Simultaneous determination of atractylenolide II and atractylenolide III by liquid chromatography-tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of Atractylodes Macrocephala Rhizoma extract

Atractylenolide II (AII) and atractylenolide III (AIII) are the major active components in Atractylodes Macrocephala Rhizoma (AMR). In this study, a sensitive, rapid and selective liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method was developed and validated for the simultaneous determination of AII and AIII in rat plasma using loliolide as internal standard (IS). After protein precipitation with ethyl acetate, the analytes were injected into an LC‐MS/MS system for quantification. Chromatography was performed using a C₁₈ column, eluting with water and acetonitrile (45:55, v/v) at 0.2 mL/min. All analytes including IS were monitored under positive ionization conditions by multiple reaction monitoring with an electrospray ionization source. The validated method was successfully applied to the pharmacokinetic study of AII and AIII in rat plasma after oral administration of AMR extract. The results provided a meaningful basis for evaluating the clinical applications of traditional Chinese medicine. Copyright © 2012 John Wiley & Sons, Ltd.     

表面极化对弱锚定向列液晶盒饱和特性的影响

以修正后的Rapini-Papoular锚定能公式为基础, 用理论分析和数值计算相结合的方法, 详细研究表面极化对液晶盒饱和特性的影响. 得出了求解指向矢分布的数学方程, 推导出了计算正常二级转变饱和电压的解析式, 同时结合最新报道, 给出了异常一级转变饱和电压的数值计算方法. 此外, 本文引入了反映指向矢分布特征的参量, 讨论了表面极化对此参量的影响. 结果表明, 指向矢最大倾角的位置随表面极化的增大将远离中央平面向基板移动. 一级转变饱和电压随弱锚定基板表面极化的增大而减小, 随强锚定基板表面极化的增大而增大. 而对二级转变, 饱和电压随表面极化的变化与一级转变恰恰相反. 本文所得结论对液晶表面物理的理解及液晶实际应用都具有重要的指导意义.     

高频原子波导中冷原子的磁导引

建立了高频原子波导模型,分析了铷冷原子在该波导内与磁场的相互作用势。高频波导线圈输入电流,在线圈中心轴线区域的势阱深度为mK量级,在线圈的径向能对温度为100 K左右的冷原子实现囚禁。通过分析可知改变输入波导线圈的输入电流大小,可改变势场的大小。计算了进入高频原子波导的冷原子和波导磁场产生相互作用束缚力的大小。在波导轴线中心区域,原子受到的束缚力较大,最大为1.710－23 N,为原子所受重力的10倍。     

Chaotification of complex networks with impulsive control

This paper investigates the chaotification problem of complex dynamical networks (CDN) with impulsive control. Both the discrete and continuous cases are studied. The method is presented to drive all states of every node in CDN to chaos. The proposed impulsive control strategy is effective for both the originally stable and unstable CDN. The upper bound of the impulse intervals for originally stable networks is derived. Finally, the effectiveness of the theoretical results is verified by numerical examples.     

Exploration of the sum of flexoelectric coef ficients of nematic liquid crystals

We present a theoretical calculation of the dependence of reflectivity Rpp of the improved fully leaky waveguide geometry,which comprises pyramid,matching fluid,and strongly anchored hybrid aligned nematic liquid crystal(NLC) cell on the internal angle.The calculation is based on the multi layer optical theory and the elastic theory of liquid crystals.For different sums of flexoelectric coefficients e11 and e33,the curve of Rpp moves a distance to the left or the right relative to the case of ignoring the flexoelectric effect and the distance of the movement varies with different flexoelectric coefficients.Consequently,the sum of flexoelectric coefficients can be explored by measuring the distance of the movement.     

Geometric phases in qubit-oscillator system beyond conventional rotating-wave approximation

In this work we investigated the geometric phases of a qubit-oscillator system beyond the conventional rotating- wave approximation. We find that in the limiting of weak coupling the results coincide with that obtained under rotating-wave approximation while there exists an increasing difference with the increase of coupling constant. It was shown that the geometric phase is symmetric with respect to the sign of the detuning of the quantized field from the one-photon resonance under the conventional rotating-wave approximation while a red-blue detuning asymmetry occurs beyond the conventional rotating-wave approximation.     

Analysis and optimization of a new photonic crystal filters in near ultraviolet band

Transmission characteristics of one-dimensional (1D) photonic crystals (PCs) heterostructures containing defective are studied using the transfer matrix method. The key is to search the best combination style for different 1D PCs to form heterostructures. It is shown that the non-transmission range over near ultraviolet and visible range can be substantially enlarged and the phenomenon of narrow band PC filter in near ultraviolet can be realized by adjusting the repeat cycle counts of various photonic crystals. The theoretical results on multiple heterostructures containing TiO₂/SiO₂ multilayer films are presented. With a perfect omni-directional and high peak transmission filters for TE modes, this structure opens a promising way to fabricate ultra-narrow band PC filters with wide non-transmission range in near ultraviolet and visible range.     

Bragg gratings in rectangular microfiber for temperature independent refractive index sensing

We present fiber Bragg grating fabricated in rectangular microfiber for temperature-independent refractive index (RI) measurement. The grating has two Bragg peaks due to the high geometrical birefringence of the rectangular microfiber. The two peaks present different RI responses because the modes along the orthogonal polarizations have different energy fractions in terms of evanescent field outside the silica microfiber and hence the light/liquid interaction strength are different. In contrast, they exhibit identical temperature sensitivities because most mode energy is confined in the microfiber and the thermal-optic effect of silica dominantly determines the temperature response. As a result, temperature-independent RI sensing can be realized by monitoring the wavelength separation between the two peaks.     

Noncontact all-optical measurement of corneal elasticity

We report on a noninvasive and noncontact all-optical method to measure the elasticity of the cornea. We use a pulsed laser to excite surface acoustic waves (SAW) that propagate on the corneal surface, then use a phase-sensitive optical coherence tomography system to remotely record the SAWs from which the corneal elasticity is estimated. In addition, the system is able to provide real-time tomographic images of the cornea being examined, an important consideration for clinical studies. While precisely maintaining a range of intraocular pressures (IOP), a series of measurements is performed on ex vivo intact primate eyes. The measurement results not only demonstrate the feasibility of the proposed system to remotely measure the corneal elasticity, but also suggest a strong correlation between the corneal stiffness and the true IOP.     

电流主动导引结构倒装AlGaInP LED

设计并制备了一种带有电流导引结构的新型倒装AlGaInP LED。实验结果表明,在20mA直流电流注入下,器件的电压为2.19V,输出光功率与普通倒装器件相比提高了17.33%。通过电流导引结构,使得器件注入电流被主动引导到电极以外部分,有效增大了上电极以外部分有源区中用于发光的有效载流子数目的比例,同时减轻了电流密度过大现象,大大提高了器件的出光效率。