Resveratrol (3,4’,5-trihydroxystilbene) is beneficial to human health due to its diverse biological activities including its anti-inflammatory and anti-oxidative effects as confirmed by pharmacokinetic tests. Despite these clinical merits, resveratrol's limited hydrosolubility and chemical vulnerability remain challenging with regard to developing a controlled delivery system with enhanced bioavailability. In this work, we report a resveratrol-β-lactoglobulin (R-BLG) composite nanocoating through a layer-by-layer assembly with Fe(III)-tannic acid nanofilms. The R-BLG composite nanocoating can be formed in planar and particulate substrates, showing excellent film stability under a broad range of pH values and against enzymatic digestion during a weeklong incubation. We envision that the proteinaceous nanocoating herein could be combined with existing pharmaceutical carrier materials (e. g., microcapsules and nanoparticles) to realize advanced drug delivery systems with an expanded repertoire of hydrophobic drugs. 相似文献
Herein, we report the synthesis, and photochemical and -physical properties, as well as the catalytic performance, of a series of heteroleptic IrIII photosensitizers (IrPSs), [Ir(C^N)2(N^NAryl)]+, possessing ancillary ligands that are varied with aryl-substituents on bipyridyl unit [C^N=(2-pyridyl)benzo[b]thiophen-3-yl (btp); N^NAryl=4,4′-Y2-bpy (Y=−Ph or −PhSi(Ph)3]. We found that the π-extension of bipyridyl ligand by aryl-substitution put bipyridyl ligand in use as an electron relay unit that performed charge accumulation before delivering to the catalytic center, greatly improving the overall CO2-to-CO conversion activities. In a typical run, the aryl-substituted IrPS ( t Bu IrP-PhSi )-sensitized homogeneous systems (IrPS+ReI catalyst) gave a turnover number of 1340 (ΦCO=24.2 %) at the early stage of photolysis (<5 h). This study demonstrates that the π-character modulation on the ancillary bipyridyl ligand is critical for forthcoming catalytic performance. 相似文献
Journal of Thermal Analysis and Calorimetry - In the original publication of the article, Figs. 6 and 7 were published incorrectly without test fuel D80/nb20+BG (0.5 kg/h). 相似文献
The process characteristics of a new solid–liquid Cs+ separation from the radioactive liquid waste using a crown ether dicyclohexano-18-crown-6 as an extractant and an ionic liquid of 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide were studied. The physicochemical properties of the precipitate containing Cs+ which is an solid–liquid extraction product were investigated to identify the solid–liquid phase separability and Cs+ loading. The Cs+ separation process performances were compared experimentally with those of the conventional adsorption system for pretreatment requirement and the amount of Cs+ waste. It was observed that the solid–liquid separation method using ILs has high Cs+ separation performance especially in the low Cs+ concentration.
In this article, we consider the estimation problem of a tree model for multiple conditional quantile functions of the response. Using the generalized, unbiased interaction detection and estimation algorithm, the quantile regression tree (QRT) method has been developed to construct a tree model for an individual quantile function. However, QRT produces different tree models across quantile levels because it estimates several QRT models separately. Furthermore, the estimated quantile functions from QRT often cross each other and consequently violate the basic properties of quantiles. This undesirable phenomenon reduces prediction accuracy and makes it difficult to interpret the resulting tree models. To overcome such limitations, we propose the unified noncrossing multiple quantile regressions tree (UNQRT) method, which constructs a common tree structure across all interesting quantile levels for better data visualization and model interpretation. Furthermore, the UNQRT estimates noncrossing multiple quantile functions simultaneously by enforcing noncrossing constraints, resulting in the improvement of prediction accuracy. The numerical results are presented to demonstrate the competitive performance of the proposed UNQRT over QRT. Supplementary materials for this article are available online. 相似文献
Asymmetric synthesis of α-substituted proline derivatives has been accomplished by an efficient chirality-transfer method. High diastereoselectivity of the N-alkylation of the proline ester (C→N chirality transfer) was achieved when a 2,3-disubstituted benzyl group was used as the N-substituent. DFT calculations provided a mechanistic rationale for the high degree of stereoselectivity. The generated N-chirality of the quaternary ammonium salt was transferred back to the α-carbon through a stereoselective [2,3]-Stevens rearrangement (N→C chirality transfer) to give α-substituted proline ester. 相似文献