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861.
Jayachandran Jayakumar Kanniyappan Parthasarathy Yi‐Hsiang Chen Tai‐Hua Lee Shih‐Ching Chuang Chien‐Hong Cheng 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2014,126(37):10047-10050
A new method for the synthesis of highly substituted naphthyridine‐based polyheteroaromatic compounds in high yields proceeds through rhodium(III)‐catalyzed multiple C H bond cleavage and C C and C N bond formation in a one‐pot process. Such highly substituted polyheteroaromatic compounds have attracted much attention because of their unique π‐conjugation, which make them suitable materials for organic semiconductors and luminescent materials. Furthermore, a possible mechanism, which involves multiple chelation‐assisted ortho C H activation, alkyne insertion, and reductive elimination, is proposed for this transformation. 相似文献
862.
A convenient and regioselective one-pot synthesis of 3-chloride or 3-bromide quinoline derivatives was achieved through a Grignard addition reaction by alkynyl Grignard regent to o-trifluoroacetyl aniline and a Cu(II)-catalyzed cyclization–halogenation tandem reaction with aqueous HCl or HBr as electrophilic reagent. 相似文献
863.
Wen Zhou Xiao-Li Sun Lin Gu Fei-Fei Bao Xin-Xin Xu Chun-Yan Pang Zhi-Guo Gu Zaijun Li 《Journal of Radioanalytical and Nuclear Chemistry》2014,300(2):843-852
Three new mesoporous silica materials IL15SGs (HF15SG, TF15SG and DF15SG) doped with benzo-15-crown-5 and imidazolium based ionic liquids (C8mim+PF6 ?, C8mim+BF4 ? or C8mim+NTf 2 ? ) have been prepared by a simple approach to separating lithium isotopes. The formed mesoporous structures of silica gels have been confirmed by transmission electron microscopy image and N2 gas adsorption–desorption isotherm. Imidazolium ionic liquids acted as templates to prepare mesoporous materials, additives to stabilize extractant within silica gel, and synergetic agents to separate the lithium isotopes. Factors such as lithium salt concentration, initial pH, counter anion of lithium salt, extraction time, and temperature on the lithium isotopes separation were examined. Under optimized conditions, the extraction efficiency of HF15SG, TF15SG and DF15SG were found to be 11.43, 10.59 and 13.07 %, respectively. The heavier isotope 7Li was concentrated in the solution phase while the lighter isotope 6Li was enriched in the gel phase. The solid–liquid extraction maximum single-stage isotopes separation factor of 6Li–7Li in the solid–liquid extraction was up to 1.046 ± 0.002. X-ray crystal structure analysis indicated that the lithium salt was extracted into the solid phase with crown ether forming [(Li0.5)2(B15)2(H2O)]+ complexes. IL15SGs were also easily regenerated by stripping with 20 mmol L?1 HCl and reused in the consecutive removal of lithium ion in five cycles. 相似文献
864.
Ariane Wohlfarth Adarsh S. Gandhi Shaokun Pang Mingshe Zhu Karl B. Scheidweiler Marilyn A. Huestis 《Analytical and bioanalytical chemistry》2014,406(6):1763-1780
Background
PB-22 (1-pentyl-8-quinolinyl ester-1H-indole-3-carboxylic acid) and 5F-PB-22 (1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid) are new synthetic cannabinoids with a quinoline substructure and the first marketed substances with an ester bond linkage. No human metabolism data are currently available, making it difficult to document PB-22 and 5F-PB-22 intake from urine analysis, and complicating assessment of the drugs’ pharmacodynamic and toxicological properties.Methods
We incubated 10 μmol/l PB-22 and 5F-PB-22 with pooled cryopreserved human hepatocytes up to 3 h and analyzed samples on a TripleTOF 5600+ high-resolution mass spectrometer. Data were acquired via TOF scan, followed by information-dependent acquisition triggered product ion scans with mass defect filtering (MDF). The accurate mass full scan MS and MS/MS metabolite datasets were analyzed with multiple data processing techniques, including MDF, neutral loss and product ion filtering.Results
The predominant metabolic pathway for PB-22 and 5F-PB-22 was ester hydrolysis yielding a wide variety of (5-fluoro)pentylindole-3-carboxylic acid metabolites. Twenty metabolites for PB-22 and 22 metabolites for 5F-PB-22 were identified, with the majority generated by oxidation with or without glucuronidation. For 5F-PB-22, oxidative defluorination occurred forming PB-22 metabolites. Both compounds underwent epoxide formation followed by internal hydrolysis and also produced a cysteine conjugate.Conclusion
Human hepatic metabolic profiles were generated for PB-22 and 5F-PB-22. Pentylindole-3-carboxylic acid, hydroxypentyl-PB-22 and PB-22 pentanoic acid for PB-22, and 5′-fluoropentylindole-3-carboxylic acid, PB-22 pentanoic acid and the hydroxy-5F-PB-22 metabolite with oxidation at the quinoline system for 5F-PB-22 are likely the best targets to incorporate into analytical methods for urine to document PB-22 and 5F-PB-22 intake.Metabolism of synthetic cannabinoids PB-22 and 5F-PB-22 by human hepatocyte incubation and high-resolution mass spectrometry 相似文献
865.
Lihong Lin Wei Yu Yanan Pang Changsong Sun Qinghe Meng Xiaolei Li Xingjie Guo 《Analytical and bioanalytical chemistry》2014,406(22):5521-5526
A simple, sensitive, and reliable liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed for determination of pyraoxystrobin in rat plasma and applied to a toxicokinetics study. The separation was performed by gradient elution on a Luna 5 μ C18 (2) 100 Å column (50?×?4.6 mm I.D., 5 μm) with mobile phase: water (0.1 % formic acid, v/v)/acetonitrile (0.1 % formic acid, v/v), followed by quantification with a mass detector in multiple reaction monitoring (MRM) mode using ESI as an interface. The calibration curve was linear over a concentration range of 1.00–200 ng/mL. The recovery for pyraoxystrobin ranged from 101.4 to 108.2 %. The intraday bias and precision ranged from ?9.3 to 8.1 % and from 0.7 to 8.4 %, respectively, and the interday bias and precision ranged from ?0.3 to 4.0 % and from 4.4 to 7.2 %, respectively. The toxicokinetics of pyraoxystrobin after single 100 and 1,000 mg/kg oral doses were studied in rats. Figure
The chromatogram of pyraoxystrobin highest calibration standard (ULOQ) extract. 相似文献
866.
运用分子动力学模拟,研究了腺苷酸(激动剂)与A2AAR腺苷受体蛋白的相互作用和配体结合诱导的蛋白动力学变化.识别了与腺苷酸结合力强于0.5kcal/mol的关键基团:A63^2.61,I66^2.64,V84^3.32,L85^3.33,T88^3.36,F168^5.29,M177^5.38,L249^6.51,H250^6.52和N253^6.55,观察到腺苷酸没有与L167^5.28相互作用,这一结果支持了L167^5.28是抑制剂特异性结合位点,不与激动剂结合.未结合配体(激动剂或抑制剂)的单体A2AAR和腺苷酸结合后的A2AAR在构象上有三个不同功能性开关.腺苷酸结合可以诱导A2AAR腺苷受体蛋白的构象调整,使得三个功能性开关器件的构象与单体A2AAR不同. 相似文献
867.
In Situ Facile Synthesis of Ru‐Based Core–Shell Nanoparticles Supported on Carbon Black and Their High Catalytic Activity in the Dehydrogenation of Amine‐Boranes
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Well‐dispersed core–shell Ru@M (M=Co, Ni, Fe) nanoparticles (NPs) supported on carbon black have been synthesized via a facile in situ one‐step procedure under ambient condition. Core‐shell Ru@Co NPs were synthesized and characterized for the first time. The as‐synthesized Ru@Co and Ru@Ni NPs exhibit superior catalytic activity in the hydrolysis of ammonia borane compared with their monometallic and alloy counterparts. The Ru@Co/C NPs are the most reactive, with a turnover frequency (TOF) value of 320 (mol min?1) molRu?1 and activation energy (Ea) of 21.16 kJ mol?1. Ru@Ni/C NPs are the next most active, whereas Ru@Fe/C NPs are almost inactive. Additionally, the as‐synthesized NPs supported on carbon black exhibit higher catalytic activity than catalysts on other conventional supports, such as SiO2 and γ‐Al2O3. 相似文献
868.
Rongmei Si Dr. Li Wei Dr. Hong Wang Dingdian Su Prof. Samir H. Mushrif Prof. Yuan Chen 《化学:亚洲杂志》2014,9(3):868-877
Selective polymer wrapping is a promising approach to obtain high‐chiral‐purity single‐walled carbon nanotubes (SWCNTs) needed in technical applications and scientific studies. We showed that among three fluorene‐based polymers with different side‐chain lengths and backbones, poly[(9,9‐dihexylfluorenyl‐2,7‐diyl)‐co‐(9,10‐anthracene)] (PFH‐A) can selectively extract SWCNTs synthesized from the CoSO4/SiO2 catalyst, which results in enrichment of 78.3 % (9,8) and 12.2 % (9,7) nanotubes among all semiconducting species. These high‐chiral‐purity SWCNTs may find potential applications in electronics, optoelectronics, and photovoltaics. Furthermore, molecular dynamics simulations suggest that the extraction selectivity of PFH‐A relates to the bending and alignment of its alkyl chains and the twisting of its two aromatic backbone units (biphenyl and anthracene) relative to SWCNTs. The strong π–π interaction between polymers and SWCNTs would increase the extraction yield, but it is not beneficial for chiral selectivity. Our findings suggest that the matching between the curvature of SWCNTs and the flexibility of the polymer side chains and the aromatic backbone units is essential in designing novel polymers for selective extraction of (n,m) species. 相似文献
869.
Dr. Wei Liu Dr. Qiu‐Han Lin Dr. Yu‐Zhang Yang Dr. Xue‐Jiao Zhang Prof. Yu‐Chuan Li Dr. Zhi‐Hui Lin Prof. Si‐Ping Pang 《化学:亚洲杂志》2014,9(2):479-486
A family of energetic salts with high thermal stability and low impact sensitivity based on an oxygen‐containing cation, 2,4‐diamino‐1,3,5‐triazine‐6‐one, were synthesized and fully characterized by IR and multinuclear (1H, 13C) NMR spectroscopy, elemental analysis, and differential scanning calorimetry. Insights into their sensitivities towards impact, friction, and electrostatics were gained by submitting the materials to standard tests. The structures of 2,4‐diamino‐1,3,5‐triazine‐6‐one nitrate, 2,4‐diamino‐1,3,5‐triazine‐6‐one sulfate, 2,4‐diamino‐1,3,5‐triazine‐6‐one perchlorate, 2,4‐diamino‐1,3,5‐triazine‐6‐one 5‐nitrotetrazolate were determined by single‐crystal X‐ray diffraction; their densities are 1.691, 1.776, 1.854, and 1.636 g cm?3, respectively. Most of the salts decompose at temperatures over 180 °C; in particular, the salts 2,4‐diamino‐1,3,5‐triazine‐6‐one nitrate and 2,4‐diamino‐1,3,5‐triazine‐6‐one perchlorate, which decompose at 303.3 and 336.4 °C, respectively, are fairly stable. Furthermore, most of the salts exhibit excellent impact sensitivities (>40 J), friction sensitivities (>360 N), and are insensitive to electrostatics. The measured densities of these energetic salts range from 1.64 to 2.01 g cm?3. The detonation pressure values calculated for these salts range from 14.6 to 29.2 GPa, and the detonation velocities range from 6536 to 8275 m s?1; these values make the salts potential candidates for thermally stable and insensitive energetic materials. 相似文献
870.
Hong Shen 《Acta Crystallographica. Section C, Structural Chemistry》2014,70(11):1025-1028
The title CdII coordination polymer, [Cd(C10H8O4)(C12H12N6)0.5(H2O)]n, has been obtained by the hydrothermal method and studied by single‐crystal X‐ray diffraction, elemental analysis, thermogravimetric analysis, IR spectroscopy and fluorescence spectroscopy. The compound forms a novel three‐dimensional framework with 3,8‐connected three‐dimensional binodal {4.52}2{42.510.612.7.83} topology. An investigation of its photoluminescence properties shows that the compound exhibits a strong fluorescence emission in the solid state at room temperature. 相似文献