Measurement and thermodynamic modeling of Np(V) solubility in aqueous K2CO3 solutions to high concentrations

The solubility of Np(V) solids was studied in 0.01 to 6.38 mol-Kg^-1 ₂CO₃ solutions. Two series of experiments were conducted from undersaturation using NpO₂OH(s) or KNpO₂CO₃(s) as the starting solid. The Np(V) solid phases observed at steady state are KNpO₂CO₃(s) and K₃NpO₂(CO₃)₂(s). The activity coefficient formalism of Pitzer was used to obtain a thermodynamic interpretation of these data, including the solubility constants: To model these data, we propose values for several binary and ternary ion interaction parameters among the carbonate ion, potassium ion, and the neptunyl triscarbonato ion. With these new parameters, the thermodynamic data base for Np(V) solubility in concentrated aqueous solutions has been extended to the NaK-C1-C1O₄-CO₃-H-OH-H₂O system.     

Development water in oil nanoemulsion of diethylcarbamazine for enhanced the characteristics for lymphatic targeting: A proof of concept study

As an antifilariasis drug, oral administration of diethylcarbamazine (DEC) could not effectively deliver the drug to the lymphatic system. Hydrophobic formulation with a particle size of <100 nm could improve the delivery of drug. Accordingly, we developed water in oil nanoemulsion encapsulating DEC. The nanoemulsion was less than 100 nm with negative charge, showing its suitability for lymphatic targeting. The nanoemulsion could sustain the release of DEC and improve the retention in intestinal tissue in comparison with DEC solution. Importantly, this approach did not cause any hemolysis in in vitro study and any irritation in in vivo study.     

Wavelet-type Transform and Bessel Potentials Associated with the Generalized Translation

Wavelet–type transform associated with singular Laplace–Bessel differential operator is introduced and the relevant Calderón–type reproducing formula is established. Representations of the generalized Bessel potentials 0)$ " align="middle" border="0"> and their inverses via the wavelet–type transform are obtained.     

Effect of contact stiffness modulation in contact-mode AFM under subharmonic excitation

We report on the effect of fast contact stiffness modulation on frequency response to 2:1 subharmonic resonance in contact-mode atomic force microscopy. The model of the contact-mode dynamic between the tip of the microbeam and the moving surface consists of a lumped single degree of freedom Hertzian contact oscillator. Perturbation methods are applied to obtain the frequency response of the slow dynamic of the system. We focus on the effect of the amplitude and the frequency of the modulation on the nonlinear characteristic of the contact stiffness, the jump phenomenon and the shift in the frequency response of the subharmonic. We also show the effect of the contact stiffness modulation on the interval of the unstable trivial solution which is directly correlated to the depth of the jump. The obtained results can directly influence the material properties and the loss of contact between the tip and the sample.     

Infinite independent sets in distributive lattices

We show that a poset P contains a subset isomorphic to if and only if the poset J(P) consisting of ideals of P contains a subset isomorphic to the power set of κ. If P is a join-semilattice this amounts to the fact that P contains an independent set of size κ. We show that if κ := ω and P is a distributive lattice, then this amounts to the fact that P contains either or as sublattices, where Γ and Δ are two special meet-semilattices already considered by J. D. Lawson, M. Mislove and H. A. Priestley.Dedicated to the memory of Ivan RivalReceived April 22, 2003; accepted in final form July 11, 2004.This revised version was published online in August 2005 with a corrected cover date.     

Generalized Assignment Type Goal Programming Problem: Application to Nurse Scheduling

The notion of the Generalized Assignment Type Goal Programming Problem is introduced to consider the additional side constraints of an Assignment Type problem as goal functions. A short term Tabu Search method together with diversification strategies are used to deal with this model. The methods are tested on real-world Nurse Scheduling Problems.     

Computational Study of Asian Propolis Compounds as Potential Anti-Type 2 Diabetes Mellitus Agents by Using Inverse Virtual Screening with the DIA-DB Web Server,Tanimoto Similarity Analysis,and Molecular Dynamic Simulation

Propolis contains a wide range of pharmacological activities because of their various bioactive compounds. The beneficial effect of propolis is interesting for treating type-2 diabetes mellitus (T2DM) owing to dysregulation of multiple metabolic processes. In this study, 275 of 658 Asian propolis compounds were evaluated as potential anti-T2DM agents using the DIA-DB web server towards 18 known anti-diabetes protein targets. More than 20% of all compounds could bind to more than five diabetes targets with high binding affinity (<−9.0 kcal/mol). Filtering with physicochemical and pharmacokinetic properties, including ADMET parameters, 12 compounds were identified as potential anti-T2DM with favorable ADMET properties. Six of those compounds, (2R)-7,4′-dihydroxy-5-methoxy-8-methylflavone; (RR)-(+)-3′-senecioylkhellactone; 2′,4′,6′-trihydroxy chalcone; alpinetin; pinobanksin-3-O-butyrate; and pinocembrin-5-methyl ether were first reported as anti-T2DM agents. We identified the significant T2DM targets of Asian propolis, namely retinol-binding protein-4 (RBP4) and aldose reductase (AKR1B1) that have important roles in insulin sensitivity and diabetes complication, respectively. Molecular dynamic simulations showed stable interaction of selected propolis compounds in the active site of RBP4 and AKR1B1. These findings suggest that Asian propolis compound may be effective for treatment of T2DM by targeting RBP4 and AKR1B1.     

Fruits Vinegar: Quality Characteristics,Phytochemistry, and Functionality

The popularity of fruits vinegar (FsV) has been increased recently as a healthy drink wealthy in bioactive compounds that provide several beneficial properties. This review was designed in the frame of valorization of fruits vinegar as a by-product with high value added by providing overall information on its biochemical constituents and beneficial potencies. It contains a cocktail of bioactive ingredients including polyphenolic acids, organic acids, tetramethylperazine, and melanoidins. Acetic acid is the most abundant organic acid and chlorogenic acid is the major phenol in apple vinegar. The administration of fruits vinegar could prevent diabetes, hypercholesterolemia, oxidative stress, cancer, and boost immunity as well as provide a remarkable antioxidant ability. The production techniques influence the quality of vinegar, and consequently, its health benefits.     

Phase equilibrium properties of binary aqueous solutions containing ethanediamine, 1,2-diaminopropane, 1,3-diaminopropane,or 1,4-diaminobutane at several temperatures

The vapour pressures of {ethanediamine (EDA) + water}, {1,2-diaminopropane (1,2-DAP) + water}, {1,3-diaminopropane (1,3-DAP) + water} or {1,4-diaminobutane (1,4-DAB) + water} binary mixtures, and of pure EDA, 1,2-DAP, 1,3-DAP, 1,4-DAB, and water components were measured by means of two static devices at temperatures between (293 and 363) K. The data were correlated with the Antoine equation. From these data, the excess Gibbs function (G^E) was calculated for several constant temperatures and fitted to a fourth-order Redlich–Kister equation using the Barker’s method. The {ethanediamine (EDA) + water}, and {1,2-diaminopropane (1,2-DAP) + water} binary systems show negative azeotropic behaviour. The aqueous solutions of EDA, 1,2-DAP, or 1,3-DAP exhibit negative deviations in G^E for all investigated temperatures over the whole composition range whereas the (1,4-DAB + water) binary mixture shows negative G^E for temperatures (293.15 < T/K < 353.15) and a sinusoidal shape for G^E at T = 363.15 K.     

Synthesis and Structural Characterization of Two New Layered Inorganic–Organic Hybrid Zinc Phosphites Templated by Cyclam: Zn(HPO3)2·0.5(C10H28N4) and Zn2(HPO3)3·0.5(C10H28N4)

Abstract  

Using 1,4,8,11-tetraazacyclotetradecane (cyclam) as a template, two new layered zincophosphites, Zn(HPO₃)₂·0.5(C₁₀H₂₈N₄) (1) and Zn₂(HPO₃)₃·0.5(C₁₀H₂₈N₄) (2), were synthesized and characterized by single crystal X-ray diffraction. The two new compounds crystallize in the triclinic system with the space group P − 1 and the cell parameters: a = 8.3130 ?, b = 8.7289 ?, c = 9.0055 ?, α = 106.90(1), β = 95.56(1), γ = 105.30(1), V = 592.31 ?³, Z = 2 for 1 and a = 9.0406 ?, b = 9.4234 ?, c = 9.4519 ?, α = 91.19(1), β = 100.73(1), γ = 106.85(1), V = 754.82 ?³, Z = 2 for 2. Both structures are described in terms of phosphometallic slabs hosting the cyclam cation.