Biological X‐ray absorption spectroscopy and metalloproteomics

In the past seven years the size of the known protein sequence universe has been rapidly expanding. At present, more then five million entries are included in the UniProtKB/TrEMBL protein database. In this context, a retrospective evaluation of recent X‐ray absorption studies is undertaken to assess its potential role in metalloproteomics. Metalloproteomics is the structural and functional characterization of metal‐binding proteins. This is a new area of active research which has particular relevance to biology and for which X‐ray absorption spectroscopy is ideally suited. In the last three years, biological X‐ray absorption spectroscopy (BioXAS) has been included among the techniques used in post‐genomics initiatives for metalloprotein characterization. The emphasis of this review is on the progress in BioXAS that has emerged from recent meetings in 2007–2008. Developments required to enable BioXAS studies to better contribute to metalloproteomics throughput are also discussed. Overall, this paper suggests that X‐ray absorption spectroscopy could have a higher impact on metalloproteomics, contributing significantly to the understanding of metal site structures and of reaction mechanisms for metalloproteins.     

Quasi-Gaussian beam from a multicore fibre laser by phase locking of supermodes

We present a new cavity design for controlling the spatial quality of the beam delivered by a fibre laser including a multicore fibre. A quasi Gaussian profile is produced at the 7-core fibre output involving self-imaging effects in the multicore fibre and spatial filtering. Numerical and experimental investigations analyse the spatial and spectral characteristics of the multicore fibre laser.     

Gasanalyse

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Über die aus Hydrochinon in der Natronschmelze entstehenden Körper

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Eine neue Normal-Mostwage

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Über Mesitylendisulfosäure

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Über die Einwirkung von schmelzendem Atznatron auf Orcin und Gallussäure

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