In this study, we demonstrate the preparation of a macroporous monolithic column containing anchored silver nanoparticles and its use for the elimination of excess radioiodine from the radiolabeled pharmaceutical. The poly(glycidyl methacrylate‐co‐ethylene dimethacrylate) monolith was first functionalized with cystamine and the free thiol groups liberated by reaction with borohydride. In‐house‐prepared silver nanoparticles were then attached by interaction with the surface thiols. The deiodization process was demonstrated with the commonly used radiopharmaceutical m‐iodobenzylguanidine labeled with radionuclide iodine‐125. 相似文献
In many computer and server communications copper cables and wires are currently being used for data transmission and interconnects.
However, due to significant shortcomings, such as long transmission time, high noise level, unstable electrical properties,
and high power consumption for cooling, researchers are increasingly turning their research interests toward alternatives,
such as fiber optic interconnects and free-space optical communication technologies. In this paper, we present design considerations
for an integrated receiver for high-speed free-space line-of-sight optical interconnects for distortion-free data transmission
in an environment with mechanical vibrations and air turbulences. The receiver consists of an array of high-speed photodiodes
for data communication and an array of quadrant photodiodes for real-time beam tracking in order to compensate for the beam
misalignment caused by vibrations in servers. Different configurations for spatially positioning the quadrant and data photodiodes
are discussed for 4×4 and 9×9 multielement optical detector arrays. We also introduce a new beam tracking device, termed the
strip quadrant photodiodes, in order to accurately track highly focused optical beams with very small beam diameter. 相似文献
Four carba analogues of oxytocin and a cyclic analogue of melanocyte stimulating hormone were synthesized using solid phase methodology. Purified compounds were shown to be highly biologically active. 相似文献
A branched flexible linker that incorporates a fluorescent dansyl moiety was synthesized and used to connect two high affinity NDP-alpha-MSH ligands or two low affinity MSH(4) ligands. The linker was incorporated into the conjugate by solid-phase synthesis. In vitro biological evaluations showed that potency of binding to the human melanocortin 4 receptor was not diminished for linker-ligand combinations relative to the corresponding ligand alone. 相似文献
Thermoresponsive polymer micelles are promising drug and radionuclide carriers with a strong passive targeting effect into solid tumors. We have synthesized ABA triblock copolymers poly[2‐methyl‐2‐oxazoline‐block‐(2‐isopropyl‐2‐oxazoline‐co‐2‐butyl‐2‐oxazoline)‐block‐2‐methyl‐2‐oxazoline]. These polymers are molecularly dissolved in aqueous millieu below the cloud point temperature (CPT) of the thermoresponsive central block and above CPT form polymer micelles at CMC 5–10 × 10?5 g · mL?1 with diameter ≈200 nm. The phenolic moiety introduced into the copolymer allowed radionuclide labeling with iodine‐125 ongoing in good yield with sufficient in vitro stability under model conditions.
A spray type of singlet oxygen generator for driving the Chemical Oxygen-Iodine Laser was developed. Singlet oxygen, O2(1Δg), is generated by a fast reaction of chlorine with basic hydrogen peroxide solution in the form of a dense spray. A mathematical
model of this reaction system showed that O2(1Δg) can be generated in this system with a high yield (0.70–0.80), high utilization of chlorine (0.75–0.95), and effective utilization
of liquid (0.36–0.54) at very high generator pressures (35–75 kPa). Experimental studies of this reaction system without an
efficient separation of liquid proved an efficient O2(1Δg) production characterized by a rather high product of chlorine utilization and O2(1Δg) yield (0.4–0.9) at very high generator pressures (30–80 kPa). This pressure is much higher than the operation pressure used
in other generators, which should be beneficial for a pressure recovery system of the COIL. These results provided the basis
for designing a centrifugal spray generator with an efficient separation of liquid from the gas flow, which is the subject
of the following paper. 相似文献
An enhanced version of the X(ω1) half-filtered TOCSY experiment for measurement of long-range heteronuclear coupling constants is proposed which yields high-quality spectra with substantially increased sensitivity and resolution. The modified method features gradient-enhanced X filtering sequences, broadband homonuclear decoupling duringt1, optional1JXHscaling in theF1domain, and gradient coherence selection in combination with the sensitivity-enhanced protocol for the TOCSY transfer. These modifications extend the applicability of the method—coupling constants can be measured accurately for natural abundance samples at low concentrations and for compounds yielding complex spectra. Computer-aided analysis of E.COSY-type multiplets is applied for the determination of heteronuclear long-range coupling constants. 相似文献
A centrifugal spray generator of singlet oxygen, O2(1Δg), for driving a chemical oxygen-iodine laser was developed and its operation was experimentally studied. Modeling of the
liquid separation from the gas flow showed that the separator designed could remove droplets larger than 0.5 μm from gas,
which is very important for the laser operation. This result was confirmed by experiments. Experimental studies proved that
O2(1Δg) could be produced with a high efficiency (chlorine utilization 0.68–0.87 and O2(1Δg) yield 0.35–0.7) even at very high generator pressures (25–70 kPa), which cannot be attained by other O2(1Δg) generators. 相似文献