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101.
Inulae Flos, the flower of Inula britannica L., is used as a dietary supplement, beverage, and medicine in East Asia. In this study, we evaluated the gastroprotective effects of Inulae Flos extract (IFE) against gastric mucosal lesions induced by hydrochloric acid (HCl)/ethanol in rats and explored its potential mechanisms by measuring antioxidant enzyme activity, mucus secretion, and prostaglandin E2 (PGE2) levels. Pretreatment with IFE at doses of 100 and 300 mg/kg significantly inhibited gastric lesions in HCl/ethanol-treated rats. IFE increased the activities of superoxide dismutase and catalase and the levels of glutathione and PGE2 in gastric tissues. The administration of IFE also significantly increased the gastric wall mucus contents in HCl/ethanol-induced gastric lesions. These findings suggest that IFE has gastroprotective effects against HCl/ethanol-induced gastric lesions and exerts these effects through increased antioxidant levels and gastric mucus secretion. Inulae Flos may be a promising agent for the prevention and treatment of gastritis and gastric ulcers. 相似文献
102.
Eunsoo Lee Hyounmyung Park Hyunkeun Joo Boniface P. T. Fokwa 《Angewandte Chemie (International ed. in English)》2020,59(29):11774-11778
Transition‐metal borides (TMBs) have recently attracted attention as excellent hydrogen evolution (HER) electrocatalysts in bulk crystalline materials. Herein, we show for the first time that VB and V3B4 have high electrocatalytic HER activity. Furthermore, we show that the HER activity (in 0.5 m H2SO4) increases with increasing boron chain condensation in vanadium borides: Using a ?23 mV overpotential decrement derived from ?0.296 mV (for VB at ?10 mA cm?2 current density) and ?0.273 mV (for V3B4) we accurately predict the overpotential of VB2 (?0.204 mV) as well as that of unstudied V2B3 (?0.250 mV) and hypothetical “V5B8” (?0.227 mV). We then derived an exponential equation that predicts the overpotentials of known and hypothetical VxBy phases containing at least a boron chain. These results provide a direct correlation between crystal structure and HER activity, thus paving the way for the design of even better electrocatalytic materials through structure–activity relationships. 相似文献
103.
Hyejin Hyeon Ho Bong Hyun Boram Go Sung Chun Kim Yong-Hwan Jung Young-Min Ham 《Molecules (Basel, Switzerland)》2022,27(1)
Magnolia flower buds are a source of herbal medicines with various active compounds. In this study, differences in the distribution and abundance of major essential oils, phenolic acids, and primary metabolites between white flower buds of Magnolia heptapeta and violet flower buds of Magnolia denudata var. purpurascens were characterised. A multivariate analysis revealed clear separation between the white and violet flower buds with respect to primary and secondary metabolites closely related to metabolic systems. White flower buds contained large amounts of monoterpene hydrocarbons (MH), phenolic acids, aromatic amino acids, and monosaccharides, related to the production of isoprenes, as MH precursors, and the activity of MH synthase. However, concentrations of β-myrcene, a major MH compound, were higher in violet flower buds than in white flower buds, possibly due to higher threonine levels and low acidic conditions induced by comparatively low levels of some organic acids. Moreover, levels of stress-related metabolites, such as oxygenated monoterpenes, proline, and glutamic acid, were higher in violet flower buds than in white flower buds. Our results support the feasibility of metabolic profiling for the identification of phytochemical differences and improve our understanding of the correlated biological pathways for primary and secondary metabolites. 相似文献
104.
105.
Matrix metalloproteinases (MMPs), key molecules of cancer invasion and metastasis, degrade the extracellular matrix and cell–cell adhesion molecules. MMP-10 plays a crucial role in Helicobacter pylori-induced cell-invasion. The mitogen-activated protein kinase (MAPK) signaling pathway, which activates activator protein-1 (AP-1), is known to mediate MMP expression. Infection with H. pylori, a Gram-negative bacterium, is associated with gastric cancer development. A toxic factor induced by H. pylori infection is reactive oxygen species (ROS), which activate MAPK signaling in gastric epithelial cells. Peroxisome proliferator-activated receptor γ (PPAR-γ) mediates the expression of antioxidant enzymes including catalase. β-Carotene, a red-orange pigment, exerts antioxidant and anti-inflammatory properties. We aimed to investigate whether β-carotene inhibits H. pylori-induced MMP expression and cell invasion in gastric epithelial AGS (gastric adenocarcinoma) cells. We found that H. pylori induced MMP-10 expression and increased cell invasion via the activation of MAPKs and AP-1 in gastric epithelial cells. Specific inhibitors of MAPKs suppressed H. pylori-induced MMP-10 expression, suggesting that H. pylori induces MMP-10 expression through MAPKs. β-Carotene inhibited the H. pylori-induced activation of MAPKs and AP-1, expression of MMP-10, and cell invasion. Additionally, it promoted the expression of PPAR-γ and catalase, which reduced ROS levels in H. pylori-infected cells. In conclusion, β-carotene exerts an inhibitory effect on MAPK-mediated MMP-10 expression and cell invasion by increasing PPAR-γ-mediated catalase expression and reducing ROS levels in H. pylori-infected gastric epithelial cells. 相似文献
106.
Min‐kyoung Ham Ji HoYouk Yong‐Ku Kwon Young‐Je Kwark 《Journal of polymer science. Part A, Polymer chemistry》2012,50(12):2389-2397
A photoinitiation process was investigated to develop a rapid and well‐controlled RAFT polymerization method applied to vinyl acetate (VAc) using methyl (ethoxycarbonothioyl)sulfanyl acetate (MESA) and bis(2,4,6‐trimethylbenzoyl)phenylphosphine oxide as the RAFT agent and photoinitiator, respectively. MESA was selected as the photochemically inert RAFT agent to minimize photolysis of the thiocarbonylthio groups during polymerization. Poly(vinyl acetate) with a prespecified well‐controlled molecular weight (MW) and a narrow MW distribution was successfully synthesized. The polymerization reaction proceeded as a living polymerization and was remarkably rapid compared with approaches that use thermally initiated processes with a very short induction period. A detailed kinetic study of the mechanism underlying the polymerization reaction, however, revealed that the chain ends containing xanthate moieties were not perfectly stable upon UV‐irradiation, and they generated radicals via homolytic cleavage. This reaction appeared to proceed by a combination of a degenerative transfer RAFT mechanism and a dissociation‐combination mechanism. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012 相似文献
107.
108.
High-frequency ultrasound (HFUS) signals backscattered from RBL-2H3 cell pellets prepared under different centrifugal forces were analyzed to investigate the packing effect of cell aggregates. The measurements were performed in a pulse-echo setup with a 40-MHz transducer. The changes of ultrasound signals from cell pellet in backscattered power, statistical parameter, and pellet thickness were monitored after centrifugation at between 100g and 1600g. Experimental results showed that the HFUS backscattered power from cell pellets was inversely proportional to centrifugal force and increased to a plateau within 1-2 h after centrifugation. The initial thickness of cell pellets decreased with higher centrifugal force, but the changes in thickness and time that took to reach a plateau increased at higher centrifugal force. The envelope statistics of backscattered signals with Nakagami distribution indicates that the centrifugal force and elapsed time after centrifugation affected the backscattering characteristics. The present study suggests that centrifugal force and data acquisition time after cell pellet formation should be considered in in vitro cell packing method with centrifugation to emulate the tissue in vivo. 相似文献
109.
110.
Song CE Jung DU Roh EJ Lee SG Chi DY 《Chemical communications (Cambridge, England)》2002,(24):3038-3039
In Os-catalysed asymmetric dihydroxylation using NMO as a co-oxidant, the combination of an ionic liquid and the new bis-cinchona alkaloid 2 generated in situ from (QN)2PHAL during reaction provided a simple and practical approach to the recycling of both catalytic components (osmium tetraoxide and chiral ligand). 相似文献