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441.
Graziano Crasta Ilaria Fragalà Filippo Gazzola 《NoDEA : Nonlinear Differential Equations and Applications》2005,12(1):93-109
For a given p > 1 and an open bounded convex set
we consider the minimization problem for the functional
over
Since the energy of the unique minimizer up may not be computed explicitly, we restrict the minimization problem to the subspace of web functions, which depend only on the distance from the boundary δΩ. In this case, a representation formula for the unique minimizer vp is available. Hence the problem of estimating the error one makes when approximating Jp(up) by Jp(vp) arises. When Ω varies among convex bounded sets in the plane, we find an optimal estimate for such error, and we show that it is decreasing and infinitesimal with p. As p → ∞, we also prove that up − vp converges to zero in
for all m < ∞. These results reveal that the approximation of minima by means of web functions gains more and more precision as convexity in Jp increases. 相似文献
442.
The influence of superplasticizers on the first steps of tricalcium silicate hydration studied by NMR techniques 总被引:1,自引:0,他引:1
Pirazzoli I Alesiani M Capuani S Maraviglia B Giorgi R Ridi F Baglioni P 《Magnetic resonance imaging》2005,23(2):277-284
The influence of superplasticizer sulfonated naphthalene formaldehyde (SNF) on the hydration process of tricalcium silicate (C3S) paste was investigated by (1)H nuclear magnetic resonance spin-spin and spin lattice relaxation times. The addition of SNF superplasticizer to C3S paste clearly affects the morphology and growth rates of the hydration products, mainly by increasing the dormant period length, which lasts for several hours more than in conventional C3S hydrated paste, while reducing the acceleration period length. The relaxation data indicated that a pronounced delay occurs in the C3S hardening when sulfonated polymers are added to the makeup water. For all the analyzed samples, prepared with a water-to-C3S ratio of 0.4, the decay of the echo magnetization has been fitted by adopting both a monoexponential and a biexponential relaxation model in order to evaluate the contributions from water in different regimes of hydration. 相似文献
443.
Letizia Modeo Giovanna Rosati Ilaria Andreoli Simone Gabrielli Franco Verni Giulio Petroni 《Proceedings of the Japan Academy. Series B, Physical and biological sciences》2006,82(9):359-374
In the present paper we redescribe the ciliate Chattonidium setense Villeneuve 1937 combining morphological observations (live, stained, scanning, and transmission electron microscope) with behavioral notes and molecular data. Ultrastructural analysis revealed remarkable similarities between Chattonidium and representative members of the class Heterotrichea in cortical structure and cytoplasmic organization. The most similar genus for these aspects appears to be Condylostoma. To verify this relatedness, 18S rRNA genes from Chattonidium and from one Condylostoma species were sequenced. Phylogenetic analysis indicates Chattonidium belongs to the class Heterotrichea defined according to the modern taxonomy, and confirms its relatedness with Condylostoma already hypothesized by Villeneuve-Brachon (1940). The presence of the aboral cavity complex, a unique feature never described in other ciliates, and its peculiar organization revealed by ultrastructural analysis fully justify, in our opinion, the maintenance of Chattonidium in the separate family Chattonidiidae, established by Villeneuve-Brachon in 1940. 相似文献
444.
Francesca Picarazzi Ilaria Vicenti Francesco Saladini Maurizio Zazzi Mattia Mori 《Molecules (Basel, Switzerland)》2020,25(23)
The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral replication process, catalyzing the viral RNA synthesis using a metal ion-dependent mechanism. In recent years, RdRp has emerged as an optimal target for the development of antiviral drugs, as demonstrated by recent approvals of sofosbuvir and remdesivir against Hepatitis C virus (HCV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), respectively. In this work, we overview the main sequence and structural features of the RdRp of emerging RNA viruses such as Coronaviruses, Flaviviruses, and HCV, as well as inhibition strategies implemented so far. While analyzing the structural information available on the RdRp of emerging RNA viruses, we provide examples of success stories such as for HCV and SARS-CoV-2. In contrast, Flaviviruses’ story has raised attention about how the lack of structural details on catalytically-competent or ligand-bound RdRp strongly hampers the application of structure-based drug design, either in repurposing and conventional approaches. 相似文献
445.
Umberto Raucci Maria Gabriella Chiariello Federico Coppola Fulvio Perrella Marika Savarese Ilaria Ciofini Nadia Rega 《Journal of computational chemistry》2020,41(20):1835-1841
Electrons and protons are the main actors in play in proton coupled electron transfer (PCET) reactions, which are fundamental in many biological (i.e., photosynthesis and enzymatic reactions) and electrochemical processes. The mechanism, energetics and kinetics of PCET reactions are strongly controlled by the coupling between the transferred electrons and protons. Concerted PCET reactions are classified according to the electronical adiabaticity degree of the process. To discriminate among different mechanisms, we propose a new analysis based on the use of electron density based indexes. We choose, as test case, the 3-Methylphenoxyl/phenol system in two different conformations to show how the proposed analysis is a suitable tool to discriminate between the different degree of adiabaticity of PCET processes. The very low computational cost of this procedure is extremely promising to analyze and provide evidences of PCET mechanisms ruling the reactivity of many biological and catalytic systems. 相似文献
446.
Sushmitha Chandrabhas Dr. Subhabrata Maiti Dr. Ilaria Fortunati Prof. Dr. Camilla Ferrante Dr. Luca Gabrielli Prof. Dr. Leonard J. Prins 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(49):22407-22413
Nature adopts complex chemical networks to finely tune biochemical processes. Indeed, small biomolecules play a key role in regulating the flux of metabolic pathways. Chemistry, which was traditionally focused on reactions in simple mixtures, is dedicating increasing attention to the network reactivity of highly complex synthetic systems, able to display new kinetic phenomena. Herein, we show that the addition of monophosphate nucleosides to a mixture of amphiphiles and reagents leads to the selective templated formation of self-assembled structures, which can accelerate a reaction between two hydrophobic reactants. The correct matching between nucleotide and the amphiphile head group is fundamental for the selective formation of the assemblies and for the consequent up-regulation of the chemical reaction. Transient stability of the nanoreactors is obtained under dissipative conditions, driven by enzymatic dephosphorylation of the templating nucleotides. These results show that small molecules can play a key role in modulating network reactivity, by selectively templating self-assembled structures that are able to up-regulate chemical reaction pathways. 相似文献
447.
Botta B D'Acquarica I Monache GD Subissati D Uccello-Barretta G Mastrini M Nazzi S Speranza M 《The Journal of organic chemistry》2007,72(24):9283-9290
Four cone resorc[4]arene octamethyl ethers (10, 11, ent-10, and ent-11) tetrafunctionalized at the feet with valyl-leucine [LL- (6); DD- (ent-6)] and leucyl-valine [LL- (9); DD- (ent-9)] methyl esters have been synthesized. These compounds, obtained by conjugation of macrocycle tetracarboxylic acid chlorides with the appropriate terminal amino groups of the above dipeptides, are N-linked peptidoresorc[4]arenes. We found that these macrocycles (M) are capable of recognizing the homologue dipeptides as guests (G), both in solution and in the gas phase, by forming relatively stable host-guest complexes ([M.G]), resistant to chromatographic purification but not to heating. Complexation phenomena between M and G in solution were investigated by NMR methods, including NMR DOSY experiments, for the detection of translational diffusion. Heteroassociation constants of 2030 and 186 M(-1) were obtained by the Foster-Fyfe method for the complexes [10.6] and [10.ent-6], respectively, the latter being comparable to the self-association constant of dipeptide itself. Conversely, the structural features of the proton-bound complexes [M.H.Gn]+ (n = 1, 2), generated in the gas phase by electrospray ionization mass spectrometry (ESI-MS), were investigated by collision-induced dissociation (CID) experiments. In both cases, the four N-linked peptidoresorc[4]arenes were shown to act as synthetic receptors and to recognize the homologue dipeptide by means of hydrogen bonds. 相似文献
448.
For \(\Omega \) varying among open bounded sets in \(\mathbb R ^n\) , we consider shape functionals \(J (\Omega )\) defined as the infimum over a Sobolev space of an integral energy of the kind \(\int _\Omega [ f (\nabla u) + g (u) ]\) , under Dirichlet or Neumann conditions on \(\partial \Omega \) . Under fairly weak assumptions on the integrands \(f\) and \(g\) , we prove that, when a given domain \(\Omega \) is deformed into a one-parameter family of domains \(\Omega _\varepsilon \) through an initial velocity field \(V\in W ^ {1, \infty } (\mathbb R ^n, \mathbb R ^n)\) , the corresponding shape derivative of \(J\) at \(\Omega \) in the direction of \(V\) exists. Under some further regularity assumptions, we show that the shape derivative can be represented as a boundary integral depending linearly on the normal component of \(V\) on \(\partial \Omega \) . Our approach to obtain the shape derivative is new, and it is based on the joint use of Convex Analysis and Gamma-convergence techniques. It allows to deduce, as a companion result, optimality conditions in the form of conservation laws. 相似文献
449.
Vincenzo Siano Ilaria D’Auria Fabia Grisi Chiara Costabile Pasquale Longo 《Central European Journal of Chemistry》2011,9(4):605-609
Grubbs II generation catalyst (3), bearing a fluorinated imidazolinium ligand, was investigated in cross metathesis (CM), ring closing metathesis (RCM) and
ring opening polymerization metathesis (ROMP) for a variety of substrates. Kinetic studies showed reduced stability of the
catalyst in methylene chloride following the first 15 minutes of reaction preventing a higher efficiency despite the very
high activity. Beneficial solvent effects on the catalyst stability were observed by performing RCM in C6F6.
相似文献
450.