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101.
Le Thi Phuong Ngoc Nguyen Thanh Long 《Nonlinear Analysis: Theory, Methods & Applications》2011,74(11):3769-3774
Using a fixed point theorem of Krasnosel’skii type, the paper proves the existence of asymptotically stable solutions for a Volterra-Hammerstein integral equation. 相似文献
102.
In this work, we will prove the Dugundji extension theorem for the cone metric space. It is heavily reliant on the paracompactness of the cone topology that is proved by Ayse Sönmez in the paper Sönmez (2010) [11]. 相似文献
103.
Hydrolysis of dipeptides glycylserine (Gly-Ser), leucylserine (Leu-Ser), histidylserine (His-Ser), glycylalanine (Gly-Ala), and serylglycine (Ser-Gly) was examined in vanadate solutions by means of (1)H, (13)C, and (51)V NMR spectroscopy. In the presence of a mixture of oxovanadates, the hydrolysis of the peptide bond in Gly-Ser proceeds under the physiological pH and temperature (37 °C, pD 7.4) with a rate constant of 8.9 × 10(-8) s(-1). NMR and EPR spectra did not show evidence for the formation of paramagnetic species, excluding the possibility of V(V) reduction to V(IV) and indicating that the cleavage of the peptide bond is purely hydrolytic. The pD dependence of k(obs) exhibits a bell-shaped profile, with the fastest hydrolysis observed at pD 7.4. Combined (1)H, (13)C, and (51)V NMR experiments revealed formation of three complexes between Gly-Ser and vanadate, of which only one complex, designated Complex 2, formed via coordination of amide oxygen and amino nitrogen to vanadate, is proposed to be hydrolytically active. Kinetic experiments at pD 7.4 performed by using a fixed amount of Gly-Ser and increasing amounts of Na(3)VO(4) allowed calculation of the formation constant for the Gly-Ser/VO(4)(3-) complex (K(f) = 16.1 M(-1)). The structure of the hydrolytically active Complex 2 is suggested also on the basis of DFT calculations. The energy difference between Complex 2 and the major complex detected in the reaction mixture, Complex 1, is calculated to be 7.1 kcal/mol in favor of the latter. The analysis of the molecular properties of Gly-Ser and their change upon different modes of coordination to the vanadate pointed out that only in Complex 2 the amide carbon is suitable for attack by the hydroxyl group in the Ser side chain, which acts as an effective nucleophile. The origin of the hydrolytic activity of vanadate is most likely a combination of the polarization of amide oxygen in Gly-Ser due to the binding to vanadate, followed by the intramolecular attack of the Ser hydroxyl group. 相似文献
104.
We study ${W^{2,m(\cdot)}_{loc}}$ regularity for local weak solutions of p(·)-Laplace equations where ${p\in C^1(\Omega) \cap C(\overline{\Omega})}$ and ${\min_{x\in \overline{\Omega}} p(x) > 1}$ . 相似文献
105.
Nguyen Thi Thuy Phuong Dinh Tam Mai Anh Tuan Anh-Tuan Le Le Thi Tam Vu Van Thu Nguyen Van Hieu Nguyen Duc Chien 《Current Applied Physics》2012,12(6):1553-1560
The present paper introduces a facile and cost-effective route for the direct dispersion of multi-walled carbon nanotubes (MWCNTs) in DNA solution. Their application in detecting Escherichia coli O157:H7 using DNA biosensor was demonstrated. The dispersion state of the MWCNTs was characterized via UV–Vis spectroscopy, transmission electron microscopy, and field emission scanning electron microscopy. The interaction between DNA sequence and the MWCNTs was investigated using Raman spectroscopy and Fourier transform infrared spectroscopy. As-obtained MWCNT solution was used in the preparation of DNA sensor. Results revealed that the developed DNA sensor can detect a DNA target as low as 1 nM in a buffer solution. The sensitivity of the DNA sensor reached approximately 0.19 nM/mV. The effect of dispersion parameters, including pH values, DNA concentration, ion strength, and sonication time, on sensor response was also studied. The DNA sensor can respond well to 120 min of sonication time, a pH value of 9, and 20 μM of DNA sequence concentration. The results of the present study showed a potential application of the DNA sensor in the detection of Escherichia coli O157:H7. 相似文献
106.
Phi Hung Tran Thi Ha Do Thi Luyen Nguyen Phuong Thao Nguyen Trong Thong Nguyen 《Natural product research》2019,33(5):695-700
One new and three known compounds were isolated from the ethanol extract of Psychotria prainii aerial parts. By means of spectroscopic methods, their structures were elucidated to be deacetylasperulosidic acid 6-ethyl ether (1), asperulosidic acid (2), asperuloside (3) and obtucarbamates C (4). The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 2 and 4 exhibited strong effect with the IC50 values of 5.75 ± 0.85 and 6.92 ± 0.43 μM, respectively. This is the first report for the chemical composition and biological activity of P. prainii. 相似文献
107.
Ha Phuong Nguyen Sabrina Stewart Mikiembo N. Kukwikila Sioned Fn Jones Daniel Offenbartl‐Stiegert Shiqing Mao Shankar Balasubramanian Stephan Beck Stefan Howorka 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(20):6692-6696
Controlling the functional dynamics of DNA within living cells is essential in biomedical research. Epigenetic modifications such as DNA methylation play a key role in this endeavour. DNA methylation can be controlled by genetic means. Yet there are few chemical tools available for the spatial and temporal modulation of this modification. Herein, we present a small‐molecule approach to modulate DNA methylation with light. The strategy uses a photo‐tuneable version of a clinically used drug (5‐aza‐2′‐deoxycytidine) to alter the catalytic activity of DNA methyltransferases, the enzymes that methylate DNA. After uptake by cells, the photo‐regulated molecule can be light‐controlled to reduce genome‐wide DNA methylation levels in proliferating cells. The chemical tool complements genetic, biochemical, and pharmacological approaches to study the role of DNA methylation in biology and medicine. 相似文献
108.
We calculate the plasmon frequency and damping rate in a double-layer system made of monolayer graphene and GaAs quantum well at finite temperature using the random-phase-approximation dielectric function and taking into account the inhomogeneity of the dielectric background of the system. We show that the temperature, interlayer correlation parameters and dielectric background inhomogeneity affect significantly the plasmon frequencies and damping rates of the system. At low temperatures, acoustic (optical) plasmon frequency increases (decreases) with the increase of temperature. We also find that damping rates of both plasmon modes increase remarkably compared to the zero-temperature case. 相似文献
109.
Vu Van Hung Tran Xuan Linh Vu Thi Thanh Ha Duong Dai Phuong Ho Khac Hieu 《The European Physical Journal B - Condensed Matter and Complex Systems》2018,91(2):44
The elastic moduli and elastic constants of the ternary semiconductor alloy Al y Ga1-yAs at finite temperature have been investigated using the statistical moment method. The Young, shear, bulk moduli and elastic constants C11, C12, C44 of the zinc-blende Al y Ga1?yAs crystal are calculated as functions of Al composition and temperature. Numerical calculations have been performed and compared with those of the experimental and other theoretical results showing the reasonable agreements. Our study shows that elastic moduli and C11, C12 constants of zinc-blende Al y Ga1?yAs alloy are decreasing functions of the temperature and Al composition; C44 constant is a decreasing function of the Al composition. 相似文献
110.