CaL-B a highly selective biocatalyst for the kinetic resolution of furylbenzthiazole-2-yl-ethanols and acetates

A highly stereoselective enzymatic kinetic resolution of novel various substituted racemic furylbenzthiazole-2-yl-ethanols and their acetates has been developed. Both processes, the enzymatic acylation of the racemic alcohols and the enzymatic methanolysis of racemic acetates yielded highly enantiomerically enriched (ee >98%) resolution product, when CaL-B was used as a biocatalyst in acetonitrile. The absolute configuration of the obtained (R)-(+)-1-(5-(4-chlorobenzo[d]thiazol-2-yl)furan-2-yl)ethanol was determined by a detailed ¹H NMR study of rac- and (+)-1-(5-(4-chlorobenzo[d]thiazol-2-yl)furan-2-yl)ethanol Mosher derivatives.     

Synthesis and Antimicrobial Evaluation of Some New 4,5′‐Bisthiazoles

Thiazole and bisthiazole derivatives represent a prevalent scaffold in the antimicrobial drug discovery. Therefore, we have decided to synthesize some new series of 4,5′‐bisthiazoles. A total of 17 compounds were synthesized, their structural elucidation being based on elemental analysis (C,H,N,S) and spectroscopic data (MS and ¹H NMR). Their in vitro antimicrobial activities were assessed against several Gram‐positive and Gram‐negative bacteria strains and also against one fungal strain (Candida albicans) using the difusimetric method. Some of the compounds showed modest to good antibacterial activity against Gram‐negative Escherichia coli and Salmonella typhimurium and Gram‐positive Staphylococcus aureus and Bacillus cereus bacterial strains. All of the synthesized compounds showed moderate to very good antifungal activity against C. albicans.     

Antioxidant activity of rosemary extracts in solution and embedded in polymeric systems

The rosemary extract was encapsulated in polyethylene or in covalently-based network gels. The covalent gels were obtained by the reaction of isocyanate end-capped polyethylene glycol (PEG) with β-cyclodextrin or glycerol. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay was used to evaluate the antioxidant activity (AA) of rosemary extract entrapped in polymeric structures and in ethanol or water solutions. The AA of the rosemary extract was determined using a DPPH radical for samples prepared in ethanol, and a water-soluble derivative, the sulphonated DPPH radical (DPPH-SO₃Na), for the rosemary extract in water. Formulation of the rosemary extract in polymeric gels ensures a rapid release which determines the AA values similar to those in solution.     

Separation of nitrophenols. Equilibriums in bi- and tri-phasic systems

The paper presents experimental data obtained in the study of liquid–liquid partition equilibriums in biphasic system in order to optimize the process of transport through bulk liquid membranes (triphasic partition systems). The partition equilibriums of some nitrophenols using chloroform as extraction solvent and membranary solvent, respectively, were studied. The influence of the pH on the partition equilibriums was investigated. The repartition constants and the pK_a values of the studied nitrophenols were calculated. Nitrophenols were transferred in triphasic system from a feed phase with pH 2, through a chloroform liquid membrane, into a receiving phase with pH 12, with efficiencies over 90%.     

Surface Analysis of Inhibitor Film Formed by 4-Amino-N-(1,3-thiazol-2-yl) Benzene Sulfonamide on Carbon Steel Surface in Acidic Media

Inhibitive properties of the antibacterial sulfa drug sulfathiazole—IUPAC name being 4-amino-N-(1,3-thiazol-2-yl) benzene sulfonamide—on the corrosion of carbon steel in 1.0 M HCl solution were investigated using weight loss measurements, electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). Sulfathiazole is a good adsorption inhibitor, and the inhibition efficiency increases with increasing concentration. Adsorption is spontaneous and is best described by Temkin isotherm. XPS analysis showed, at this stage, that the main product of corrosion is a nonstoichiometric Fe³⁺ oxide/oxyhydroxide consisting of a mixture of Fe₂O₃, α, and γ-FeO(OH) and/or Fe(OH)₃, where α, γ-FeO(OH) is the main phase.     

Some abstract maximal ideal-like spaces

Presented by R. S. Pierce.     

Sur les solutions fondamentales d'ordre fini de croissance

Sans résumé     

Rational ligand design for metal ion recognition. Synthesis of a N-benzylated N2S3-donor macrocycle for enhanced silver(I) discrimination

Four previously documented ligand design strategies for achieving Ag(I) discrimination have been applied to the design of a new N-benzylated N2S3-donor macrocycle; the latter shows high selectivity for Ag(I) over Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Pb(II) in log K and bulk membrane transport studies.     

Application of phase correlation to the montage synthesis and three-dimensional reconstruction of large tissue volumes from confocal laser scanning microscopy.

We have implemented and tested a new automatic method for the montage synthesis and three-dimensional (3D) reconstruction of large tissue volumes from confocal laser scanning microscopy data (CLSM). This method relies on maximization of the phase correlation between adjacent images. It was tested on a large specimen (a murine heart) that was cut into a number of individual sections with thickness appropriate for CLSM. The sections were scanned horizontally (in-plane) and vertically (perpendicular to the optical planes) to produce "tiles" of a 3D volume. Phase correlation maximization was applied to the montage synthesis of in-plane tiles and 3D alignment of optical slices within a given physical section. The performance of the new method is evaluated.     

Food web model with detritus path

We present and study a lattice (Monte Carlo) model of a food web consisting of three levels. Agents on the lowest level produce food from dead agents (detritus) of the upper levels and are themselves eaten by the first level species, which in turn are prey for the top level species. Agents which do not find food in a given time, die with a given probability, while eating enables them to produce offspring in their neighborhood. This rule applies to species on all levels, including the lowest one. The dynamics is therefore nutrient limited. We are considering two pathways — grazers and detritus (using dead organic matter). We show that the emerging dynamics is more complex than the ordinary predator-prey systems in which bottom species are indestructible. We investigate the viability of our model and we construct appropriate (extinct-alive) phase diagrams. We demonstrate how the temporal fluctuations in the densities of the three populations are correlated. We show also that the density of the middle level agents plays the key role in the viability of the investigated food web.