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991.
Kristelle Hughes Raimana Ho Stphane Greff Gaëtan Herbette Edith Filaire Edwige Ranouille Jean-Yves Berthon Phila Raharivelomanana 《Molecules (Basel, Switzerland)》2022,27(1)
The term cosmetopoeia refers to the use of plants in folks’ cosmetics. The aerial parts of Bidens pilosa L., the leaves of Calophyllum inophyllum L. and the fruits of Fagraea berteroana A.Gray ex Benth are traditionally used in French Polynesia for hair and skin care. During the hair cycle, dermal papilla cells and their interaction with epithelial cells are essential to promote hair follicle elongation. The aim of our investigations was the identification of metabolites from these three plants and chemical families responsible for their hair growth activity. A bioactivity-based molecular network was produced by mapping the correlation between features obtained from LC-MS/MS data and dermal papilla cell proliferation, using the Pearson correlation coefficient. The analyses pointed out glycosylated flavonols and phenolic acids from B. pilosa and C. inophyllum, along with C-flavonoids, iridoids and secoiridoids from F. berteroana, as potential bioactive molecules involved in the proliferation of hair follicle dermal papilla cells. Our results highlight the metabolites of the plant species potentially involved in the induction of hair follicle growth and support the traditional uses of these plants in hair care. 相似文献
992.
Tu Sun Dr. Colan E. Hughes Linshuo Guo Lei Wei Prof. Kenneth D. M. Harris Prof. Yue-Biao Zhang Prof. Yanhang Ma 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(50):22827-22833
Structure determination of covalent organic frameworks (COFs) with atomic precision is a bottleneck that hinders the development of COF chemistry. Although three-dimensional electron diffraction (3D-ED) data has been used to solve structures of sub-micrometer-sized COFs, successful structure solution is not guaranteed as the data resolution is usually low. We demonstrate that the direct-space strategy for structure solution, implemented using a genetic algorithm (GA), is a successful approach for structure determination of COF-300 from 3D-ED data. Structural models with different geometric constraints were considered in the GA calculations, with successful structure solution achieved from room-temperature 3D-ED data with a resolution as low as ca. 3.78 Å. The generality of this strategy was further verified for different phases of COF-300. This study demonstrates a viable strategy for structure solution of COF materials from 3D-ED data of limited resolution, which may facilitate the discovery of new COF materials in the future. 相似文献
993.
Okba Al Rahal Colan E. Hughes P. Andrew Williams Andrew J. Logsdail Yael Diskin‐Posner Kenneth D. M. Harris 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(52):18964-18968
A new polymorph of l ‐tryptophan was prepared through crystallization from the gas phase, with structure determination carried out directly from powder XRD data augmented by periodic DFT‐D calculations. The new polymorph (denoted β) and the previously reported polymorph (denoted α) are both based on alternating hydrophilic and hydrophobic layers, but with substantially different hydrogen‐bonding arrangements. The β polymorph exhibits the energetically favourable l 2‐l 2 hydrogen‐bonding arrangement, which is unprecedented for amino acids with aromatic side chains. The specific molecular conformations adopted in the β polymorph facilitate this hydrogen‐bonding scheme while avoiding steric conflict of the side chains. 相似文献
994.
Frontispiece: Synthesis of Meso‐Substituted Subphthalocyanine–Subporphyrin Hybrids: Boron Subtribenzodiazaporphyrins 下载免费PDF全文
995.
A palladium composite membrane with a large number of defects was repaired using the electroless plating combined with the technique of osmosis. The loose structure of palladium film prepared by the conventional electroless plating was densified. Defects were repaired. Hydrogen selectivity was thus significantly increased without significantly increasing palladium film thickness and reducing hydrogen permeability. 相似文献
996.
The TECRA Staphylococcus aureus Visual Immunoassay allows a presumptive positive or negative result for the presence of S. aureus to be obtained within 26 h, in contrast to 4-5 days by traditional cultural methods. Presumptive positive immunoassay results are confirmed by streaking the enrichment broth onto conventional agar media. A validation study was undertaken to compare the TECRA assay with a cultural reference method based on the Bacteriological Analytical Manual (8th Ed.), which is also consistent with U.S. Pharmacopoeia requirements. The products tested included a range of cosmetics (toothpaste, shampoos, conditioners, sunscreens, moisturizers, lip and eye creams) and pharmaceuticals (cough mixtures, laxatives, ulcer treatments, infant formulae, antiseptic cream), as well as some pharmaceutical ingredients. Samples were inoculated with S. aureus at 10-20 cfu/g, and then enriched for 24 h at 35 degrees-37 degrees C at a product-to-sample ratio of 1:100. Two different enrichment broths were used for the study: Tryptone Soya Broth with 4% Tween 80 and Modified Letheen Broth. For both enrichment broths, results of the immunoassay and the reference method showed close correlation. The TECRA S. aureus Visual Immunoassay provides a rapid and convenient alternative to cultural methods and provides advantages to industry, such as greater speed of product and ingredient release and faster tracing of contamination problems. Because the immunoassay may be read either visually or with the aid of a plate reader, there is no need for an initial outlay on capital equipment. However, the assay can be automated if required. 相似文献
997.
Jiaming Peng Dr. Gregory R. Hughes Prof. Dr. Manuel M. Müller Prof. Dr. Florian P. Seebeck 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2024,136(1):e202312104
S-adenosylmethionine-dependent methyltransferases are involved in countless biological processes, including signal transduction, epigenetics, natural product biosynthesis, and detoxification. Only a handful of carboxylate methyltransferases have evolved to participate in amide bond formation. In this report we show that enzyme-catalyzed F-methylation of carboxylate substrates produces F-methyl esters that readily react with N- or S-nucleophiles under physiological conditions. We demonstrate the applicability of this approach to the synthesis of small amides, hydroxamates, and thioesters, as well as to site-specific protein modification and native chemical ligation. 相似文献
998.
Jing Xue Jason M. Hughes Ellak I. Von Nagy-Felsobuki 《Journal of heterocyclic chemistry》1996,33(6):1751-1758
The ultraviolet photoelectron spectra (UPS) of 3-fluoro-, 3- chloro-, 3-bromo- and 3- iodopyridine were recorded and interpreted using a composite-molecule model. The sequence of the four lowest ionization energies for 3-fluoro- and 3-chloropyridine is: π3 (1a2) < nN (11a1)ππ2 (2b1)π∼pyr (7b2), whereas for 3-bromo- and 3-iodopyridine the assignment is: π3 (1a2) - πxπnN (11a1)πσx π2 (2b1) (where X represents a bromine or iodine lone-pair). Comparison of the HeI and HeII band intensities and correlations with the UPS assignment of the 2-halopyridines confirm this sequence. However, ab initio calculations using the STO-3G*//STO-3G* and 6–31G**//STO-3G* models do not agree with either the composite-molecule model, simple UPS correlations and HeI/HeII cross-section ratios. For 3-fluoropyridine, the HAM/3 model was in agreement with the proposed assignment. 相似文献
999.
1000.