A Turn-on and Reversible Fluorescence Sensor for Zinc Ion Based on 4,5-Diazafluorene Schiff Base

A new 4,5-diazafluorene-based fluorescent chemosensor has been synthesized by Schiff base condensation of 9,9-bis(3,5-dimethyl-4-aminophenyl)-4,5-diazafluorene with salicylaldehyde. The interaction of Schiff base with different metal ions has been studied over photofluorescent spectra. The results showed that Schiff base exhibited 194-fold enhancements in fluorescence at 465 nm after Zn²⁺ ions. Such fluorescent responses could be detected by naked eye under UV-lamp. The complex solution (L-Zn²⁺) exhibited reversibility with EDTA.     

Inequalities for Purity Parameters of Multiqudit and Single-Qudit States

We analyze the recently found inequality for eigenvalues of the density matrix and purity parameters describing either a bipartite-system state or a single-qudit state. We rewrite the Minkowski-type trace inequality for the density matrices of the qudit states in terms of the purity parameters and discuss the properties of the inequality obtained, paying special attention to the X-states of two qubits and a single qudit. Also we study the relation of the purity inequalities obtained with the entanglement.     

6.1 MW, 10 kHz Side-Pumped Burst-Mode Nd:YAG Laser

We present a compact high-peak-power, high-repetition-rate burst-mode laser from a master-oscillator power amplifier (MOPA) at 1064 nm for laser-based measurement applications. The oscillator is an 808 nm pulsed laser diode side-pumped acousto-optical (A-O) Q-switched Nd:YAG laser at repetition rates ranging from 10–100 kHz, producing a pulse train with a pulse number of 2–25. The maximum output energy of the oscillator is 15.6 mJ at 10 kHz, whereas it is 1.7 mJ at 100 kHz. After twostage amplifiers, a single-pulse energy of 85.2 mJ with a pulse-width of 14.5 ns is achieved at 10 kHz, which produces a peak power of 6.1 MW. At 100 kHz, the total burst energy reaches 220 mJ with a single-pulse energy of 8.8 mJ in the pulse burst laser system.     

On Nonlocality of Quantum Objects

We present an option of the experiment with a correlated pair of particles in the entangled state, which provides the effect of a change in the polarization for entangled photons, and demonstrate the reality of all different superposition states and the corresponding vector of the quantum system state; also we analyze possible consequences of this fact. We propose a quantum realism paradigm within the relational paradigm instead of the local realism concept disproved by the experiments on verifying the Bell inequalities. We analyze the results of experimental research of the Leggett inequality violation with respect to the verification of the adequacy of different kinds of nonlocal hidden variable theories and suggest a new way of their evaluation based on the study of the photon cross-correlation suppression after a beam splitter and preparation of quantum squeezed states. We show that the interpretation based on the nonlocal hidden variable theory is inconsistent.     

High-throughput screening against $$\sim $$6.1 million structurally diverse,lead-like compounds to discover novel ROCK inhibitors for cerebral injury recovery

Rho-associated protein kinase (ROCK) has been recognized as an attractive therapeutic target to promote neurogenesis, neuroregeneration, and neurorecovery after cerebral injury. Here, a high-throughput screening protocol was described to discover novel ROCK inhibitors from a large chemical library containing \(\sim \)6.1 million structurally diverse, lead-like compounds. The protocol employed empirical rules such as ADMET evaluation and chemical similarity analysis to exclude those of drug-unlike candidates, and then molecular docking and binding affinity predictions were performed to suggest few promising candidates with high scores. Consequently, five compounds were successfully identified to have satisfactory activity profile with \(\hbox {IC}_{50}\) values at nanomolar level. In order to elucidate the molecular mechanism of inhibitor binding to target, the complex structures of ROCK kinase domain with the five identified compounds were modeled and examined in detail. A number of polar chemical forces such as hydrogen bonds and cation-\(\pi \) interactions as well as nonpolar contacts such as \(\pi \)–\(\pi \) stacking and hydrophobic forces were revealed at the complex interface, conferring high affinity and strong specificity to inhibitor binding. In addition, several key residues around the kinase active site, including Val90, Lys105, Asn203, and Phe368, were found to play an important role in binding.     

Cerium oxide-catalyzed multicomponent condensation approach to spirooxindoles in water

An efficient and facile green synthesis of spirooxindole derivatives bearing pyrano[2,3-c]pyrazole moiety has been achieved via a \(\mathrm{CeO}_{2}\)-NPs catalyzed four-component reaction in water. The protocol offers an environmentally benign and effective approach to highly functionalized and biologically interesting spiro[indoline-3,4\(^\prime \)-pyrano[2,3-c]pyrazole] derivatives. The synthesized compounds exhibit potent antioxidant and antibacterial activities.     

Influence of two different template removal methods on the micromorphology,crystal structure,and photocatalytic activity of hollow CdS nanospheres

Hollow cadmium sulfide (CdS) nanospheres of about 260 nm average diameters and about 30 nm shell thickness can be easily synthesized via a sonochemical process, in which polystyrene (PS) nanoparticles were employed as templates. In order to remove the PS templates, both etching and calcination were applied in this paper. The influence of the two different template removal methods on the surface micromorphology, crystal structure, and photocatalytic activity of hollow CdS nanospheres was carefully performed a comparative study. Results of X-ray diffraction, scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray, FT-IR, thermogravimetric analysis, Brunauer–Emmett–Teller, diffused reflectance spectra, and decolorization experiments showed that the different template removal methods exhibited a significant influence on the surface micromorphology, crystal structure, and photocatalytic activity of hollow CdS nanospheres. The CdS hollow nanospheres as-prepared by etching had pure cubic sphalerite structure, higher –OH content, less defects and exhibited good photocatalytic activity for rhodamine-B, Methylene Blue and methyl orange under UV–vis light irradiation. However, CdS hollow nanospheres obtained by calcination with a hexagonal crystal structure, less –OH content, more defects have shown worse photocatalytic activity. This indicated that surface micromorphology and crystalline phase were mainly factors influencing photocatalytic activity of hollow CdS nanospheres.     

Synthesis of selenium/EDTA-derived porous carbon composite as a Li–Se battery cathode

The carbon substrate with unique 3D macroporous structure has been prepared through the immediate carbonization of ethylenediaminetetraacetic acid (EDTA) and KOH mixture. The porous carbon composed of micro- and small mesoporous (2–5 nm) structure has a BET specific surface area of 1824.8 m² g^?1. The amorphous and nanosized Se is uniformly encapsulated into the porous structure of porous carbon using melting diffusion route, and the weight content of Se in target Se/C composite can be as high as ~50 %. As an Li–Se battery cathode, the Se/C composite delivers a reversible (2nd) discharge capacity of 597.4 mAh g^?1 at 0.24C and retains a discharge capacity of 538.4 mAh g^?1 at 0.24C after 100 cycles. Furthermore, the composite also has a stable capacity of 291.0 mAh g^?1 at a high current of 4.8C. The high specific area and good porous size of EDTA-derived carbon substrate may a be responsibility for the excellent electrochemical performances of Se/C composite.