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21.
Kinetics of Lifetime Changes in Bimetallic Nanocatalysts Revealed by Quick X‐ray Absorption Spectroscopy
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Dr. Matthias Filez Dr. Hilde Poelman Dr. Evgeniy A. Redekop Dr. Vladimir V. Galvita Dr. Konstantinos Alexopoulos Dr. Maria Meledina Dr. Ranjith K. Ramachandran Dr. Jolien Dendooven Prof. Christophe Detavernier Prof. Gustaaf Van Tendeloo Dr. Olga V. Safonova Dr. Maarten Nachtegaal Prof. Bert M. Weckhuysen Prof. Guy B. Marin 《Angewandte Chemie (International ed. in English)》2018,57(38):12430-12434
22.
Stokvis E Nan-Offeringa LG Ouwehand M Tibben MM Rosing H Schnaars Y Grigat M Romeis P Schellens JH Beijnen JH 《Rapid communications in mass spectrometry : RCM》2004,18(13):1465-1471
The development of a liquid chromatography/tandem mass spectrometric assay for the quantitative analysis of the novel tubulin inhibitor D-24851 in human plasma and urine is described. D-24851 and the deuterated internal standard were extracted from 250 microL of plasma or urine using hexane/ether (1:1, v/v). Subsequently, 10-microL aliquots of reconstituted extracts were injected onto an Inertsil ODS analytical column (50 x 2.0 mm i.d., 5 microm particle size). An eluent consisting of methanol/5 mM ammonium acetate, 0.004% formic acid in water (80:20, v/v) was pumped at a flow rate of 0.2 mL/min. An API 365 triple quadrupole mass spectrometer was used in the multiple reaction monitoring mode for sensitive detection. For human plasma a dynamic range of 1-1000 ng/mL was validated, and for human urine a range of 0.25-50 ng/mL. Validation was performed according to the most recent FDA guidelines and all results were within requirements. The assay has been successfully applied to support a phase I clinical trial with orally administered D-24851. 相似文献
23.
Serial studies on the behaviour of simple and complex cyanides against the attack of dilute sulphuric acid within the determination of “total cyanide” in waste water resulted in the cyanide complexes of zinc, cadmium, copper, nickel, iron(II) and iron(III) being decomposed quite rapidly by dilute sulphuric acid in the concentration range of ≦ 100 mg CN-/l. Consequently, in such cases the total amount of cyanide can be determined in the first 25 ml of the distillate. 相似文献
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26.
Carola W. N. Damen Hilde Rosing Jan H. M. Schellens Jos H. Beijnen 《Analytical and bioanalytical chemistry》2009,394(4):1171-1182
A sensitive, specific and efficient high-performance liquid chromatography-tandem mass spectrometry assay for the simultaneous
determination of vincristine and actinomycin-D in human dried blood spots is presented. Dried blood spots were punched out
of a collection paper with a 0.25-in.-diameter punch. The analytes were extracted from the punched-out disc using sonication
during 15 min in a mixture of acetonitrile–methanol–water (1:1:1, v/v/v) containing the internal standard vinorelbine. Twenty-microlitre volumes were injected onto the HPLC system. Separation was
achieved on a 50 × 2.1 mm ID Xbridge C18 column using elution with 1 mM ammonium acetate–acetonitrile (70:30, v/v) adjusted to pH 10.5 with ammonia and run in a gradient with methanol at a flow rate of 0.4 mL/min. HPLC run time was 6 min.
The assay quantifies vincristine from 1 to 100 ng/mL and actinomycine-D from 2 to 250 ng/mL using a blood sample obtained
by a simple finger prick. Validation results demonstrate that vincristine and actinomycin-D can be accurately and precisely
quantified in human dried blood spots with the presented method. The assay can now be used to support clinical pharmacologic
studies with vincristine and actinomycin-D. 相似文献
27.
Vainchtein LD Thijssen B Stokvis E Rosing H Schellens JH Beijnen JH 《Biomedical chromatography : BMC》2006,20(1):139-148
A sensitive and specific LC-MS/MS assay for the determination of paclitaxel and its 3'p- and 6-alpha-hydroxy metabolites is presented. A 200 microL plasma aliquot was spiked with a 13C6-labeled paclitaxel internal standard and extracted with 1.0 mL tert-butylmethylether. Dried extracts were reconstituted in 0.1 M ammonium acetate-acetonitrile (1:1, v/v) and 25 microL volumes were injected onto the HPLC system. Separation was performed on a 150 x 2.1 mm C18 column using an alkaline eluent (10 mm ammonium hydroxide-methanol, 30:70, v/v). Detection was performed by positive ion electrospray followed by tandem mass spectrometry. The assay quantifies a range for paclitaxel from 0.25 to 1000 ng/mL and metabolites from 0.25 to 100 ng/mL using 200 microL human plasma samples. Validation results demonstrate that paclitaxel and metabolite concentrations can be accurately and precisely quantified in human plasma. This assay is now used to support clinical pharmacologic studies with paclitaxel. 相似文献
28.
Frankfort SV Ouwehand M van Maanen MJ Rosing H Tulner LR Beijnen JH 《Rapid communications in mass spectrometry : RCM》2006,20(22):3330-3336
A sensitive and specific high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) assay for the determination of rivastigmine and its major metabolite NAP 226-90 is presented. A 100 microL plasma aliquot was spiked with a structural analogue of rivastigmine as internal standard (PKF214-976-AE-1) and proteins were precipitated by adding 200 microL of methanol. After centrifugation a volume of 100 microL of the clear supernatant was mixed with 100 microL of methanol/water (30:70, v/v) and volumes of 25 microL were injected onto the HPLC system. Separation was acquired on a 150 x 2.0 mm i.d. Gemini C18 column using a gradient system with 10 mM ammonium hydroxide and methanol. Detection was performed by using a turboionspray interface and positive ion multiple reaction monitoring by tandem mass spectrometry. The assay quantifies rivastigmine from 0.25 to 50 ng/mL and its metabolite NAP 226-90 from 0.50 to 25 ng/mL, using human plasma samples of 100 microL. Validation results demonstrate that rivastigmine and metabolite concentrations can be accurately and precisely quantified in human EDTA plasma. This assay is now used to support clinical pharmacologic studies with rivastigmine. 相似文献
29.
A novel procedure is developed to describe and reproduce experimental coherent anti-Stokes Raman scattering (CARS) data, with particular emphasis on highly congested spectral regions. The approach, exemplified here with high-quality multiplex CARS data, makes use of spontaneous Raman scattering results. It is shown that the underlying vibrational Raman response can be retrieved from the multiplex CARS spectra, so that the Raman spectrum can be reconstituted, provided an adequate signal-to-noise ratio (SNR) is present in the experimental data and sufficient a priori knowledge of the vibrational resonances involved exists. The conversion of CARS to Raman data permits a quantitative interpretation of CARS spectra. This novel approach is demonstrated for highly congested multiplex CARS spectra of adenosine mono-, di-, and triphosphate (AMP, ADP, and ATP), nicotinamide adenine dinucleotide (NAD+), and small unilamellar vesicles (SUVs) of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). Quantitative determination of nucleotide concentrations and composition analysis in mixtures is demonstrated. 相似文献
30.
Wang W Cuyckens F Van den Heuvel H Apers S Pieters L Steenkamp V Stewart MJ Luyckx VA Claeys M 《Rapid communications in mass spectrometry : RCM》2003,17(1):49-55
Two novel compounds, 8-C-D-glucopyranosyl-7-hydroxy-5-methylchromone-2-carboxylic acid and a 2-O'-p-coumaroyl derivative thereof, were identified in a herbal tea that caused severe vomiting in a South African patient who had taken the traditional remedy to clean his stomach. For structural characterization, electrospray (ES) ionization in combination with collision-induced dissociation (CID) and tandem mass spectrometry (MS/MS) were used, as well as UV and nuclear magnetic resonance (NMR) spectroscopy. Specific ions or neutral losses generated under conditions of ES-MS/CID/MS permitted the establishment of structural features such as the free carboxyl group, the C-hexosidic part and the p-coumaroyl group. NMR spectroscopy was necessary to support the structure of the chromone-type aglycone and the glucosidic parts. Since the compounds are structurally related to aloesin and aloeresin A, which are chemotaxonomic markers of Aloe species, and have not been previously reported, we propose that they were formed by oxidative degradation during preparation of the herbal tea from an Aloe species or during its storage. 相似文献