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681.
Electromagnetically-induced transparency (EIT) in three-level Λ-systems is based on quantum interference effects involving
coherence between the two lower levels, which allow propagation of a resonant probe light beam in the presence of a strong
coupling field. We have observed transparency in ultra-narrow (<10 kHz) windows at the resonant 1.083 μm transition for purely
electronic spins in gaseous 4He* at room temperature. Slow light is an interesting outcome of the EIT phenomenon due to extreme dispersion within the narrow
transparency window. We have obtained group delays of about 4 μs in a 2.5 cm long He* cell. A complete theoretical analysis
explains our observations emphasizing the positive role of collisions. Slow light with 1-GHz Doppler broadening opens the
door to applications of controllable large-bandwidth delays in radars. 相似文献
682.
Dan Xu Ya-Hui Hu Xue Gou Feng-Yang Li Xi-Yu-Chen Yang Yun-Man Li Feng Chen 《Molecules (Basel, Switzerland)》2022,27(12)
Pulmonary arterial hypertension (PAH) is clinically characterized by a progressive increase in pulmonary artery pressure, followed by right ventricular hypertrophy and subsequently right heart failure. The underlying mechanism of PAH includes endothelial dysfunction and intimal smooth muscle proliferation. Numerous studies have shown that oxidative stress is critical in the pathophysiology of PAH and involves changes in reactive oxygen species (ROS), reactive nitrogen (RNS), and nitric oxide (NO) signaling pathways. Disrupted ROS and NO signaling pathways cause the proliferation of pulmonary arterial endothelial cells (PAECs) and pulmonary vascular smooth muscle cells (PASMCs), resulting in DNA damage, metabolic abnormalities, and vascular remodeling. Antioxidant treatment has become a main area of research for the treatment of PAH. This review mainly introduces oxidative stress in the pathogenesis of PAH and antioxidative therapies and explains why targeting oxidative stress is a valid strategy for PAH treatment. 相似文献
683.
Yong-liang Zhu Hao-zhe Ding Kai-feng Gou Bo Sun Ye Chen He-wei Zhang 《Biomedical chromatography : BMC》2023,37(1):e5504
A reliable and sensitive ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed for the determination of zanubrutinib in the plasma of beagle dogs. The column used was an Acquity BEH C18 column (2.1 mm × 50 mm, 1.7 μm), maintained at 40°C with an injection volume of 2 μl. The gradient elution program was as follows: 0–1 min, 10–10% A; 1–1.1 min, 10–90% A; 1.1–2.1 min, 90–90% A; 2.1–2.2 min, 90–10% A; 2.2–3.0 min, 10–10% A. Mobile phase A was 0.1% formic acid, B was acetonitrile, and the total analysis time was 3 min. The mass spectrometry was performed in positive ion mode, and the scanning mode was multi-reaction monitoring mode with electrospray ionization as the ion source; m/z 472.2 → 455.01 for zanubrutinib and m/z 441.03 → 137.99 for ibrutinib (internal standard). The plasma samples were processed by protein precipitation. The standard curve showed good linearity (r2 = 0.999 8) in the range of 1.0–1,000 ng/ml (zanubrutinib) with a low limit of quantification of 1 ng/ml. Also, the intra-day and inter-day precision (RSD) was <5.88% and the accuracy (RE) ranged from −1.56 to 1.08%; the recoveries of zanubrutinib in beagle plasma ranged from 90.12 to 93.53% (RSD 1.67–6.42%) and the ME values of zanubrutinib were 98.70–101.06% (RSD 5.37–8.49%, n = 6). All values meet US Food and Drug Administration requirements. A rapid, highly selective and sensitive method for the determination of zanubrutinib concentration in plasma by UPLC–MS/MS was successfully developed. This method is suitable for pharmacokinetic studies in beagle dogs by following oral administration of zanubrutinib. 相似文献
684.
用SGV-50型正入射式真空紫外谱仪拍摄了三电极触发火花光源的Zn的高离化光谱。在光谱分析方法研究基础上、对Zn光谱进行了分析。证实了ZnⅢ、ZnⅣ和ZnⅤ的3d~k4s和3d~k4p(k=9,8,7)组态现有光谱的分析结果。通过ZnⅣ3d~84d-3d~84p组态跃迁的分析导出了3d~84d组态的19条能级。 相似文献
685.
Haipei Zhao Xuehao Xiu Dr. Mingqiang Li Prof. Shaobo Dai Mingyang Gou Leyang Tao Prof. Xiaolei Zuo Prof. Chunhai Fan Prof. Zhongqun Tian Prof. Ping Song 《Angewandte Chemie (International ed. in English)》2023,62(14):e202214450
Dynamic interactions of enzymes, including programmable configuration and cycling of enzymes, play important roles in the regulation of cellular metabolism. Here, we constructed a super DNA-enzymes molecule (SDEM) that comprises at least two cascade enzymes and multiple linked DNA strands to control and detect metabolism. We found that the programmable SDEM, which comprises glucose oxidase (GOx) and horseradish peroxidase (HRP), has a 20-fold lower detection limit and a 1.6-fold higher reaction rate than free enzymes. An SDEM can be assembled and disassembled using a hairpin structure and a displacement DNA strand to complete multiple cycles. An entropically driven catalytic assembly (catassembly) enables different SDEMs to switch from an SDEM with GOx and HRP cascades to an SDEM with sarcosine oxidase (SOX) and HRP cascades in over six orders of magnitude less time than without the catassembly to detect different metabolisms (GO and sarcosine) on demand. 相似文献
686.
Yanhong Ma Bixing Gao Jingliang Qi Yan Gou Zhi Li Yingxin Chen Min Li Juan Zhou Lian Zhong Xiaoyang Cai 《Biomedical chromatography : BMC》2023,37(1):e5526
Because of the immense difficulty in identifying Cyathulae Capitatae Radix adulteration in Cyathulae Radix, this research aims at fortifying the quality control of Cyathulae Radix and its decoction pieces to guarantee the effectiveness and safety of its clinical use in terms of source material. A method was devised to identify Cyathulae Capitatae Radix adulteration in Cyathulae Radix and its decoction pieces. This research takes achybidensaponin I, that is, the characteristic component of Cyathulae Capitatae Radix, as reference substance and adopts HPLC for detection. The results revealed that, among all samples collected, no trace of achybidensaponin I was found in the 21 batches of Cyathulae Radix, whereas achybidensaponin I was found in all the 14 batches of Cyathulae Capitatae Radix. The research sets 5% as the adulteration limit, that is, 1.45 mg/g Cyathulae Capitatae Radix was detected in 57.14% of the 49 batches of market samples collected and the ratio was 51.02% in the case of 5% adulteration limit. The method is not only precise and reliable but can also be used as a supplement for provisions regarding quality control of Cyathulae Radix and its decoction pieces in Pharmacopoeia of the People's Republic of China, to effectively crack down on Cyathulae Capitatae Radix adulteration in the market. 相似文献
687.
Gou Lei Yang Yang Zhang Yunfei Li Junru Fan Xiaoyong Li Donglin 《Journal of Solid State Electrochemistry》2023,27(6):1443-1450
Journal of Solid State Electrochemistry - Bi3+-doped δ-MnO2 materials (BMX, X = 5, 10, 15) with long cycle life were obtained by an in situ electrochemical reaction using... 相似文献