Lipase-catalyzed Irreversible Transesterification of Secondary Alcohols Using Isopropenyl Acetate

Summary. Asymmetric acetylation of a set of secondary alcohols with the innocuous acyl donor isopropenyl acetate catalyzed by a lipase from Pseudomonas cepacia immobilized on ceramic particles (PSL-C) in toluene as organic medium afforded the chiral alcohols and the corresponding acetates in high enantiomeric excess (up to 99%). An effective baseline separation of the enantiomers of both substrate and product was performed in one analysis without derivatization using gas chromatography on a new chiral stationary phase (CSP) Chirasil--Dex containing an undecamethylene spacer (C11-Chirasil-Dex).Received November 27, 2002; accepted (revised) January 9, 2003 Published online June 2, 2003     

Synthesis of substituted benz[<Emphasis Type="Italic">g</Emphasis>]indole-6,9-diones and benzo[<Emphasis Type="Italic">h</Emphasis>]quinoline-7,10-diones by heterocyclization of 6-alkynyl-5-amino-1,4-naphthoquinones

Substituted benz[g]indole-6,9-diones were synthesized by intramolecular cyclization of 6-alkynyl-5-amino-3-diethylamino-1,-4-naphthoquinones. A method was developed for the preparation of 2-aryl(or alkyl)-4,9-bis(dialkylamino)benzo[h]quinoline-7,10-diones, which involves the addition of a secondary amine to 6-acylethynyl-5-amino-3-diethylamino-1,-4-naphthoquinone followed by cyclization of the resulting adduct.__________Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 412–418, February, 2005.     

Substitution of acetylenic groups for halogen in the quinonoid ring

The bromine or iodine atom in the quinonoid ring devoid of +M substituent in the position neighboring to the halogen is replaced by acetylenic groups on treatment with Cu^I acetylides, prepared either beforehand or in situ, in a mixture of DMSO and CHCl₃ in the presence of a Pd complex catalyst. A series of mono- and diacetylenic derivatives of 1,4-naphtho- and 1,4-benzoquinone were prepared. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1636–1639, July, 2005.     

Reaction of 1-amino-2-phenylethynyl-and 2-acylethynyl-1-amino-9,10-anthraquinones with HNO2. Synthesis of 1H-3-acylnaphtho[2,3-g]indazole-6,11-diones

The reactions of 1-amino-2-phenylethynyl-and 2-acylethynyl-1-amino-9,10-anthraquinones with HNO₂ in a mixture of dioxane and a mineral acid at 20 °C were studied. Under these conditions, 2-alkynyl-1-amino-9,10-anthraquinones, irrespective of the structure of the C=CR substituent, are cyclized into 3-substituted 1H-naphtho[2,3-glindazole-6,11-diones. The nature of the acetylenic group in the initial compound and the choice of the mineral acid determine the structure of the substitutent in position 3 of the product (1,1-dichloroalkyl or acyl) but have no effect on the regiospecificity of cyclization. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 110–114, January, 1997.     

Wick Rotation for D-modules

We extend the classical Wick rotation to D-modules and higher codimensional submanifolds.     

Polar Symplectic Representations

We study polar representations in the sense of Dadok and Kac which are symplectic. We show that such representations are coisotropic and use this fact to give a classification. We also study their moment maps and prove that they separate closed orbits. Our work can also be seen as a specialization of some of the results of Knop on multiplicity free symplectic representations to the polar case.     

Polynomials in operator space theory: matrix ordering and algebraic aspects

We extend the \(\lambda \)-theory of operator spaces given in Defant and Wiesner (J. Funct. Anal. 266(9): 5493–5525, 2014), that generalizes the notion of the projective, Haagerup and Schur tensor norm for operator spaces to matrix ordered spaces and Banach \(*\)-algebras. Given matrix regular operator spaces and operator systems, we introduce cones related to \(\lambda \) for the algebraic operator space tensor product that respect the matricial structure of matrix regular operator spaces and operator systems, respectively. The ideal structure of \(\lambda \)-tensor product of \(C^*\)-algebras has also been discussed.