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71.
Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module
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72.
This is the first report on the diastereoselective addition of carbon nucleophiles to vinyl sulfone-modified hex-5-enofuranosides. The stereoelectronic properties of the substituents at the C-3 position and their interactions with the incoming carbon nucleophiles control the diastereoselectivity of addition at the C-5 position, favoring the formation of l-ido derivatives as major products in most of the cases studied. This new concept of stereocontrolled carbon-carbon bond formation in vinyl sulfone-modified carbohydrates is general in nature. The novel chirons generated by this diversity-oriented synthetic method have been implemented in the preparation of a wide range of hexofuranosyl C-5 branched-chain sugars, bicyclic derivatives, chirally pure enals, and densely functionalized carbocycles. 相似文献
73.
Indrajit Paul Amit Ghosh Dr. Michael Bolte Prof. Michael Schmittel 《ChemistryOpen》2019,8(11):1355-1360
Remote control in an eight-component network commanded both the synthesis and shuttling of a [2]rotaxane via metal-ion translocation, the latter being easily monitored by distinct colorimetric and fluorimetric signals. Addition of zinc(II) ions to the red colored copper-ion relay station rapidly liberated copper(I) ions and afforded the corresponding zinc complex that was visualized by a bright sky blue fluorescence at 460 nm. In a mixture of all eight components of the network, the liberated copper(I) ions were translocated to a macrocycle that catalyzed formation of a rotaxane by a double-click reaction of acetylenic and diazide compounds. The shuttling frequency in the copper-loaded [2]rotaxane was determined to k298=30 kHz (ΔH≠=62.3±0.6 kJ mol−1, ΔS≠=50.1±5.1 J mol−1 K−1, ΔG≠298=47.4 kJ mol−1). Removal of zinc(II) ions from the mixture reversed the system back generating the metal-free rotaxane. Further alternate addition and removal of Zn2+ reversibly controlled the shuttling mode of the rotaxane in this eight-component network where the ion translocation status was monitored by the naked eye. 相似文献
74.
Soumitra Maity 《Tetrahedron》2009,65(45):9202-7242
A direct route for the synthesis of highly functionalized angularly substituted hydrindanes has been developed. The key step involves RO-RCM of an appropriately functionalized norbornene derivative. The hydrindane derivative obtained in this way has been used to accomplish a formal synthesis of bakkenolide-A. This protocol has also been extended for the synthesis of an advanced intermediate to the synthesis of the diterpene umbellactal. 相似文献
75.
A new ortho-phenylenediamine-based fluorescent cleft 1 has been designed and synthesized. The open cleft of 1 selectively recognizes tetrabutylammonium dihydrogen phosphate in CH3CN by exhibiting a significant decrease in the emission of anthracene. The interactions of 1 are also investigated in aq CH3OH where no measurable change in the emission is observed for tetrabutylammonium dihydrogen phosphate, although sodium salts of phosphate, hydrogen phosphate, and dihydrogen phosphate exhibit moderate changes. Tetrabutylammonium hydrogen sulfate is sensed effectively in aq CH3OH. The anion binding properties of 1 were evaluated by 1H NMR, UV-vis, and fluorescence spectroscopic methods. 相似文献
76.
Indrajit Bandyopadhyay Dr. Krishnan Raghavachari Prof. Amar H. Flood Prof. 《Chemphyschem》2009,10(14):2535-2540
The structures associated with halide (F?, Cl?, Br?) complexation inside CH hydrogen‐bonding macrocyclic receptors, called triazolophanes, are characterized using density functional theory (DFT). The associated binding energies in the gas and solution phases are evaluated. The ruffles in the empty triazolophane become smoothed‐out upon Cl?‐ and Br?‐ion binding directly into the middle of the cavity. The largely pre‐organized cavity morphs into an elliptical shape to facilitate shorter hydrogen bonds in the north and south regions and longer ones west and east. The smaller F? ion sits in, and flattens‐out, only the north (or south) region. The 1,2,3‐triazoles show shorter CH???Cl? contacts than for the phenylenes. Both Cl? and Br? show the same binding geometries but Cl? has a larger binding energy consistent with its stronger Lewis basicity. Model triads were used to decompose the overall binding energy into those of its components. In the course of this triad analysis, anion polarization was identified and its contribution to the triad???Cl? binding energy estimated. Consequently, the binding energies for the individual aryl units within the comparatively non‐polarized triazolophanes were estimated. The 1,2,3‐triazoles are twice as strong as the phenylenes thus contributing most of the interaction energy to Cl?‐ion binding. Therefore, the 1,2,3‐triazoles appear to approach the hydrogen bond strengths of the NH donors of pyrrole units. 相似文献
77.
We consider the limiting spectral distribution of matrices of the form \(\frac{1}{2b_{n}+1} (R + X)(R + X)^{*}\), where X is an \(n\times n\) band matrix of bandwidth \(b_{n}\) and R is a non random band matrix of bandwidth \(b_{n}\). We show that the Stieltjes transform of ESD of such matrices converges to the Stieltjes transform of a non-random measure. And the limiting Stieltjes transform satisfies an integral equation. For \(R=0\), the integral equation yields the Stieltjes transform of the Marchenko–Pastur law. 相似文献
78.
Akshita Khandelwal Danish Khan Jyoti Kuntail Indrajit Sinha 《International journal of quantum chemistry》2024,124(1):e27237
Reducing p-nitrophenol (PNP) to p-aminophenol is an industrially relevant synthesis. Nevertheless, only a few heterogeneous catalysts have been evaluated for the reduction of PNP by glycerol. Appropriate quantum computational studies can screen potential catalysts for this crucial green reaction. The present research investigates the catalytic activities of Pd@Ag and Ni@Ag core-shell nanogeometries toward PNP reduction by glycerol through density functional theory (DFT) calculations. The central atom of a geometry-optimized 13-atom Ag cluster was replaced by Pd and Ni atoms to create the core-shell morphologies. The interaction energies of PNP and glycerol with each of the (metal/bimetallic) clusters were evaluated by DFT calculations to find the best PNP and glycerol molecule orientation with the respective bimetallic cluster. Electrostatic potential surface and natural bond orbital analyses were performed to study the charge distribution and transfer between atomic orbitals. The frequencies of vibrational modes in isolated PNP/glycerol structures were compared to those when these molecules were in the presence of the different metal clusters to infer the effect of the interactions. All performed analyses indicated improved catalytic activity toward PNP reduction by glycerol upon Ni-doping of the Ag13 cluster. 相似文献
79.
A Das MR Molla B Maity D Koley S Ghosh 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(32):9849-9859
This paper reports comprehensive studies on the mixed assembly of bis-(trialkoxybenzamide)-functionalized dialkoxynaphthalene (DAN) donors and naphthalene-diimide (NDI) acceptors due the cooperative effects of hydrogen bonding, charge-transfer (CT) interactions, and solvophobic effects. A series of DAN as well as NDI building blocks have been examined (wherein the relative distance between the two amide groups in a particular chromophore is the variable structural parameter) to understand the structure-dependent variation in mode of supramolecular assembly and morphology (organogel, reverse vesicle, etc.) of the self-assembled material. Interestingly, it was observed that when the amide functionalities are introduced to enhance the self-assembly propensity, the mode of co-assembly among the DAN and NDI chromophores no longer remained trivial and was dictated by a relatively stronger hydrogen-bonding interaction instead of a weak CT interaction. Consequently, in a highly non-polar solvent like methylcyclohexane (MCH), although kinetically controlled CT-gelation was initially noticed, within a few hours the system sacrificed the CT-interaction and switched over to the more stable self-sorted gel to maximize the gain in enthalpy from the hydrogen-bonding interaction. In contrast, in a relatively less non-polar solvent such as tetrachloroethylene (TCE), in which the strength of hydrogen bonding is inherently weak, the contribution of the CT interaction also had to be accounted for along with hydrogen bonding leading to a stable CT-state in the gel or solution phase. The stability and morphology of the CT complex and rate of supramolecular switching (from CT to segregated state) were found to be greatly influenced by subtle structural variation of the building blocks, solvent polarity, and the DAN/NDI ratio. For example, in a given D-A pair, by introducing just one methylene unit in the spacer segment of either of the building blocks a complete change in the mode of co-assembly (CT state or segregated state) and the morphology (1D fiber to 2D reverse vesicle) was observed. The role of solvent polarity, structural variation, and D/A ratio on the nature of co-assembly, morphology, and the unprecedented supramolecular-switching phenomenon have been studied by detail spectroscopic and microscopic experiments in a gel as well as in the solution state and are well supported by DFT calculations. 相似文献
80.