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81.
Fernando Dures Patrícia M. A. Silva Pedro Novais Isabel Amorim Luís Gales Ctia I. C. Esteves Samuel Guieu Hassan Bousbaa Madalena Pinto Emília Sousa 《Molecules (Basel, Switzerland)》2021,26(11)
Thioxanthones are bioisosteres of the naturally occurring xanthones. They have been described for multiple activities, including antitumor. As such, the synthesis of a library of thioxanthones was pursued, but unexpectedly, four tetracyclic thioxanthenes with a quinazoline–chromene scaffold were obtained. These compounds were studied for their human tumor cell growth inhibition activity, in the cell lines A375-C5, MCF-7 and NCI-H460. Photophysical studies were also performed. Two of the compounds displayed GI50 values below 10 µM for the three tested cell lines, and structure–activity relationship studies were established. Three compounds presented similar wavelengths of absorption and emission, characteristic of dyes with a push-pull character. The structures of two compounds were elucidated by X-ray crystallography. Two tetracyclic thioxanthenes emerged as hit compounds. One of the two compounds accumulated intracellularly as a bright fluorescent dye in the green channel, as analyzed by both fluorescence microscopy and flow cytometry, making it a promising theranostic cancer drug candidate. 相似文献
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83.
Isabel Pizarro Ma Milagros Gomez Carmen Cámara Ma Antonia Palacios 《International journal of environmental analytical chemistry》2013,93(10):879-890
Gradient ion chromatographic separation coupled with ICP-MS was used to resolve and determine the most common arsenic species in environmental and biological samples of carrots, trout, soil, sediment and river water from Region II of Chile. The carrot and trout samples showed a concentration of 49 and 168 µg g?1, respectively, of total As. Both concentrations are high considering the basal level. In the carrots, percentage of 45 and 31% of total As were found for As(III) and As(V) species, respectively. In the trout, the higher concentration related to AsB at 39% of the total As. As(III) and DMA were also present in relatively high concentrations. The River Loa and the soil in which the carrots are growing also present very high As(V) concentrations of 100 and 17 µg g?1, respectively. The ratio between the concentration for the same As species found in the living organisms (carrots and trout) and the environment in which they grow (soil and water) can provide important information about the possible absorption or biotransformation of As species in living beings. As(III) and DMA are the species in which the greatest accumulation occurs with respect to the medium in which they are present, and biotransformation also appears to take place. 相似文献
84.
In recent years, there has been an increase of infectious diseases caused by different microorganisms and the development of antibiotic resistance. In this way, the search for new and efficient antibacterial materials is imperative. The main polysaccharides currently used in the biomedical and pharmaceutical domains are chitin and its derivative chitosan (CH) and alginates (ALG). In this study, a simple technique of Layer by Layer (LbL) of applying polycation CH and polyanion ALG was used to prepare CH/ALG multilayers on cotton samples via the electrostatic assembly with success. The CH/ALG cotton samples (functionalized) were investigated for their antibacterial properties towards Staphylococcus aureus and Klebsiella pneumonia using the international standard method JIS L 1902:2002. The antibacterial activity of the functionalized samples was tested in terms of bacteriostatic and bactericidal activity, and results showed that the samples exhibited a bacteriostatic effect on the two bacteria tested, as expected. In addition, samples with five layers (CH/ALG/CH/ALG/CH) were more effective in inhibiting bacterial growth. This new coating for cellulosic fibers is a new strategy and may open new avenues for the development of antimicrobial polymers with potential application in health‐care field. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
85.
The steady-state fluorescence emission from the local anaesthetic tetracaine (TCA) in water–solvent mixtures and in the presence of α-, β- and γ-cyclodextrin (CD) was investigated at various pH values. Emission was observed from the locally and the intramolecular charge transfer excited states. The TCA–CD system was found to be characterised by 1:1 associate in every case. The association constants of each complex were determined. 相似文献
86.
Montecrinanes A–C: Triterpenes with an Unprecedented Rearranged Tetracyclic Skeleton from Celastrus vulcanicola. Insights into Triterpenoid Biosynthesis Based on DFT Calculations
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Dr. Martín Purino Dr. Alejandro E. Ardiles Dr. Oliver Callies Dr. Ignacio A. Jiménez Prof. Isabel L. Bazzocchi 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(22):7582-7591
Three new triterpenoids with an unprecedented 6/6/6/6‐fused tetracyclic carbon skeleton, montecrinanes A–C ( 1 – 3 ), were isolated from the root bark of Celastrus vulcanicola, along with known D:B‐friedobaccharanes ( 4 – 6 ), and lupane‐type triterpenes ( 7 – 12 ). The stereostructures of the new metabolites were elucidated based on spectroscopic (1D and 2D NMR) and spectrometric (HR‐EIMS and HR‐ESIMS) techniques. Their absolute configurations were determined by both NMR spectroscopy, with (R)‐(?)‐α‐methoxyphenylacetic acid as a chiral derivatizing agent, and biogenetic considerations. Biogenetic pathways for montecrinane and D:B‐friedobaccharane skeletons were proposed and studied by DFT methods. The theoretical results support the energetic feasibility of the putative biogenetic pathways, in which the 1,2‐methyl shift from the secondary baccharenyl cation represents a novel and key reaction step for a new montecrinane skeleton. 相似文献
87.
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ZDM – Mathematics Education - This study highlights the importance of cognition-affect interaction pathways in the construction of mathematical knowledge. Scientific output demands further... 相似文献
89.
On-vial immobilized CdSe quantum dots (QDs) are applied for the first time as chemiluminescent probes for the detection of trace metal ions. Among 17 metal ions tested, inhibition of the chemiluminescence when CdSe QDs are oxidized by H2O2 was observed for Sb, Se and Cu. Liquid–liquid–liquid microextraction was implemented in order to improve the selectivity and sensitivity of the chemiluminescent assay. 相似文献
90.
Julia Vallejo Alejandro Pascual‐Álvarez Dr. Joan Cano Dr. Isabel Castro Prof. Dr. Miguel Julve Prof. Dr. Francesc Lloret Dr. J. Krzystek Prof. Dr. Giovanni De Munno Dr. Donatella Armentano Prof. Dr. Wolfgang Wernsdorfer Dr. Rafael Ruiz‐García Dr. Emilio Pardo 《Angewandte Chemie (International ed. in English)》2013,52(52):14075-14079