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81.
Sandu Ion Dumitrache Florian Fleaca Claudiu Cretu Ovidiu Morjan Ion 《Solid State Sciences》2009,11(10):1793-1796
In this work we report the synthesis of free-standing films of polymer/nanocarbon composites. The method consists in forming a thin film of carbon nanoparticles onto the water's surface. Through the free infiltration of the polymer between the nanoparticles which form the film, after the polymer is cured, we obtain free-standing films of polymer/nanocarbon composites. The composite films are homogeneous; they have 5 wt.% carbon nanoparticles within the polymer matrix and are a few micrometers in thickness. 相似文献
82.
Aristidis E. Niotis Christos Mastichiadis Panagiota S. Petrou Ion Christofidis Athanasia Siafaka-Kapadai Konstantinos Misiakos Sotirios E. Kakabakos 《Analytical and bioanalytical chemistry》2009,393(3):1081-1086
An optical capillary waveguide fluoroimmunosensor based on glass capillaries internally coated with an ultrathin poly(dimethylsiloxane)
(PDMS) film is presented. The evaluation of the capillaries developed was done in comparison with aminosilanized [3-(aminopropyl)triethoxysilane,
APTES] glass and poly(methylpentene) (PMP) capillaries by immobilizing rabbit γ-globulins on the internal capillary wall.
Following reaction with (R)-phycoerythrin-labelled antibody, the capillary was scanned with a laser beam and the fluorescence waveguided through the
capillary wall was detected by a photomultiplier placed at one of its ends. The capillaries developed provided considerably
improved protein coating homogeneity (intracapillary coefficients of variation 2.9–6.6%) and repeatability (intercapillary
coefficients of variation 2.1–5.0%) compared with APTES-treated ones (7.9–13.4 and 8.5–15.2%, respectively). With use of these
capillaries in a sandwich-type immunosensor for the determination of rabbit γ-globulins, the assay detection limit was improved
eightfold (4.4 ng/mL) compared with that obtained using PMP capillaries (35.3 ng/mL), whereas the assay repeatability was
improved threefold (intra-assay coefficients of variation 5.9–13.1%) compared with APTES-treated capillaries (15.6–36%).
Optoelectronic set-up used to scan the capillaries (left) and representative fluorescence scannings of dual-band poly(methylpentene)
(PMP), PDMS-modified glass and APTES treated glass capillaries 相似文献
83.
Herein, we report the study of the three-photon absorption cross-section dependence on solvents parameters for a highly conjugated organic dye, 2,2'-(4,4'-(1E,1'E)-2,2'-(9,9-didecyl-9H-fluorene-2,7-diyl) bis(ethene-2,1-diyl)bis(4,1-phenylene))dibenzo[d]thiazole (A-pi-pi-pi-A). The three-photon absorption cross-section was measured for this organic dye in solution in four different solvents with polarity function, Deltaf between 0.162 and 0.247. The experiments show how the solvent's reorientation of the electrons and polarity contribute to the 3PA cross-section. Multiphoton-absorption experiments of A-pi-pi-pi-A in all four different solvents were performed with a tunable OPG pumped by a 25 picosecond Nd-YAG laser. 相似文献
84.
Cohanoschi I Belfield KD Toro C Yao S Hernández FE 《The Journal of chemical physics》2006,124(19):194707
The three-photon absorption cross sections of three different fluorene derivatives, with extended pi-electron conjugation lengths was experimentally measured and compared with shorter pi-electron conjugation length analogs. The effect of the conjugation length on the three-photon absorption cross section sigma(3) (') of this family of molecules has been elucidated. It is demonstrated that sigma(3) (') of the asymmetric compound D-pi-pi-pi-A is 6.6 times larger than its shorter configuration D-pi-A, while for the symmetric compounds D-pi-pi-pi-D and A-pi-pi-pi-A a two-fold enhancement was found relative to their shorter conjugation length analogs. Measurements of the three-photon excitation of these compounds in THF solution (10(-3)M) were accomplished with a tunable optical pulse generation pumped by a 25 ps Nd-YAG laser. 相似文献
85.
Magdalena Lungu Ştefania Gavriliu Elena Enescu Ioana Ion Alexandra Brătulescu Grigore Mihăescu Luminiţa Măruţescu Mariana Carmen Chifiriuc 《Journal of nanoparticle research》2014,16(1):1-15
Recent studies have revealed the existence of liver cancer stem cells (CSCs). Therefore, there is an urgent need for new and effective treatment strategies specific to liver CSCs. In this work, the poly(d,l-lactide-coglycolide) nanoparticles containing paclitaxel were prepared by emulsification-solvent evaporation method. The nanoparticles decorated with anti-CD133 antibody, termed targeted nanoparticles, were prepared by carbodiimide chemistry for liver CSCs. The physicochemical characteristics of the nanoparticles (i.e., encapsulation efficiency, particle size distribution, morphology, and in vitro release) were investigated. Cellular uptake and accumulation in tumor tissue of nanoparticles were observed. To assess anti-tumor activity of nanoparticles in vitro and in vivo, cell survival assay and tumor regression study were carried out using liver cancer cell lines (Huh7 and HepG2) and their xenografts. Particle size of targeted nanoparticles was 429.26 ± 41.53 nm with zeta potential of ?11.2 mV. Targeted nanoparticles possessed spherical morphology and high encapsulation efficiency (87.53 ± 5.9 %). The accumulation of targeted nanoparticles depends on dual effects of passive and active targeting. Drug-loaded nanoparticles showed cytotoxicity on the tumor cells in vitro and in vivo. Targeted nanoparticles resulted in significant improvement in therapeutic response through selectively eliminating CD133 positive subpopulation. These results suggested that the novel nanoparticles could be a promising candidate with excellent therapeutic efficacy for targeting liver CSCs. 相似文献
86.
O'Reilly ME Ghiviriga I Abboud KA Veige AS 《Journal of the American Chemical Society》2012,134(27):11185-11195
Appending an amine to a C═C double bond drastically increases the nucleophilicity of the β-carbon atom of the alkene to form an enamine. In this report, we present the synthesis and characterization of a novel CF(3)-ONO(3-) trianionic pincer-type ligand, rationally designed to mimic enamines within a metal coordination sphere. Presented is a synthetic strategy to create enhanced nucleophilic tungsten-alkylidene and -alkylidyne complexes. Specifically, we present the synthesis and characterization of the new CF(3)-ONO(3-) trianionic pincer tungsten-alkylidene [CF(3)-ONO]W═CH(Et)(O(t)Bu) (2) and -alkylidyne {MePPh(3)}{[CF(3)-ONO]W≡C(Et)(O(t)Bu)} (3) complexes. Characterization involves a combination of multinuclear NMR spectroscopy, combustion analysis, DFT computations, and single crystal X-ray analysis for complexes 2 and 3. Exhibiting unique nucleophilic reactivity, 3 reacts with MeOTf to yield [CF(3)-ONO]W═C(Me)(Et)(O(t)Bu) (4), but the bulkier Me(3)SiOTf silylates the tert-butoxide, which subsequently undergoes isobutylene expulsion to form [CF(3)-ONO]W═CH(Et)(OSiMe(3)) (5). A DFT calculation performed on a model complex of 3, namely, [CF(3)-ONO]W≡C(Et)(O(t)Bu) (3'), reveals the amide participates in an enamine-type bonding combination. For complex 2, the Lewis acids MeOTf, Me(3)SiOTf, and B(C(6)F(5))(3) catalyze isobutylene expulsion to yield the tungsten-oxo complex [CF(3)-ONO]W(O)((n)Pr) (6). 相似文献
87.
We consider a generalized model of repeated quantum interactions, where a system ${\mathcal{H}}$ is interacting in a random way with a sequence of independent quantum systems ${\mathcal{K}_n, n \geq 1}$ . Two types of randomness are studied in detail. One is provided by considering Haar-distributed unitaries to describe each interaction between ${\mathcal{H}}$ and ${\mathcal{K}_n}$ . The other involves random quantum states describing each copy ${\mathcal{K}_n}$ . In the limit of a large number of interactions, we present convergence results for the asymptotic state of ${\mathcal{H}}$ . This is achieved by studying spectral properties of (random) quantum channels which guarantee the existence of unique invariant states. Finally this allows to introduce a new physically motivated ensemble of random density matrices called the asymptotic induced ensemble. 相似文献
88.
A functionally enriched ABCD ring system of podophyllotoxin was generated through Pd(II)-templated cyclization of an alkynoic alkene, prepared in five steps from commercially available 6-bromopiperonal. This research expands upon the recent carboesterification methodology of Dong et al. (Angew. Chem., Int. Ed. 2009, 48, 9690–9692) by the application of PdCl2(MeCN)2, LiCl, and CuCl2 conditions, which yielded the desired podophyllotoxin scaffold with an embedded vinyl chloride moiety. Likewise, these conditions were successfully applied to a propargylic alkene prepared in three steps from 6-bromopiperonal. The resulting product contains the ABCD ring system of podophyllotoxin, but substitutes a D-ring furan for the D-ring lactone. Application of the recent methodology of Lu et al. (J. Org. Chem. 1995, 60, 1160–1169) on a related 1,6-enyne substrate led to functionalized α-methylene γ-butyrolactones instead (Pd2(dba)3·CHCl3, LiBr, and CuBr2). The latter conditions applied to an alkynoic alkene afforded the ABCD ring system of podophyllotoxin with a vinyl bromide group. These vinyl halides allow for derivatization at a critical juncture in order to access novel podophyllotoxin analogs. 相似文献
89.
This work describes the attachment of two amino acid derivatives by olefin cross-metathesis using Grubbs' second generation catalyst. They were connected at the carboxyl termini. In addition, a cyclic dilactam scaffold was used, which reacted with only a fraction of the amino acid derivatives. The remaining fraction coupled directly coupled with no scaffold. This highly trans-selective double attachment resulted in the cross-metathesis of a variety of amino acids in a single reaction. 相似文献
90.
采用相对论和非相对论理论模型可描述奇异核的性质 .相对论平均场理论预言了2 6,2 7,2 8P存在一个质子晕 ,而27,28,29S存在两个质子晕 .最近 ,MSU的最新的实验发现了2 6,2 7,2 8P核存在一个质子晕.采用相对论 Hartree- Fock理论研究了 Fock项和矢量介子对奇异核性质的贡献,研究表明交换项和矢量介子对非常丰中子核性质的影响非常不同于对稳定线附近核性质的影响.同时,采用形变的Hartree- Fock- Bogoliubov理论研究了某些轻核同位素链的性质和形变. 相似文献