Structures of Ring-Enlargement Products

Crystal structures have been determined of methyl trans-1-hydroxy-6-nitro-3-oxobicyclo[4.4.0]decane-2-carboxylate ( 19 ), cis-3-methyl-6-nitro-2-oxabicyclo[4.4.0]decan-1-ol ( 2 ), cis-7-hydroxy-1-nitrobicyclo[5.4.0]undecan-9-one ( 13 ), and the medium-ring compounds 2-acetyl-4-nitrocyclooctanone ( 9 ), methyl 5-nitro-2-oxocyclooctane-carboxylate ( 4 ), 2-acetyl-4-nitrocyclononanone ( 11 ), 2-acetyl-4-nitrocyclodecanone ( 15 ), benzyl 5-nitro-2,11-dioxocycloundecanecarboxylate ( 24 ), methyl 5-nitro-2,12-dioxocyclododecanecarboxylate ( 21 ), and 8-nitro-11-oxo-13-tridecanolide ( 7 ), which are intermediates, side products, or end products of the ‘Zip’ ring-enlargement reaction. The conformations of most of the medium-ring compounds are very similar to equal-sized ring compounds previously determine by other authors.     

ESR study of spin-adducts of phosphoryl radicals with methano[60]fullerenes

The influence of structurally different methanofragments attached to [60]fullerene on the spectral parameters of the spin-adducts of phosphoryl radicals with these compounds was studied by ESR spectroscopy. The main direction of attack of phosphoryl radicals is the same fullerene hemisphere to which the methanofragment is attached. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya. No. 5, pp. 845–848, May, 2000.     

Synthese von Tetradecano-14-lacton durch Ringerweiterung

Synthesis of Tetradecano-14-lactone by Ring Enlargement The aldehyde 3 , prepared by ozonolysis of 2-allyl-2-nitrocyclododecanone, gave the ring-enlargement product 5 (85%) by treatment with (i-Bu)₂AlH. Its transformation to the tetradecano-14-lactone ( 8 ) via the aldol ester 6 and other routes (best is reduction with Bu₃SnH, AlBN, toluene) was difficult. Remarkable is the smooth denitrification of 3 (loss of HNO₂) to the conjugated dione 4 by chromatography on silica gel or base treatment.     

Determination of the rate constants of addition of.P(O)(OPri)2 radicals to fullerenes C60 and C70

The rate constants of the addition of phosphoryl radicals to fullerenes C₆₀ and C₇₀ were determined by the method of competitive reactions. The phosphoryl radicals were shown to be 1.5–3 orders of magnitude more reactive than the carbon-centered radicals. Published inIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1652–1655, September, 2000.     

Beta-spectroscopic separation of90Sr,90Y and89Sr with a scintillation detector

A -spectroscopic method for measurement of the isotope ratios and absolute activities of⁹⁰Sr,⁹⁰Y and⁸⁹Sr with an organic scintillator is described and tested. The correction factors for absorption in the sample and the detector window are calculated. The method can be used for rapid estimation of ratios and absolute activities of pure -emitters after a nuclear accident.Supported in part by the International Atomic Energy Agency, RC5633 and the National Fund for Scientific Research (Bulgaria).     

Analysis of HIV-1 fusion peptide inhibition by synthetic peptides from E1 protein of GB virus C

The aim of this study was to identify proteins that could inhibit the activity of the peptide sequence representing the N-terminal of the surface protein gp41 of HIV, corresponding to the fusion peptide of the virus (HIV-1 FP). To do this we synthesized and studied 58 peptides corresponding to the envelope protein E1 of the hepatitis G virus (GBV-C). Five of the E1 synthetic peptides: NCCAPEDIGFCLEGGCLV (P7), APEDIGFCLEGGCLVALG (P8), FCLEGGCLVALGCTICTD (P10), QAGLAVRPGKSAAQLVGE (P18) and AQLVGELGSLYGPLSVSA (P22) were capable of inhibiting the leakage of vesicular contents caused by HIV-1 FP. A series of experiments were carried out to determine how these E1 peptides interact with HIV-1 FP. Our studies analyzed the interactions with and without the presence of lipid membranes. Isothermal titration calorimetry revealed that the binding of P7, P18 and P22 peptides to HIV-1 FP is strongly endothermic, and that binding is entropy-driven. Gibbs energy for the process indicates a spontaneous binding between E1 peptides and HIV-1 FP. Moreover, confocal microscopy of Giant Unilamellar Vesicles revealed that the disruption of the lipid bilayer by HIV-1 FP alone was inhibited by the presence of any of the five selected peptides. Our results highlight that these E1 synthetic peptides could be involved in preventing the entry of HIV-1 by binding to the HIV-1 FP. Therefore, the continued study into the interaction between GBV-C peptides and HIV-1 FP could lead to the development of new therapeutic agents for the treatment of AIDS.     

Monotone-iterative method for mixed boundary value problems for generalized difference equations with “maxima”

In this paper the authors investigate special type of difference equations which involve both delays and the maximum value of the unknown function over a past time interval. This type of equations is used to model a real process which present state depends significantly on its maximal value over a past time interval. An appropriate mixed boundary value problem for the given nonlinear difference equation is set up. An algorithm, namely, the monotone iterative technique is suggested to solve this problem approximately. An important feature of our algorithm is that each successive approximation of the unknown solution is equal to the unique solution of an appropriately constructed initial value problem for a linear difference equation with “maxima”, and a formula for its explicit form is given. Also, each approximation is a lower/upper solution of the given nonlinear boundary value problem. Several numerical examples are considered to illustrate the practical application of the suggested algorithm.     

Effect of aging creep of polyestermalein resin/mineral filler composites

Long-term (More than 20 years) creep under compression of two polymer concretes, polyestermalein resin/mineral filler composites, was studied. The concretes differ with diabase filler size (d=5–10 mm and d=10–20 mm). It was shown that nonlinearity of viscoelastic properties of concrete increases as the size of filler particle decreases. Aging of the polymer concretes reduces their viscoelastic compliance and shortens the time interval necessary to reach equilibrium conditions under stable loading state.Presented at the Ninth International Conference on the Mechanics of Composite Materials, Riga, October, 1995.Institute of Theoretical and Applied Mechanics of the AS CR, Prague 9, Prosecká 74, Czech Republic. Central Laboratory of Physical-Chemical Mechanics of the BAS, Sofia 1113 Acad. Bontchev Street, IV km, Bl. 1. Published in Mekhanika Kompozitnykh Materialov, Vol. 32, No. 2, pp. 190–194, March–April, 1995.