全文获取类型
收费全文 | 128篇 |
免费 | 9篇 |
国内免费 | 1篇 |
专业分类
化学 | 104篇 |
晶体学 | 2篇 |
力学 | 1篇 |
数学 | 18篇 |
物理学 | 13篇 |
出版年
2023年 | 4篇 |
2022年 | 3篇 |
2021年 | 4篇 |
2020年 | 5篇 |
2019年 | 3篇 |
2018年 | 2篇 |
2017年 | 5篇 |
2016年 | 8篇 |
2015年 | 7篇 |
2014年 | 6篇 |
2013年 | 8篇 |
2012年 | 19篇 |
2011年 | 5篇 |
2010年 | 8篇 |
2009年 | 8篇 |
2008年 | 12篇 |
2007年 | 8篇 |
2006年 | 4篇 |
2005年 | 4篇 |
2004年 | 3篇 |
2003年 | 1篇 |
2002年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1992年 | 2篇 |
1986年 | 1篇 |
1981年 | 1篇 |
1977年 | 2篇 |
1976年 | 1篇 |
排序方式: 共有138条查询结果,搜索用时 161 毫秒
91.
High pressure thermal (HPT) processing is a candidate technology for the production of safe and stable food. However, little is known about the effect of HPT or high hydrostatic pressure (HHP) treatments at ambient temperature on the variability of times to detect growth from individual spores. We investigated this effect by treating Clostridium botulinum type E spores with HHP (200–600?MPa, 20°C) and HPT (600?MPa, 80°C and 800?MPa, 60°C). Our results indicate that the mean detection times increase and the frequency distribution shifts toward longer times when HHP treatment intensity is increased. HPT treatments result in a highly scattered distribution. In contrast, pressure levels ≤300?MPa decrease detection times and heterogeneity of their distribution, which could lead to an increase in the potential risk originating from C. botulinum type E spores. Data provided here could help to refine risk assessment regarding this important food intoxicator. 相似文献
92.
Michael A. Stravs Emma L. Schymanski Heinz P. Singer Juliane Hollender 《Journal of mass spectrometry : JMS》2013,48(1):89-99
High accuracy, high resolution tandem mass spectrometry (MS/MS) is becoming more common in analytical applications, yet databases of these spectra remain limited. Databases require good quality spectra with sufficient compound information, but processing, calibration, noise reduction and retrieval of compound information are time‐consuming tasks that prevent many contributions. We present a comprehensive workflow for the automatic processing of MS/MS using formula annotation for recalibration and cleanup to generate high quality spectra of standard compounds for upload to MassBank ( www.massbank.jp ). Compound information is retrieved via Internet services. Reference standards of 70 pesticides were measured at various collision energies on an LTQ‐Orbitrap XL to develop and evaluate the workflow. A total of 944 resulting spectra are now available on MassBank. Evidence of nitrogen adduct formation during MS/MS fragmentation processes was found, highlighting the benefits high accuracy MS/MS offers for spectral interpretation. A database of recalibrated, cleaned‐up spectra resulted in the most correct spectra ranked in first place, regardless of whether the search spectra were recalibrated or not, whereas the average rank of the correct molecular formula was improved from 2.55 (uncalibrated) to 1.53 when using recalibrated MS/MS data. The workflow is available as an R package RMassBank capable of generating MassBank records from raw MS and MS/MS data and can be adjusted to process data acquired with different settings and instruments. This workflow is a vital step towards addressing the need for more high quality, high accuracy MS/MS spectra in spectral databases and provides important information for spectral interpretation. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
93.
Stephanie Spahr Sebastian Huntscha Jakov Bolotin Michael P. Maier Martin Elsner Juliane Hollender Thomas B. Hofstetter 《Analytical and bioanalytical chemistry》2013,405(9):2843-2856
Compound-specific isotope analysis (CSIA) is an important tool for the identification of contaminant sources and transformation pathways, but it is rarely applied to emerging aquatic micropollutants owing to a series of instrumental challenges. Using four different benzotriazole corrosion inhibitors and its derivatives as examples, we obtained evidence that formation of organometallic complexes of benzotriazoles with parts of the instrumentation impedes isotope analysis. Therefore, we propose two strategies for accurate $\delta^{13}$ C and $\delta^{15}$ N measurements of polar organic micropollutants by gas chromatography isotope ratio mass spectrometry (GC/IRMS). Our first approach avoids metallic components and uses a Ni/Pt reactor for benzotriazole combustion while the second is based on the coupling of online methylation to the established GC/IRMS setup. Method detection limits for on-column injection of benzotriazole, as well as its 1-CH $_{3}$ -, 4-CH $_{3}$ -, and 5-CH $_{3}$ -substituted species were 0.1–0.3 mM and 0.1–1.0 mM for δ13C and δ15N analysis respectively, corresponding to injected masses of 0.7–1.8 nmol C and 0.4–3.0 nmol N, respectively. The Ni/Pt reactor showed good precision and was very long-lived ( $>$ 1000 successful measurements). Coupling isotopic analysis to offline solid-phase extraction enabled benzotriazole-CSIA in tap water, wastewater treatment effluent, activated sludge, and in commercial dishwashing products. A comparison of $\delta ^{13}$ C and $\delta ^{15}$ N values from different benzotriazoles and benzotriazole derivatives, both from commercial standards and in dishwashing detergents, reveals the potential application of the proposed method for source apportionment. 相似文献
94.
Mixture surrogate models based on Dempster-Shafer theory for global optimization problems 总被引:2,自引:0,他引:2
Recent research in algorithms for solving global optimization problems using response surface methodology has shown that it
is in general not possible to use one surrogate model for solving different kinds of problems. In this paper the approach
of applying Dempster-Shafer theory to surrogate model selection and their combination is described. Various conflict redistribution
rules have been examined with respect to their influence on the results. Furthermore, the implications of the surrogate model
type, i.e. using combined, single or a hybrid of both, have been studied. The suggested algorithms were applied to several
well-known global optimization test problems. The results indicate that the used approach leads for all problems to a thorough
exploration of the variable domain, i.e. the vicinities of global optima could be detected, and that the global minima could
in most cases be approximated with high accuracy. 相似文献
95.
Tams Kiss Tams Jakusch Dominik Hollender gnes Drnyei va A. Enyedy Joo Costa Pessoa Hiromu Sakurai Alfredo Sanz-Medel 《Coordination chemistry reviews》2008,252(10-11):1153
The possible transformations of antidiabetic vanadium(IV) complexes in the organism are discussed. These reactions involve absorption processes in the gastrointestinal tract, transport in the blood stream and interactions with endogenous binding molecules in the glucose-metabolizing cells. Modeling studies were mostly used to determine the actual chemical form of VO(IV) complexes in various biological environments. The results suggest that decomposition and subsequent ternary complex formation with endogenous or exogenous ligands in the organism affects the absorption efficacy of the originally neutral VO(IV) compounds considerably. During transport in the blood stream, transferrin displaces the carrier ligands from the VO(IV) compounds and plays an important role in transporting VO(IV) to the cell. In the cell, vanadium undergoes redox interaction with glutathione and complexation with adenosine 5′-triphosphate (the two important cell components present in mM concentration). In vitro and in vivo biological results confirmed some of the basic findings obtained from the modeling. 相似文献
96.
Skrabania K Kristen J Laschewsky A Akdemir O Hoth A Lutz JF 《Langmuir : the ACS journal of surfaces and colloids》2007,23(1):84-93
Nonionic water-soluble poly(acrylamide)s and poly(acrylate)s were synthesized by RAFT and ATRP methods. Similar to the synthesized poly(N-isopropylacrylamide) and poly(N-acryloylpyrrolidine), aqueous solutions of statistical acrylate copolymers bearing two different oligo(ethylene oxide) side chains showed a sharp clouding transition upon heating beyond characteristic temperatures. The temperature of the cloud point can be easily fine tuned by the copolymer composition. As for poly(N-isopropylacrylamide) and poly(N-acryloylpyrrolidine), the cloud-point temperatures of these statistical copolymers are rather insensitive to changes in the molar mass or the NaCl content of the solutions. Also, ternary triblock copolymers containing one permanently hydrophilic block and two different thermoresponsive blocks were synthesized, varying the block sequence systematically. Their aggregation in aqueous solution was followed by turbidimetry and dynamic light scattering. Depending on the heating process and the triblock sequence, micellar aggregates of 40 to 600 nm size were found. The thermally induced aggregation behavior depends sensitively on the block sequence but is also subject to major kinetic effects. For certain block sequences, a thermally induced two-step association is observed when heating beyond the first and second cloud points of the thermoresponsive blocks. However, the thermal-transition temperatures of the block polymers can differ from the thermal-transition temperatures of the individual homopolymers. This may be caused by end-group effects but also by mutual interactions of the different blocks in solution, as physical mixtures of the homopolymers exhibit deviations from a purely additive thermal behavior. 相似文献
97.
Suspect and nontarget screening approaches to identify organic contaminant records in lake sediments
Aurea C. Chiaia-Hernandez Emma L. Schymanski Praveen Kumar Heinz P. Singer Juliane Hollender 《Analytical and bioanalytical chemistry》2014,406(28):7323-7335
Sediment cores provide a valuable record of historical contamination, but so far, new analytical techniques such as high-resolution mass spectrometry (HRMS) have not yet been applied to extend target screening to the detection of unknown contaminants for this complex matrix. Here, a combination of target, suspect, and nontarget screening using liquid chromatography (LC)-HRMS/MS was performed on extracts from sediment cores obtained from Lake Greifensee and Lake Lugano located in the north and south of Switzerland, respectively. A suspect list was compiled from consumption data and refined using the expected method coverage and a combination of automated and manual filters on the resulting measured data. Nontarget identification efforts were focused on masses with Cl and Br isotope information available that exhibited mass defects outside the sample matrix, to reduce the effect of analytical interferences. In silico methods combining the software MOLGEN-MS/MS and MetFrag were used for direct elucidation, with additional consideration of retention time/partitioning information and the number of references for a given substance. The combination of all available information resulted in the successful identification of three suspect (chlorophene, flufenamic acid, lufenuron) and two nontarget compounds (hexachlorophene, flucofuron), confirmed with reference standards, as well as the tentative identification of two chlorophene congeners (dichlorophene, bromochlorophene) that exhibited similar time trends through the sediment cores. This study demonstrates that complementary application of target, suspect, and nontarget screening can deliver valuable information despite the matrix complexity and provide records of historical contamination in two Swiss lakes with previously unreported compounds. 相似文献
98.
Emma L. Schymanski Heinz P. Singer Jaroslav Slobodnik Ildiko M. Ipolyi Peter Oswald Martin Krauss Tobias Schulze Peter Haglund Thomas Letzel Sylvia Grosse Nikolaos S. Thomaidis Anna Bletsou Christian Zwiener María Ibáñez Tania Portolés Ronald de Boer Malcolm J. Reid Matthias Onghena Uwe Kunkel Wolfgang Schulz Amélie Guillon Naïke Noyon Gaëla Leroy Philippe Bados Sara Bogialli Draženka Stipaničev Pawel Rostkowski Juliane Hollender 《Analytical and bioanalytical chemistry》2015,407(21):6237-6255
99.
Dr. Patrik Neuhaus Dr. Arjen Cnossen Juliane Q. Gong Prof. Laura M. Herz Prof. Harry L. Anderson 《Angewandte Chemie (International ed. in English)》2015,54(25):7344-7348
A π‐conjugated twelve‐porphyrin tube is synthesized in 32 % yield by a template‐directed coupling reaction that joins together six porphyrin dimers, forming twelve new C? C bonds. The nanotube has two bound templates, enclosing an internal volume of approximately 4.5 nm3. Its UV/Vis/NIR absorption and fluorescence spectra resemble those of a previously reported six‐porphyrin ring, but are red‐shifted by approximately 300 cm?1, reflecting increased conjugation. Ultrafast fluorescence spectroscopy demonstrates extensive excited‐state delocalization. Transfer of electronic excitation from an initially formed state polarized in the direction of the nanotube axis (z axis) to an excited state polarized in the xy plane occurs within 200 fs, resulting in a negative fluorescence anisotropy on excitation at 742 nm. 相似文献
100.
Bert De Rybel Dominique Audenaert Grégory Vert Wilfried Rozhon Juliane Mayerhofer Frank Peelman Silvie Coutuer Tinneke Denayer Leentje Jansen Long Nguyen Isabelle Vanhoutte Gerrit T.S. Beemster Kris Vleminckx Claudia Jonak Joanne Chory Dirk Inzé Eugenia Russinova Tom Beeckman 《Chemistry & biology》2009,16(6):594-604