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51.
Total Synthesis of cis‐Clavicipitic Acid from Asparagine via Ir‐Catalyzed CH bond Activation as a Key Step
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Yu‐ki Tahara Mamoru Ito Dr. Kyalo Stephen Kanyiva Prof. Dr. Takanori Shibata 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(32):11340-11343
4‐Substituted tryptophan derivatives and the total synthesis of cis‐clavicipitic acid were achieved in reactions in which Ir‐catalyzed C?H bond activation was a key step. The starting material for these reactions is asparagine, which is a cheap natural amino acid. The reductive amination step from the 4‐substituted tryptophan derivative gave cis‐clavicipitic acid with perfect diastereoselectivity. 相似文献
52.
Youhei Sohma Hitomi KitamuraHiroyuki Kawashima Hironobu HojoMasayuki Yamashita Kenichi AkajiYoshiaki Kiso 《Tetrahedron letters》2011,52(52):7146-7148
By using dimethylformamide to suppress the O-to-N acyl migration, we efficiently synthesized an O-acyl isopeptide by native chemical ligation of a peptide-thioester and a Cys-O-acyl isopeptide. The reaction mixture was then loaded onto an octadecylsilane reverse-phase HPLC column, and the isopeptide was purified by using a linear gradient of CH3CN in 0.1% aqueous trifluoroacetic acid. The recovery rate of the O-acyl isopeptide was considerably higher than that of the corresponding native polypeptide. Synthesis of O-acyl isopeptides via native chemical ligation, with O-to-N acyl migration as the final step to give the native form, has potential as an efficient method of constructing hydrophobic polypeptides. 相似文献
53.
Pinyarat Jindaratsamee Yusuke Shimoyama Hironobu Morizaki Akira Ito 《The Journal of chemical thermodynamics》2011,43(3):311-314
The permeability of carbon dioxide (CO2) through imidazolium-based ionic liquid membranes was measured by a sweep gas method. Six species of ionic liquids were studied in this work as follows: [emim][BF4], [bmim][BF4], [bmim][PF6], [bmim][Tf2N], [bmim][OTf], and [bmim][dca]. The ionic liquids were supported with a polyvinylidene fluoride porous membrane. The measurements were performed at T = (303.15 to 343.15) K. The partial pressure difference between feed and permeate sides was 0.121 MPa. The permeability of the CO2 increases with temperature for the all ionic liquid species. Base on solution diffusion theory, it can be explained that the diffusion coefficient of CO2 in an ionic liquid affects the temperature dependence more strongly than the solubility coefficient. The greatest permeability was obtained with the [bmim][Tf2N] membrane. The membrane of [bmim][PF6] presents the lowest permeability.The separation coefficient between CO2 and N2 through the ionic liquid membranes was also investigated at the volume fraction of CO2 at feed side 0.10. The separation coefficient decreases with the increase of temperature for the all ionic liquid species. The membrane of [emim][BF4] and [bmim][BF4] gives the highest separation coefficient at constant temperature. The lowest separation coefficient was obtained from [bmim][Tf2N] membrane which presents the highest permeability of CO2. 相似文献
54.
Yatsukawa Y Ito H Matsuda T Nakamura M Watai M Fujita K 《Journal of AOAC International》2011,94(4):1319-1327
A new analytical method for the simultaneous determination of seven fluoroquinolones, namely, norfloxacin, ciprofloxacin, danofloxacin, enrofloxacin, orbifloxacin, sarafloxacin, and difloxacin, especially in dark-colored honey, has been developed. Fluoroquinolone antibiotics were extracted from samples with MacIlvaine buffer solution (pH 4.0) containing EDTA disodium salt dihydrate. The extracts were treated with both a polymeric cartridge and a metal chelate affinity column preloaded with ferric ion (Fe3+). LC separation with fluorescence detection was performed at 40 degrees C using an Inertsil ODS-4 analytical column (150 x 4.6 mm, 3 microm). The mobile phase was composed of 20 mM/L citrate buffer solution (pH 3.1)-acetonitrile mixture (70 + 30, v/v) containing 1 mM/L sodium dodecyl sulfate. Lomefloxacin was used as an internal standard. The developed method was validated according to the criteria of European Commission Decision 2002/657/EC. Decision limits and detection capabilities were below 2.9 and 4.4 microg/kg, respectively. 相似文献
55.
Shirakawa S Liu K Ito H Maruoka K 《Chemical communications (Cambridge, England)》2011,47(5):1515-1517
Efficient catalytic asymmetric synthesis of 1,1-disubstituted tetrahydro-β-carbolines has been achieved via asymmetric alkylation of 1-cyanotetrahydro-β-carbolines using a binaphthyl-modified N-spiro-type chiral phase-transfer catalyst. This is a valuable example of hitherto difficult highly enantioselective alkylations at α-carbon of the cyano group under phase-transfer conditions. 相似文献
56.
Vitamin B12-hyperbranched polymer was synthesized and characterized by UV-vis and NMR spectroscopy as well as DLS. The shape of hybrid polymer was also directly observed by TEM. Microenvironmental polarity around vitamin B12 derivative on the polymer was evaluated by UV-vis absorption peak with α-band of vitamin B12 chromophore. 相似文献
57.
Kayoko Tahara Emi Makii Shiro Iijima Yoshihiro Abe Masataka Mochizuki 《Analytical sciences》2008,24(7):935-938
The electrochemical oxidation of (+/-)-alpha-tocopherol on a porous graphite electrode was performed in the presence of methanol, and successive separation and detection of the products were performed by an on-line liquid chromatography/mass spectrometry system. Three products were identified, one of which was determined to be alpha-tocopheryl quinone, because its m/z was 469 [M+Na](+). The other two products showed identical mass and UV spectra, and were suspected to be diastereomers of 9-methoxy-alpha-tocopheron, because their molecular weights were m/z 483 [M+Na](+), and also because it is known that the chemical oxidation of alpha-tocopherol by benzoyl peroxide or N-bromosuccinimide in the presence of methanol should provide 9-methoxy-alpha-tocopheron. To confirm that these two compounds were diastereomers, a circular dichroism detector was used. The signs of both peaks detected by the circular dichroism detector at 230 nm were opposite. In addition to observations of identical mass and ultraviolet spectra, these results indicated that the two products were diastereomers of 9-methoxy-alpha-tocopheron, whose stereochemistry is different at the newly generated chiral center of the 9-position. The on-line use of a circular dichroism detector with an electrochemical cell/liquid chromatography system may expand the utility of the system to study the metabolism of a chiral drug. 相似文献
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