Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury

Advanced glycation end products (AGEs) are potentially harmful and heterogeneous molecules derived from nonenzymatic glycation. The pathological implications of AGEs are ascribed to their ability to promote oxidative stress, inflammation, and apoptosis. Recent studies in basic and translational research have revealed the contributing roles of AGEs in the development and progression of various aging-related pathological conditions, such as diabetes, cardiovascular complications, gut microbiome-associated illnesses, liver or neurodegenerative diseases, and cancer. Excessive chronic and/or acute binge consumption of alcohol (ethanol), a widely consumed addictive substance, is known to cause more than 200 diseases, including alcohol use disorder (addiction), alcoholic liver disease, and brain damage. However, despite the considerable amount of research in this area, the underlying molecular mechanisms by which alcohol abuse causes cellular toxicity and organ damage remain to be further characterized. In this review, we first briefly describe the properties of AGEs: their formation, accumulation, and receptor interactions. We then focus on the causative functions of AGEs that impact various aging-related diseases. We also highlight the biological connection of AGE–alcohol–adduct formations to alcohol-mediated tissue injury. Finally, we describe the potential translational research opportunities for treatment of various AGE- and/or alcohol-related adduct-associated disorders according to the mechanistic insights presented.Subject terms: Medical research, Experimental models of disease     

Coordination numbers for rigid spheres and local compositions

The coordination numbers of rigid spheres were simulated on a computer to obtain an improved empirical equation when surrounding spheres are of uniform size. In the case of two different species of surrounding spheres, the coordination numbers vary as a function of local composition and radius ratios. By fitting simulation results, correlations were proposed, which are expected to be of practical use in thermodynamic of real solutions.     

非齐次对称特征值问题

引言 用SR~(n×n)表示所有。n×n实对称矩阵的集合。R~n表示n维线性空间。||·||_2表示向量的Euclid范数或矩阵的谱范数。 本文研究如下问题: 问题ISEP 给定矩阵A∈SR~n×n和向量b∈R~n,求实数λ和向量X∈R~n使得 AX=λX+b, (1) ||X||_2=1. (2) 若b=0,则问题ISEP就是通常的实对称矩阵特征值问题,若b≠0,则问题ISEP称为非齐次对称特征值问题,使(1)和(2)式成立的数λ和向量X分别称为非齐次特征值和相应的非齐     

Group Classification and Generalized Conditional Symmetry Reduction of the Nonlinear Diffusion–Convection Equation with a Nonlinear Source

The generalized conditional symmetry method, which can be considered a generalization of the conditional symmetry method, is used to study the nonlinear diffusion–convection equations with a nonlinear source. In particular, exponential and power law diffusivities are examined and we obtain mathematical forms of the convective term and the source term, which permit the generalized conditional symmetry reductions. A number of examples are considered and some exact solutions are constructed via the compatibility of the generalized conditional symmetry and the considered equation.     

细胞动力学研究Ⅴ.细胞连续增长热动力学

用微量热法测定了布鲁氏菌Ｍ５（５５０１０）和８３－９８１在２７℃和４０℃时的生长发热功率曲线．由这些生长发热功率曲线，建立了细胞有限条件下连续增长热动力学方程：ｌｎ（Ｐｍ／Ｐｔ－１）＝ｌｎ（Ｐｍ／Ｐ０－１）－ｋｔ从而求出了细菌的生长常数ｋ．这个方程非常适合“Ｓ”型的生长发热功率曲线     

Multiple singular manifold method and extended direct method: Application to the burgers equation

This paper considers the relationship between the multiple singular manifold method (MSMM) and the extended direct method (EDM) for studying partial differential equations. It is shown that the similarity reductions using EDM can be obtained by MSMM. The prototype example for illustrating the approach is the Burgers equation, which is the simplest evolution equation to embody nonlinearity and dissipation. As a conclusion of the MSMM, we obtain a set of Bäcklund transformations of the Burgers equation.     

Generation of millimeter-wave in optical pulse carrier by using an apodized Moiré fiber grating

A novel scheme is proposed to transform a Gaussian pulse to a millimeter-wave frequency modulation pulse by using an apodized Moiré fiber Bragg grating in radio-over-fiber system. The relation between the input and output pulses is analyzed theoretically by Fourier transformation method and the requirements for the proposed fiber grating are presented. An apodized Moiré fiber Bragg grating is designed and its characteristics are studied. It is shown that the proposed device is feasible, and the new scheme is believed to be an effective solution for the generation of millimeter-wave sub-carrier in future radio-over-fiber systems.     

Synthesis of Fe-based amorphous composite coatings with low purity materials by laser cladding

Amorphous composite coatings Fe₃₈Ni_30−XSi₁₆B₁₄V₂M_X (X = 0, 1, 2) (M contains Al, Ti, Mo, and C) were prepared with low purity of raw materials by laser cladding. X-ray diffraction and transmission electron microscopy results show that the coating have an amorphous structure with a few crystalline phase on it. The amorphous phase is the primary phase. The glass forming ability as well as the microhardness of the Fe-based alloy made from low purity raw materials can be much enhanced by adding small amount of multi-components. However, the elements addition has its optimal quantity. When X is equal to 1, the microstructure of the coating contains 97.93% amorphous phase and 2.07% crystalline phase on it. As a result, the microhardness of the coating reaches maximum. With further increasing of the additions, the amorphous phase in the coating lessens instead of augment and the crystalline phase begins to accumulate, which result in the decrease of the microhardness.     

Action du n-butyllithium sur les bromo-3 halogeno-2 pyridines fluoree,chloree et bromee : Principe et etude d'une possibilite reactionnelle nouvelle : l'homotransmetallation

Apart from the common bromine-lithium exchange reaction in brominated aromatic compounds, it is possible to obtain a lithio-derivative quite different from the one usually described in such a reaction. This new reaction, which results from a special experimental conditions is called ·homotransmetalation”, and it occurs when using n-butyllithium and 3-bromo 2-halogenopyridines (1). Different behaviour is observed with the three similar compounds (1: X = F,Cl,Br). Explanations are proposed of these results. It is then possible to compare the relative stabilities of the proposed lithio-structures. It is evident that nucleophilic substitution of bromine in position 4 of the pyridine ring is easier than is usually recognised.