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91.
Shoichi Ikeda Gerald D. Fasman 《Journal of polymer science. Part A, Polymer chemistry》1970,8(4):991-1001
The absorption and fluorescence spectra of a detergent, polyoxyethylene octylphenyl ether, were measured in water at different concentrations. The absorption spectra had a peak at 275 mμ and a shoulder at 281 mμ. The spectra were independent of concentration below the critical micelle concentration, but the molar extinction coefficients of the peak and the shoulder increased with concentration above the critical micelle concentration. The critical micelle concentration value derived from the absorption data was in good agreement with those obtained by other methods. The fluorescence spectra of the detergent in water were independent of concentration in dilute solutions, if the intensities of the spectra were normalized at the peak at 302 mμ. At higher concentrations, a weak excimer band appeared at 345 mμ, whose intensity increased with concentration. The excimer band manifested itself at a concentration slightly lower than the critical micelle concentration. The main band decreased and the excimer band increased, as the temperature was raised. An excimer band was observed in the same region of the spectra for the pure detergent, either in the solid or liquid state. The equilibrium solid spectra exhibited a very strong excimer emission. It was concluded that the excimers were formed within micelles in the case of aqueous solutions. 相似文献
92.
H Ikeda Y Shimonishi M Ohmura K Kishimoto K Kosakai K Hamada H Ochi 《Radioisotopes》1990,39(11):487-492
Textural features for phantom images were extracted. Texture parameters which represent RI distribution--skew, energy, entropy and angular second moment were used. But, it was difficult to analyse the images using discriminant analysis for textural features, because textural features had statistical noise. Therefore fuzzy reasoning was adapted to analyse the images. Textural features for six kinds of images were showed using membership function. The possibility to the image was evaluated using the value of membership function on each images. Fuzzy reasoning could be done easily using max-min composition formula. The reasoning was found more suitable to analyse the images than discriminant analysis and will be considered useful for analysis of clinical scintigrams. 相似文献
93.
Takashi Kajiwara Kensuke Katagiri Shinya Takaishi Masahiro Yamashita Nobuhiko Iki 《化学:亚洲杂志》2006,1(3):349-351
A dodecaholmium wheel of [Ho12(L)6(mal)4(AcO)4(H2O)14] ( 1 ; mal=malonate) was synthesized by using p‐tert‐butylsulfonylcalix[4]arene (H4L) as a cluster‐forming ligand. The wheel consists of three fragments of mononuclear A3? ([Ho(L)(mal)(H2O)]3?), trinuclear B3? ([Ho(H2O)2(mal)(Ho(L)(AcO))2]3?), and C3+ ([Ho(H2O)2]3+), and an alternate arrangement of these fragments (A3?? C3+? B3?? C3+? A3?? C3+? B3?? C3+? ) results in a wheel structure. The longest and shortest diameters of the core were estimated to be 17.7562(16) and 13.6810(13) Å, respectively, and the saddle‐shaped molecule possesses a pocketlike cavity inside. 相似文献
94.
T Yotsuyanagi N Ohta T Futo S Ito D N Chen K Ikeda 《Chemical & pharmaceutical bulletin》1991,39(11):3003-3006
Irreversible bindings of cis-diamminedichloroplatinum(II) (cis-DDP) to human serum albumin (HSA) were investigated in a pH 7.4 buffer containing 0.1 M NaCl at various molar ratios (cis-DDP/HSA) up to 60 over a 14 d period (37 degrees C). The metal binding seemed to reach a plateau when incubated at less than 10 times excess of cis-DDP. As the molar ratio increased, the reaction rate was relatively fast within the first day, followed by a moderate increase in the metal binding. When incubated at 60 times excess of cis-DDP, the metal bound as much as 20 mol per mol of HSA in 14 d. Fluorescence quenching of the metal-bound protein suggested that the tryptophan residue was gradually exposed to a hydrophilic environment as the metal binding increased. Furthermore, cis-DDP cleaved disulfide bonds at the ratio of 1 mol of disulfide bond per 5.3 mol of the metal binding. It was therefore suggested that the metal binding also occurred at several sites other than the disulfide bond. Warfarin binding to the metal-bound protein, examined by fluorescence changes, also decreased with increasing metal binding or cleavage of the disulfide bonds. Thus, cis-DDP bound to multiple sites in addition to the lone sulfhydryl group (Cys-34), suggesting that massive conformational changes of the protein took place. 相似文献
95.
Yasumitsu Tamura Yasuyoshi Miki Yoshinori Nishikawa Masazumi Ikeda 《Journal of heterocyclic chemistry》1976,13(2):317-320
N-Aminophenanthridinium salt reacted with dimethyl acetylenedicarboxylate in the presence of potassium carbonate to give a 3,3a-dihydropyrazolo[1,5-f]phenanthridine but with mono-substituted acetylenes (ethyl propiolate and benzoylacetylene) it produced aromatized pyrazolo-[1,5-f]phenanthridines (XII and XIII). The reaction of the N-benzoylimine with di-substituted acetylenes (dimethyl acetylenedicarboxylate and methyl phenylpropiolate) and mono-substituted acetylenes (ethyl propiolate and benzoylacetylene) yielded 1,3a-dihydropyrazolo[1,5-f]phenanthridines and the aromatized products (XII and XIII), respectively. 相似文献
96.
Here, we report a diversity-oriented synthetic approach toward skeletally diverse, cyclized peptidomimetics with diverse appendages. Starting from α-(N-acylamino)amides with various appendages, 12 to 16-membered lactams with defined olefin geometry were synthesized by a common synthetic sequence. We also synthesized the macrocycle in a liquid phase directed toward a construction of the peptidomimetics library. 相似文献
97.
Hayami S Hashiguchi K Juhász G Ohba M Okawa H Maeda Y Kato K Osaka K Takata M Inoue K 《Inorganic chemistry》2004,43(14):4124-4126
Cobalt(II) compounds [Co(pyterpy)Cl(2)].MeOH (1.(MeOH)) and [Co(pyterpy)Cl(2)].2H(2)O (1.(2H(2)O)) were synthesized. The compound 1.(MeOH) forms the quasi 3-D networks by making pi-pi stacking between the 1-D chains. The methanol molecules from 1.(MeOH) can be removed by heating, and substituted by absorption of water molecules. The MeOH molecules in 1.(MeOH) are removed by heating at 410 K, and they are substituted by water molecules to form 1.(2H(2)O). 1.(2H(2)O) exhibits a S = (3)/(2) (HS) left arrow over right arrow S = (1)/(2) (LS) spin transition with a thermal hysteresis. We have succeeded in constructing a guest dependent 1-D spin-crossover cobalt(II) compound. 相似文献
98.
Human and avian influenza type A viruses bind sialylated pentasaccharides. Herein, the total synthesis of four of these glycans is reported. Efficient sialylations relied on two N‐Troc‐protected (Troc=2,2,2‐trichloroethoxycarbonyl) sialic acid building blocks. The first, a thiophenyl glycoside, readily produced the sialyl‐α(2‐6)galactose disaccharide. Combination of the second building block, a novel glycosyl phosphite, and a benzylidene‐protected galactoside produced the best results for the formation of the sialyl‐α(2‐3)galactose. Two common trisaccharides were assembled by the introduction of glucose, galactose, and glucosamine building blocks followed by selective deprotection. Two sets of pentasaccharides were obtained by the union of two sialylgalactose N‐phenyl trifluoroacetimidate building blocks with the two trisaccharides above. Global deprotection furnished the desired pentasaccharides. The products of these total syntheses are currently employed on the surface of carbohydrate microarrays to detect and type different strains of the influenza virus. 相似文献
99.
Takegawa Y Deguchi K Ito S Yoshioka S Nakagawa H Nishimura S 《Rapid communications in mass spectrometry : RCM》2005,19(7):937-946
To investigate the possibility of structural assignment based on negative-ion MS2 spectral matching, three isomeric pairs of 2-aminopyridine (PA)-derivatized non-fucosylated, fucosylated, and sialylated oligosaccharides (complex type N-glycans) were analyzed using high-performance liquid chromatography/ion trap mass spectrometry (HPLC/ITMS) with a sonic-spray ionization (SSI) source. In the SSI negative-ion mode the deprotonated molecule [M-2H]2- becomes prominent. Negative-ion MS2 spectra derived from such ions contain many fragment types (B and Y, C and Z, A, and D) and therefore are more informative than the positive-ion MS2 spectra derived from [M+H+Na]2+ ions, which usually consist mainly of B and Y fragment ions. In particular the internal ions (D- and E-type ions) provided useful information about the alpha1-6 branching patterns and the bisecting GlcNAc residue. Spectral matching based on the correlation coefficients between negative-ion MS2 spectra was performed in a manner similar to the positive-ion MS2 spectral matching previously reported. It was demonstrated that negative-ion MS2 spectral matching is as useful and applicable to the structural assignment of relatively large non-fucosylated, fucosylated, and sialylated PA-oligosaccharide isomers as its positive-ion counterpart. 相似文献
100.
Matsuura K Hibino M Ikeda T Yamada Y Kobayashi K 《Chemistry (Weinheim an der Bergstrasse, Germany)》2004,10(2):352-359
We describe herein the relationship between the spatial arrangement of self-organized galactose clusters and lectin recognition. beta-Galactose-modified deoxyuridine phosphoramidite was synthesized and applied to solid-phase synthesis to provide 18-, 20-, and 22-mers of site-specifically galactosylated oligodeoxynucleotides (Gal-ODNs). These Gal-ODNs were self-organized through hybridization with the corresponding 18-, 20-, and 22-mers of half-sliding complementary ODNs (hsc-ODNs) to give periodic galactoside clusters. The self-organization of ODNs was confirmed by size exclusion chromatography and gel electrophoresis. The binding of the Gal-clusters to the FITC-labeled RCA(120) lectin was analyzed by monitoring the change in fluorescence intensity. The assembly of 20-mer Gal-ODN with the 20-mer hsc-ODN was strongly and cooperatively recognized by the lectin. The 18-mer assembly was bound more weakly and less cooperatively, and the 22-mer assembly was minimally bound to the lectin. RCA(120) lectin recognized not only the density of galactoside residues, but also the spatial arrangement. The size of the Gal cluster was estimated from the association constant of Gal-ODN with hsc-ODN. The relationship between lectin-recognition and Gal-cluster size is also discussed. 相似文献