Structure–activity relationship of polyamine conjugates for uptake via polyamine transport system

Structural Chemistry - High toxicity of anticancer drugs led to development of targeted drug delivery directly to the specific organs. Polyamine transport system (PTS) of mammalian cells is one of...     

Experimental and computational studies of trifluoromethylation of aromatic amines by the system trifluoroiodomethane-zinc-sulfur dioxide

Several trifluoromethyl-substituted aromatic and heteroaromatic amines have been obtained by the reactions of the corresponding amines with the title reagent system. Computational results provide rationalization for the observed regioselectivities and support a mechanism in which the electrophilic trifluoromethyl radicals interact with the aromatic ring at the sites with the greatest electron density of the HOMO orbitals, and then the resultant adducts are oxidized to cations. The products obtained are potential building blocks for a number of heterocyclic systems.     

Fabrication and characterization chitosan/functionalized zinc oxide bionanocomposites and study of their antibacterial activity

This study deals with preparation and evaluation of properties of chitosan/zinc oxide bionanocomposites (CT/ZnO BNCs) with different amounts of modified zinc oxide nanoparticles (ZnO NPs) through ultrasonic irradiation technique. Due to the high surface energy and tendency for agglomeration, the surface ZnO NPs was modified by a coupling agent as 3-aminopropyltriethoxysilane (APS) to form APS–ZnO nanoparticles. Fourier transform infrared (FTIR) spectroscopy confirmed that APS was successfully grafted onto the ZnO nanoparticles surface. Thermogravimetric analysis (TGA) revealed a surface coverage of the coupling molecule of 2.6 wt%. The resulting bionanocomposites were characterized by FTIR spectra, X-ray diffraction patterns, and TGA. The antibacterial activity of bionanocomposite films was tested against gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). The results of CT/ZnO BNCs revealed that the thermal and antibacterial properties obviously improved the presence of ZnO NPs in comparison with the pure CT and that this increase is higher when the NP content increases. Further, it was observed that antibacterial activity of the resulting hybrid biofilms showed somewhat higher for gram-positive bacteria compared to gram-negative bacteria.     

Highly stable asymmetric supercapacitors based on Ni(OH)<Subscript>2</Subscript> deposited on electro-etched carbon paper

Herein, we introduce the application of nickel hydroxide nanosheets on the electro-etched carbon fiber (ECF) formed via a direct electrodeposition, for fabrication of asymmetric supercapacitor. To confirm the practical applicability of prepared Ni(OH)₂–ECF, an asymmetric device was assembled using Ni(OH)₂–ECF in combination with an activated carbon (AC) electrode. Our results showed a substantial cycling stability (96% capacitance retention after 10000 cycles) and considerable rate capability at large discharge currents (60% capacitance retention at 8 A g^??1) for this asymmetric supercapacitor that may have originated from the good contact between Ni(OH)₂ and ECF. A maximum specific capacitance of 88.1 F g^??1 was achieved for Ni(OH)₂–ECF//AC/CF device and showed considerable rate capability at large discharge currents (60% capacitance retention at 8 A g^??1). The results of this study suggest the Ni(OH)₂–ECF electrode is an excellent material for fabrication of supercapacitor electrodes.     

Historical review of pharmacological development and dosimetry of PSMA-based theranostics for prostate cancer

Journal of Radioanalytical and Nuclear Chemistry - Many efforts have been made to introduce an appropriate radiopharmaceutical as a theranostic agent for metastatic castration-resistant prostate...     

Simultaneous Abel equations

Let S{\mathcal{S}} be a set of homeomorphisms of an open interval such that the group generated by S{\mathcal{S}} is disjoint, i.e., the graphs of any two distinct functions in it do not intersect. We give necessary and sufficient conditions for the system of Abel equations

A novel fabrication technique to minimize poly(dimethylsiloxane)‐microchannels deformation under high‐pressure operation

PDMS is one of the most common materials used for the flow delivery in the microfluidics chips, since it is clear, inert, nontoxic, and nonflammable. Its inexpensiveness, straightforward fabrication, and biological compatibility have made it a favorite material in the exploratory stages of the bio‐microfluidic devices. If small footprint assays want to be performed while keeping the throughput, high pressure‐rated channels should be used, but PDMS flexibility causes an important issue since it can generate a large variation of microchannel geometry. In this work, a novel fabrication technique based on the prevention of PDMS deformation is developed. A photo‐sensible thiolene resin (Norland Optical Adhesive 63, NOA 63) is used to create a rigid coating layer over the stiff PDMS micropillar array, which significantly reduces the pressure‐induced shape changes. This method uses the exact same soft lithography manufacturing equipment. The verification of the presented technique was investigated experimentally and numerically and the manufactured samples showed a deformation 70% lower than PDMS conventional samples.     

Cyclotron production of <Superscript>169</Superscript>Yb: a potential radiolanthanide for brachytherapy

In the present study, ytterbium-169 was produced via the ¹⁶⁹Tm(p, n)¹⁶⁹Yb nuclear process at the AMIRS (Cyclone-30, IBA, Belgium) cyclotron, irradiating Tm₂O₃ with proton particles of 15 MeV primary energy and 20 μA current for 20 min. Deposition of Tm₂O₃ on Cu substrate was carried out via by the sedimentation method. The 543 mg of thulium(III)oxide with 108 mg of ethyl cellulose and 8 mL of acetone were used to prepare a Tm₂O₃ layer of 11.69 cm². Yields of about 0.643 MBq ¹⁶⁹Yb per μAh were experimentally obtained. ¹⁶⁹Yb was separated in 80 ± 5% radiochemical yield using liquid–liquid extraction. Solvent extraction of no-carrier-added ¹⁶⁹Yb from irradiated thulium(III)oxide target hydrochloric solution was investigated using di-(2-ethylhexyl)phosphoric acid (HDEHP).