Extraction and isolation of catechins from tea

Tea is a major source of catechins, which have become well known for their antioxidant potential. Numerous human, animal, and in vitro studies have linked tea catechins with prevention of certain types of cancers, reduction of the risks for obesity, diabetes, and cardiovascular disease, and improvement of the immune system. Tea catechins are widely used in various neutraceuticals, pharmaceuticals, and cosmetics for either enhancing product shelf-life or for enhancing human health. Thus, the demand for catechins has increased considerably. Catechins have been extracted and isolated from tea leaves by numerous methods through several steps including: treatment of the tea leaves, extraction of catechins from teas into solvents, isolation of catechins from other extracted components, and drying the preparations to obtain catechin extracts in a powder form. This paper outlines the physical and chemical properties of the tea catechins and reviews the extraction steps of the various extraction methods, as a basis to improve and further develop the extraction and isolation of the tea catechins.     

The cellulose system in viscin from mistletoe berries

The cellulose system of the viscous fibrous cellulosic polysaccharide (viscan) in the viscin tissue of the European mistletoe, Viscum album L., was analyzed by chemical and physicochemical techniques including sugar analysis, optical and transmission electron microscopy, X-ray and electron diffraction together with solid state CP/MAS ¹³C-NMR spectroscopy. The results confirmed that in the elongated thin viscin cells, the cellulose microfibrils (having a diameter of around 3 nm) were tightly coiled with their axes perpendicular to the long axis of the cell. Upon stretching these cells became deformed by more than a hundred fold. In such a deformation, the cellulose microfibrils became unwound to be perfectly aligned along the stretching direction. Based on solid-state CP/MAS ¹³C-NMR spectroscopic analysis of the viscin tissue, it was found that its cellulose consisted of I and I polymorphs in the ratio 1:1.     

Synthesis of substituted 5-aminomethyl tetrahydro-isoquinolines and dihydro-isoindoles

The synthesis of ten substituted aminomethylene tetrahydro-isoquinolines is described, proceeding in eight steps from 5-hydroxyisoquinoline via reductive amination of N-Boc tetrahydro-isoquinoline 5-carboxaldehyde. Likewise, reductive amination was used to prepare four substituted dihydro-isoindoles from the corresponding aldehyde. The dihydro-isoindole ring system was conveniently accessed via a 2+2+2 cycloaddition reaction.     

Monte Carlo simulation and theory of proton NMR transverse relaxation induced by aggregation of magnetic particles used as MRI contrast agents

Superparamagnetic particles are widely used in MRI as R2 contrast agents. In this last decade, different studies have focused on aggregation of superparamagnetic particles for important applications such as multimodal agents. A complete study--via simulations--of the influence of aggregation on the MR efficiency of these particles at high magnetic field is presented here. First, an empirical expression is proposed for R2 in the presence of uniformly distributed nanoparticles, taking into account two regimes at once (motional averaging and slow motion regimes). Three cluster shapes are simulated: Sphere, shell and line. An analytical model is proposed to understand water transverse relaxation induced by spherical and shell aggregates. Simulations lead to the conclusion that, in the motional averaging regime, the most efficient aggregate contrast agent is the densest sphere or shell.     

Collapse and stability of necklace beams in Kerr media

We investigate the spatial dynamics of optical necklace beams in Kerr media. For powers corresponding to less than the critical power for self-focusing per bead, we experimentally confirm the confinement of these necklace beams as proposed in [Phys. Rev. Lett. 81, 4851 (1998)10.1103/PhysRevLett.81.4851]. At higher powers, we observe a transition from collective necklace behavior to one in which the beads of the necklace collapse independently. We observe that, below the transition power, the perturbed necklace still behaves in a collective manner with coupling between individual beads but that, at higher powers, it undergoes a similar transition to a decoupled state of the necklace.     

Evaluation of interfacial toughness curve of bimaterial in submicron scale

A novel method combining the experimental data at only two different mixed mode fractures and an empirical interface toughness function has been proposed to establish the interfacial toughness function of a bimaterial in submicron scale. The modified four-point bend specimen was used in experiment to evaluate the first type of mixed mode fracture, while the sandwiched cantilever specimen was employed to get the second one. An empirical interface toughness function reflecting quite accurately the delamination behavior was adopted as a typical one. The obtained results investigated that the proposed method could be used to calibrate not only the interfacial fracture criteria at pure modes but also at any mixed mode fracture of bimaterials in submicron scale.     

Synthesen,IR- und 15N-Kernresonanzspektren isotopen-markierter Nitridokomplexe des Wolframs

Isothermal Section at 1273 K in the System Ti? Si? O The isothermal section at 1273 K of the system Ti? Si? O has been investigated by means of phase analysis in quenched samples as well as by the investigation of the phase sequence in chemical vapour transport experiments. In equilibrium with SiO₂ only TiSi₂, TiSi, and Ti₅Si₃(O), respectively, can coexist as Si-containing compounds. Only Ti₅Si₃(O) can coexist with titanium oxides (Ti₂O₃ or TiO, respectively). Ti₅Si₄ is stable only if oxygen is absent.     

Detection of the spermicide nonoxynol-9 via GC-MS

The spermicide nonoxynol-9 is actually a complex mixture of dozens of closely related amphiphilic compounds, and the chemical properties of this assortment significantly hamper its characterization by GC-MS. The inability to perform routine GC-MS testing on nonoxynol-9 has limited its evidentiary value in forensic casework, which relies heavily on this technique for analysis. A disturbing trend in sexual assault is the use of condoms by assailants, to avoid leaving behind DNA evidence that can connect a perpetrator to a victim. This observation necessitates the development of alternative methods for the analysis of trace evidence that can show causal links between a victim and a suspect. Detection of lubricants associated with sexual assault is one such way to establish this connection. The development of GC-MS methods that permit facile detection of both nonoxynol-9 alone and nonoxynol-9 extracted from other complex matrices that have potential as trace evidence in sexual assault is reported. A detection limit of 2.14 μg of nonoxynol-9 is demonstrated, and a detailed mass spectral profile that elaborates on what is known of its structure is provided.