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151.
Aguilar-Moncayo M Takai T Higaki K Mena-Barragán T Hirano Y Yura K Li L Yu Y Ninomiya H García-Moreno MI Ishii S Sakakibara Y Ohno K Nanba E Ortiz Mellet C García Fernández JM Suzuki Y 《Chemical communications (Cambridge, England)》2012,48(52):6514-6516
Competitive inhibitors of either α-galactosidase (α-Gal) or β-galactosidase (β-Gal) with high affinity and selectivity have been accessed by exploiting aglycone interactions with conformationally locked sp(2)-iminosugars. Selected compounds were profiled as potent pharmacological chaperones for mutant lysosomal α- and β-Gal associated with Fabry disease and GM(1) gangliosidosis. 相似文献
152.
K Sakakibara LA Joyce T Mori T Fujisawa SH Shabbir JP Hill EV Anslyn K Ariga 《Angewandte Chemie (International ed. in English)》2012,51(38):9643-9646
Push a host: Mechanical compression was applied to a host monolayer at an interface, which facilitated an indicator displacement assay. The fluorescence resonance energy transfer (FRET) between the host and indicator was switched on by this compression. Addition of D-glucose caused the indicator to be displaced, effectively quenching the FRET process. 相似文献
153.
Kazunori Tsubaki Masahide Sakakibara Yuki Nakatani Takeo Kawabata 《Tetrahedron》2006,62(44):10321-10324
The efficient functionalization of three upper rims based on Suzuki-Miyaura coupling to temporarily lower rim-protected hexahomotrioxacalix[3]arenes was developed. After deprotection of the three protecting groups, the three upper rim-functionalized and lower rim-free hexahomotrioxacalix[3]arenes 5a-5m were synthesized. 相似文献
154.
Onimaru T Matsumoto KT Inoue YF Umeo K Sakakibara T Karaki Y Kubota M Takabatake T 《Physical review letters》2011,106(17):177001
An antiferroquadrupolar ordering at T(Q)=0.11 K has been found in a Pr-based superconductor PrIr(2)Zn(20). The measurements of specific heat and magnetization revealed the non-Kramers Γ(3) doublet ground state with the quadrupolar degrees of freedom. The specific heat exhibits a sharp peak at T(Q)=0.11 K. The increment of T(Q) in magnetic fields and the anisotropic B-T phase diagram are consistent with the antiferroquadrupolar ordered state below T(Q). The entropy release at T(Q) is only 20% of Rln2, suggesting that the quadrupolar fluctuations play a role in the formation of the superconducting pairs below T(c)=0.05 K. 相似文献
155.
Dr. Tsubasa Inokuma Takuya Sakakibara Takatoshi Someno Kana Masui Dr. Akira Shigenaga Prof. Dr. Akira Otaka Prof. Dr. Ken-ichi Yamada 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(60):13829-13832
A practical method for synthesizing chiral α-amino phosphonic acid derivatives was developed. Readily available and stable N-o-nitrophenylsulfenyl (Nps) imino phosphonate was utilized as a substrate for a highly enantioselective Friedel–Crafts-type addition of indole or pyrrole nucleophiles catalyzed by chiral phosphoric acid. The resulting adduct was easily converted into N-9-fluorenylmethyloxycarbonyl (Fmoc) amino phosphonic acid, which is useful for synthesizing peptides containing an amino phosphonic acid. 相似文献
156.
Millioni R Miuzzo M Puricelli L Iori E Sbrignadello S Dosselli R Cecconi D Tessari P Righetti PG 《Electrophoresis》2010,31(23-24):3863-3866
Novel instrumentation for performing large-size (>25 cm) 2-D maps is reported here. To perform the first dimension, we developed a power supply that can deliver a voltage of up to 15,000 V and allows regulation of current (up to 200 μA) onto each individual focusing IPG strip. The IEF strip tray can accommodate up to 12 IPG strips and the electrodes slide on a ruler, thus permitting running strips of any length up to 45 cm. In addition, this apparatus also includes a second power supply that allows the performance of electrophoresis at high amperage (400 mA) and a Peltier system that allows a 10-80°C temperature control. 相似文献
157.
158.
Skeletal muscle atrophy is the decrease in muscle mass and strength caused by reduced protein synthesis/accelerated protein degradation. Various conditions, such as denervation, disuse, aging, chronic diseases, heart disease, obstructive lung disease, diabetes, renal failure, AIDS, sepsis, cancer, and steroidal medications, can cause muscle atrophy. Mechanistically, inflammation, oxidative stress, and mitochondrial dysfunction are among the major contributors to muscle atrophy, by modulating signaling pathways that regulate muscle homeostasis. To prevent muscle catabolism and enhance muscle anabolism, several natural and synthetic compounds have been investigated. Recently, polyphenols (i.e., natural phytochemicals) have received extensive attention regarding their effect on muscle atrophy because of their potent antioxidant and anti-inflammatory properties. Numerous in vitro and in vivo studies have reported polyphenols as strongly effective bioactive molecules that attenuate muscle atrophy and enhance muscle health. This review describes polyphenols as promising bioactive molecules that impede muscle atrophy induced by various proatrophic factors. The effects of each class/subclass of polyphenolic compounds regarding protection against the muscle disorders induced by various pathological/physiological factors are summarized in tabular form and discussed. Although considerable variations in antiatrophic potencies and mechanisms were observed among structurally diverse polyphenolic compounds, they are vital factors to be considered in muscle atrophy prevention strategies. 相似文献
159.
160.
J. Happel S. Umemura Y. Sakakibara H. Blanck und S. Kunichika 《Colloid and polymer science》1977,255(5):513
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