induce cell proliferation (87%–92%). Based on the obtained results, the unique concept of a new material that can restore viscoelastic properties of SF and at the same time gradually deliver GFs from platelet derivatives is designed. 相似文献
859.
Ivana Marić Liangliang Yang Xiufeng Li Guillermo Monreal Santiago Charalampos G. Pappas Xinkai Qiu Joshua A. Dijksman Kirill Mikhailov Patrick van Rijn Sijbren Otto 《Angewandte Chemie (International ed. in English)》2023,62(14):e202216475
Dynamic covalent chemistry (DCC) has proven to be a valuable tool in creating fascinating molecules, structures, and emergent properties in fully synthetic systems. Here we report a system that uses two dynamic covalent bonds in tandem, namely disulfides and hydrazones, for the formation of hydrogels containing biologically relevant ligands. The reversibility of disulfide bonds allows fiber formation upon oxidation of dithiol-peptide building block, while the reaction between NH−NH2 functionalized C-terminus and aldehyde cross-linkers results in a gel. The same bond-forming reaction was exploited for the “decoration” of the supramolecular assemblies by cell-adhesion-promoting sequences (RGD and LDV). Fast triggered gelation, cytocompatibility and ability to “on-demand” chemically customize fibrillar scaffold offer potential for applying these systems as a bioactive platform for cell culture and tissue engineering. 相似文献
860.
Lea Vuletić Ivana Lapić Stjepan Špalj Iva Marolt Banek Domagoj Jakovac Jasmina Šipkar Dunja Rogić 《Electroanalysis》2023,35(5):e202200399
Ion-selective electrode pocket meters available for use with saliva could be a convenient tool to assess how diseases, drugs, exercise or nutrition affect salivary composition. This study compared salivary sodium and potassium concentrations measured by handheld LAQUAtwin meters and a fully-automated biochemical analyzer. Agreement between two methods was assessed with Passing-Bablok regression and Bland-Altman plots. LAQUAtwin meters measured lower values of both analytes and provided repeatable though not accurate results. The meters may serve as an alternative to laboratory methods to gain insight into between-group differences in electrolyte concentrations, or a concentration change induced by an experimental procedure. 相似文献