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91.
Otake K Azukizawa S Takahashi K Fukui M Shibabayashi M Kamemoto H Kasai M Shirahase H 《Chemical & pharmaceutical bulletin》2011,59(7):876-879
2-Acyl-tetrahydroisoquinoline-3-carboxylic acid derivatives were synthesized and biologically evaluated. (S)-2-(2,4-Hexadienoyl)-7-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (14) showed peroxisome proliferator-activated receptor γ (PPARγ) and PPARα agonist activities and protein-tyrosine phosphatase 1B (PTP-1B) inhibitory activities. PPARγ agonist activity of 14 was comparable to that of rosiglitazone, and PTP-1B inhibitory activity was about 10-fold weaker than that of ertiprotafib, a PTP-1B inhibitor. Compound 14 showed high oral absorption in rats and potent hypoglycemic effects in KK-A(y) mice. In conclusion, 14 would be an excellent lead compound for a new type of anti-diabetic drug with triple actions. 相似文献
92.
Kazuto Hatakeyama Mohammad Razaul Karim Chikako Ogata Hikaru Tateishi Asami Funatsu Takaaki Taniguchi Michio Koinuma Shinya Hayami Yasumichi Matsumoto 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2014,126(27):7117-7120
Proton conductivities of layered solid electrolytes can be improved by minimizing strain along the conduction path. It is shown that the conductivities (σ) of multilayer graphene oxide (GO) films (assembled by the drop‐cast method) are larger than those of single‐layer GO (prepared by either the drop‐cast or the Langmuir‐Blodgett (LB) method). At 60 % relative humidity (RH), the σ value increases from 1×10−6 S cm−1 in single‐layer GO to 1×10−4 and 4×10−4 S cm−1 for 60 and 200 nm thick multilayer films, respectively. A sudden decrease in conductivity was observed for with ethylenediamine (EDA) modified GO (enGO), which is due to the blocking of epoxy groups. This experiment confirmed that the epoxide groups are the major contributor to the efficient proton transport. Because of a gradual improvement of the conduction path and an increase in the water content, σ values increase with the thickness of the multilayer films. The reported methods might be applicable to the optimization of the proton conductivity in other layered solid electrolytes. 相似文献
93.
Tatsuro Endo Hikaru TakizawaYasunori Imai Yasuko Yanagida Takeshi Hatsuzawa 《Applied Surface Science》2011,257(7):2560-2566
The specific optical characteristics which can be observed from noble metal nanostructured materials such as nanoparticles and nanoislands have wide variety of applications such as biosensors, solar cells, and optical circuit. Because, these noble metal nanostructures induce the increment of light absorption efficiency by the enhancing effect of electrical field from localized surface plasmon resonance (LSPR) excitation. However, the enhancing effects of electrical field from LSPR using simple structured noble metal nanostructures for several applications are not satisfactory. To realize the more effective light absorption efficiency by the enhancing effect of electrical field, quite different noble metal nanostructures have been desired for applying to several applications using LSPR. In this study, to obtain the more effective enhancing effect of electrical field, conditions for LSPR excitation using a gold-capped nanoparticle layer substrate are computationally analyzed using finite-difference time-domain (FDTD) method. From the previous research, LSPR excitation using such gold-capped nanoparticle layer substrates has a great potential for application to high-sensitive label-free monitoring of biomolecular interactions. For understanding of detailed LSPR excitation mechanism, LSPR excitation conditions were investigated by analyzing the electrical field distribution using simulation software and comparing the results obtained with experimental results. As a result of computational analysis, LSPR excitation was found to depend on the particle alignment, interparticle distance, and excitation wavelength. Furthermore, the LSPR optical characteristics obtained from the simulation analysis were consistent with experimentally approximated LSPR optical characteristics. Using this gold-capped nanoparticle layer substrate, LSPR can be excited easily more than conventional noble metal nanoparticle-based LSPR excitation without noble metal nanoparticle synthesis. Hence, this structure is detectable a small change of refractive index such as biomolecular interactions for biosensing applications. 相似文献
94.
Azusa Kondoh Masafumi Oishi Hikaru Tezuka Masahiro Terada 《Angewandte Chemie (International ed. in English)》2020,59(19):7472-7477
In the field of chiral Brønsted base catalysis, a new generation of chiral catalysts has been highly anticipated to overcome the intrinsic limitation of pronucleophiles that are applicable to the enantioselective reactions. Herein, we reveal conceptually new chiral Brønsted base catalysts consisting of two different organobase functionalities, one of which functions as an organosuperbase and the other as the substrate recognition site. Their prominent activity, which stems from the distinctive cooperative function by the two organobases in a single catalyst molecule, was demonstrated in the unprecedented enantioselective direct Mannich‐type reaction of α‐phenylthioacetate as a less acidic pronucleophile. The present achievement would provide a new guiding principle for the design and development of chiral Brønsted base catalysts and significantly broaden the utility of Brønsted base catalysis in asymmetric organic synthesis. 相似文献
95.
Yuichi Negishi Hikaru Horihata Ayano Ebina Sayuri Miyajima Mana Nakamoto Ayaka Ikeda Tokuhisa Kawawaki Sakiat Hossain 《Chemical science》2022,13(19):5546
To use atomically precise metal nanoclusters (NCs) in various application fields, it is essential to establish size-selective synthesis methods for the metal NCs. Studies on thiolate (SR)-protected gold NCs (Aun(SR)m NCs) revealed that the atomically precise Aun(SR)m NC, which has a different chemical composition from the precursor, can be synthesized size-selectively by inducing transformation in the framework structure of the metal NCs by a ligand-exchange reaction. In this study, we selected the reaction of [Au25(SC2H4Ph)18]− (SC2H4Ph = 2-phenylethanethiolate) with 4-tert-butylbenzenethiol (tBuPhSH) as a model ligand-exchange reaction and attempted to obtain new metal NCs by changing the amount of thiol, the central atom of the precursor NCs, or the reaction time from previous studies. The results demonstrated that [Au23(SPhtBu)17]0, [Au26Pd(SPhtBu)20]0 (Pd = palladium) and [Au24Pt(SC2H4Ph)7(SPhtBu)11]0 (Pt = platinum) were successfully synthesized in a high proportion. To best of our knowledge, no report exists on the selective synthesis of these three metal NCs. The results of this study show that a larger variety of metal NCs could be synthesized size-selectively than at present if the ligand-exchange reaction is conducted while changing the reaction conditions and/or the central atoms of the precursor metal NCs from previous studies.This study succeeded in obtaining three new thiolate protected metal nanoclusters by changing the ligand-exchange condition from previous studies. 相似文献
96.
Dr. Hikaru Yanai Teru Kawazoe Nobuyuki Ishii Prof. Dr. Bernhard Witulski Prof. Dr. Takashi Matsumoto 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(44):11442-11449
4-Aryl-1,3-dihydroxy-2-naphthoates having the less accessible 1,2,3,4-tetrasubstituted naphthalene scaffold and that show photoluminescence emission from solid state as well as in solutions, were selectively synthesized from brominated lactol silyl ethers through the 1,2-aryl-migrative ring rearrangement reaction. 相似文献
97.
98.
A synthesis of the 2-oxocephalosporin nucleus (12) has been achieved starting from penicillin V. Some physical and chemical properties of this new ring system and the preparation of the corresponding free acid 2 (R1 = CH2OC6H5) for biological testing are also described. 相似文献
99.
100.
Dr. Shinobu Arikawa Dr. Akihiro Shimizu Dr. Daisuke Shiomi Prof. Dr. Kazunobu Sato Prof. Dr. Takeji Takui Dr. Hikaru Sotome Prof. Dr. Hiroshi Miyasaka Dr. Masahito Murai Prof. Dr. Shigehiro Yamaguchi Prof. Dr. Ryo Shintani 《Angewandte Chemie (International ed. in English)》2023,62(29):e202302714
A kinetically-stabilized nitrogen-doped triangulene cation derivative has been synthesized and isolated as the stable diradical with a triplet ground state that exhibits near-infrared emission. As was the case for a triangulene derivative we previously synthesized, the triplet ground state with a large singlet-triplet energy gap was experimentally confirmed by magnetic measurements. In contrast to the triangulene derivative, the nitrogen-doped triangulene cation derivative is highly stable even in solution under air and exhibits near-infrared absorption and emission because the alternancy symmetry of triangulene is broken by the nitrogen cation. Breaking the alternancy symmetry of triplet alternant hydrocarbon diradicals by a nitrogen cation would therefore be an effective strategy to create stable diradicals possessing magnetic properties similar to the parent hydrocarbons but with different electrochemical and photophysical properties. 相似文献