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981.
Abstract The current review covers explosive development of various synthetic approaches for piperidine scaffold and its analogues in the last few decades. The piperidine ring system is a key motif in many natural alkaloids and synthetic organic compounds. Further, piperidine moiety has gained significant consideration in drug discovery due to its wide range of therapeutic applications. 相似文献
982.
Mehroz Iqbal Jameela Fatheema Qandeel Noor Malika Rani Muhammad Mumtaz Ren-Kui Zheng Saleem Ayaz Khan Syed Rizwan 《Materials Today Chemistry》2020
This study reports first synthesis of MXene-derived co-existing magnetic phases. New family of two-dimensional (2D) materials such as Ti3C2 namely MXene, having transition metal forming hexagonal structure with carbon atoms have attracted tremendous interest now a days. We have reported structural, optical and magnetic properties of un-doped and La-doped Ti3C2Tx MXene, synthesized using co-precipitation method. The lattice parameter (LP) calculated for La-MXene are a = 5.36 Å, c = 18.3 Å which are slightly different from the parent un-doped MXene (a = 5.35 Å, c = 19.2 Å), calculated from X-ray diffraction data. The doping of La+3 ions shrinks Ti3C2Tx layers perpendicular to the planes. The band gap for MXene is calculated to be 1.06 eV which is increased to 1.44 eV after doping of La+3 ion that shows its good semiconducting nature. The experimental results and density functional theory (DFT) calculations for magnetic properties of both the samples have been presented and discussed, indicating the co-existence of ferromagnetic-antiferromagnetic phases. The results presented here are novel and is first report on co-existence of magnetic properties of 2D carbides for potential applications in two-dimensional spintronics. 相似文献
983.
T. Iqbal B. J. Briscoe S. Yasin P. F. Luckham 《Journal of Macromolecular Science: Physics》2014,53(9):1522-1532
A systematic experimental study of the large strain surface mechanical properties of a number of polymers {polymethylmethacrylate (PMMA), polyetheretherketone (PEEK), polystyrene (PS), polycarbonate (PC), polypropylene (PP), and ultra-high molecular weight polyethylene (UHMWPE)} at the nanometer scale is described. The polymeric surfaces were indented and the data were analyzed using a contact compliance method in conjunction with a nano-indenter system. The indentation experiments were performed using a Berkovich Tip indenter with a continuous contact compliance indentation mode. The indentations were performed using a constant loading rate (300 μN/sec) to a maximum penetration depth of 5 μm. The experimental results showed a considerable strain-rate hardening effect for the polymers and a peculiarly harder response of these surfaces at the near-to-surface (submicron) layers. PMMA was the hardest polymer of the selection, whereas UHMWPE and PP were observed to be the softest polymers. The paper includes practical consideration of a creeping effect and appropriateness of tip calibration using harder surfaces for nanoindentation experimentation of polymers. 相似文献
984.
985.
Seven secondary metabolites, p-hydroxybenzoic acid (1), 3,4-dihydroxybenzoic acid (2), ferulic acid (3), 2,6-dimethoxy-4-hydroxy acetophenone (4), lupeol (5), 2'-O-ethylmurrangatin (6) and hibiscetin heptamethyl ether (7) were the natural products isolated from various medicinal plants. Their structures were identified by spectral comparison with previously reported data. The compounds 1-7 were screened for their tyrosinase-inhibitory activity. The compound p-hydroxybenzoic acid (1) was found to have potent activity against tyrosinase enzyme, whereas lupeol (5) showed significant activity. 相似文献
986.
Kamdem RS Wafo P Yousuf S Ali Z Adhikari A Rasheed S Khan IA Ngadjui BT Fun HK Choudhary MI 《Organic letters》2011,13(20):5492-5495
Canarene (1), a triterpene with an unprecedented carbon backbone, was isolated from Canarium schweinfurthii . It is the first member of a new class of triterpenoids, for which the name "canarane' is proposed. 1 showed weak α-glucosidase inhibitory activity, and its structure was unambiguously deduced by single-crystal X-ray diffraction. 相似文献
987.
CuO nanocrystalline powder has been synthesized by a sol?gel auto combustion route with cetyltrimethylammonium bromide (CTAB) as cationic surfactant, and sodium dodecyl sulphate (SDS) as anionic surfactant. The powder samples are characterized by TGA/DTA, XRD, FESEM, and TEM techniques. Thermal analysis of the dried gel samples shows that addition of surfactant in the precursor increases the heat of reaction, which is evolved in the decomposition of metal citrate complex. The CTAB and SDS addition in the reaction mixture lowers the average crystallite size to few tens of nanometer. Surfactant doping in precursor causes a variation in lattice strain and changes to its type to compressive. CuO nanoparticles are bound together into facets–like weakly aggregated clusters, as indicated by FESEM images. TEM micrographs indicate the porous, nearly spherical particles having crystallite size around 7 and 18 nm for CTAB and SDS surfactant assisted CuO samples respectively. CuO nanoparticles assembled as thick film have been tested for their response to 100 ppm ammonia gas at room temperature. Cationic surfactant assisted sample shows maximum response to ammonia as compared to anionic surfactant. The CTAB assisted sensor shows almost completes recovery in 500 s whereas SDS assisted sample shows 75% recovery in the same time. The ammonia response of the films obeys the Elovich equation. The response rate of sensor is found to be maximum for CTAB assisted CuO films as compared to other samples. The kinetics of the response reaction shows that the ionic surfactants assisted CuO follows second order reaction kinetics. 相似文献
988.
In this work, we introduce a two-dimensional domain predator-prey model with strong Allee effect and investigate the Turing instability and the phenomena of the emergence of patterns. The occurrence of the Turing instability is ensured by the conditions that are procured by using the stability analysis of local equilibrium points. The amplitude equations (for supercritical case cubic Stuart–Landau equation and for subcritical quintic Stuart–Landau equation) are derived appropriate for each case by using the method of multiple time scale and show that the system supports patterns like squares, stripes, mixed-mode patterns, spots and hexagonal patterns. We obtain the asymptotic solutions to the model close to the onset instability based on the amplitude equations. Finally, numerically simulations tell how cross-diffusion plays an important role in the emergence of patterns. 相似文献
989.
Twenty acid chlorides, 4-(mono/di-benzyloxy)-4-ketobutanoyl chlorides (Ia–XXa) were synthesised by the reaction of monoesters of succinic acid with thionyl chloride. The product thus obtained (4-benzyloxy-4-ketobutanoyl chlorides) was treated with diethylcadmium to convert it into the corresponding keto-esters (Ib–XXb), the mono/di-benzyl-γ-ketohexanoates, with a good yield. All the compounds thus prepared were characterised by physical, spectroscopic (UV-VIS, IR, 1H NMR, 13C NMR), and mass measurements techniques. 相似文献
990.
Mohd. Naushad Alam Farhan Jalees Ahmad Zeenat Iqbal M. Aqil Aatif Ali 《Journal of Dispersion Science and Technology》2013,34(3):415-420
Amiloride hydrochloride, a generally used diuretic recently has been found effective in the treatment of epilepsy. The side effects of the drug, such as hyperkalemia, hypertension, and hyperaldosteronism were controlled by reducing the dose and targeting the drug to the brain. The objective of this study was to determine the factors influencing encapsulation of amiloride hydrochloride in liposomes and to demonstrate the anti‐epileptic potential of liposomal drug. A series of liposomal formulations of amiloride hydrochloride were prepared by varying the compositions of the formulations. The optimized formulation consisted of 10 mg/mL of amiloride hydrochloride, L‐phosphatidyl choline, lecithin, cholesterol, and butylated hydroxy toulene. The percentage entrapment efficiency in the optimized formulation was 44%. The drug to lipids ratio and L‐phosphatidyl choline: lecithin: cholesterol: butylated hydroxy toulene ratios were 2.0:3.0 and 5:5:5:2, respectively. The formulation showed an in vitro release of 98.17% in 8 hours, and the best fit kinetic model was Peppas model. Treatment with amiloride hydrochloride liposomes resulted in a significant increase in seizure threshold as compared to free drug in increasing current electroshock seizures in mice, which indicated an increase in CNS uptake of drug in liposome formulation. 相似文献