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91.
The base-induced solvolysis of dibenzyl triselenocarbonate in DMSO/water (4:1) has been studied by UV spectrophotometric measurements under pseudo-first order conditions, using KOH, Me4NOH, Bu4nNOH and Bu4nNHCO3 as bases. The reaction is first order with respect to the substrate as well as to the base. Rate constants and activation parameters for the four bases indicate that the rate determining step is the nucleophilic attack by the base, as an ionic couple, on the substrate. Fast reactions, due to strong nucleophilic selenolate species, may follow this slow step; a tentative mechanism is proposed on the basis of experimental evidence. 相似文献
92.
A structure space is a quadrupleX=(X, d, A, P), where for some setR, X A=2
R
,d:X×X A is defined byd(I, J)=J–I, andP is the family of cofinite subsets ofR. Forr P, I X, N
r
(I)={J X: d(I, J) r},To(X)={Q X: if x Q there is anr P such thatN
r
(x)
Q}. ThenTo(X) is a (not usually Hausdorff) topology onX called the hull-kernel topology. Replacing d byd
*, whered
*
(I, J)=d(J, I), or byd
s, whered
s
(I, J.)=d(I, J) d
*
(I, J), and proceeding in the obvious way yields thedual hull-kernel topology
To(X
*) andsymmetric topology To(X
s
). The latter is always a zero-dimensional Hausdorff space. When R is a commutative ring with identity andX is a collection of proper prime ideals ofR, To(X
s
) is usually called thepatch topology. Our generality enables us to improve on known results in the case of space of prime ideals and to apply this theory to a wide variety of algebraic structures. In particular, we establish criteria for a subspace of a structure space to be closed in the symmetric topology; we establish a duality between families of maximal elements in the hull-kernel topology and families of minimal elements in the dual hull-kernel topology of subspaces that are closed in the symmetric topology; we use topological constructions to generalize certain ring theoretic notions, such as radical ideals an annihilator ideals; we use this theory to obtain new results about subspaces of the space prime ideals of a reduced, commutative ring.Presented by F. E. J. Linton.This author's research was supported by a grant from the CUNY-PSC research award program. 相似文献
93.
The 3-formyl-2(1)-pyridone, -thione and -selone systems have been investigated by UV photoelectron, UV-visible, 1H and 13C NMR spectroscopy. It is demonstrated that the electronic build-up of these systems as derived from the spectroscopic data may be correlated with their chemical behaviour through application of the perturbation model for chemical reactivity. 相似文献
94.
Given a complex number λ of modulus 1, we show that the bifurcation locus of the one parameter family {f
b
(z)=λz+b
z
2+z
3}
b
∈
ℂ contains quasi-conformal copies of the quadratic Julia set J(λz+z
2). As a corollary, we show that when the Julia set J(λz+z
2) is not locally connected (for example when z↦λz+z
2 has a Cremer point at 0), the bifurcation locus is not locally connected. To our knowledge, this is the first example of
complex analytic parameter space of dimension 1, with connected but non-locally connected bifurcation locus. We also show
that the set of complex numbers λ of modulus 1, for which at least one of the parameter rays has a non-trivial accumulation
set, contains a dense G
δ subset of S
1.
Received: 22 September 2000 / Accepted: 16 January 2001 相似文献
95.
Tissue characterization for separating malignant from benign tissue is a clinically very important potential of magnetic resonance imaging (MRI). In this study quantitative determination of T1- and T2-relaxation processes was accomplished in five healthy volunteers, 10 patients with benign hyperplasia of the prostate gland and eight patients with prostatic carcinoma. Histological verification was obtained in all the patients. The measurements were performed on a wholebody MR-scanner operating at 1.5 T using six inversion recovery sequences (TR = 4000 msec) for T1-determination and a 32 spin-echo sequence (TR = 3000 or 2000 msec) for T2-estimation. The T1-relaxation curves all appeared monoexponential, whereas the T2-curves in most cases showed a multiexponential behaviour. A considerable overlap of the relaxation curves was seen. Consequently, we found no statistically significant differences between the T1- or the T2-relaxation times of the three groups investigated. It is concluded that tissue characterization based on relaxation time measurements with MRI does not seem to have a clinically useful role in prostatic disease. 相似文献
96.
In vivo magnetic resonance diffusion measurement in the brain of patients with multiple sclerosis. 总被引:4,自引:0,他引:4
H B Larsson C Thomsen J Frederiksen M Stubgaard O Henriksen 《Magnetic resonance imaging》1992,10(1):7-12
Measurement of water self-diffusion in the brain in 25 patients with multiple sclerosis was performed by magnetic resonance imaging. Quantitative diffusion measurements were obtained using single spin-echo pulse sequences with pulsed magnetic field gradients of different magnitude. Twenty-two of these patients also underwent measurement of the transverse relaxation time (T2). Only one plaque was evaluated in each patient. Based on prior knowledge, 12 plaques were classified as being 3 mo or less in age, and 7 plaques were classified as being more than 3 mo old. In all 25 plaques, water self-diffusion was found to be higher than in apparently normal white matter. Furthermore, water self-diffusion was found to be higher in acute plaques compared with chronic plaques. Finally, a slight tendency toward a relationship between the diffusion capability and T2 was found. We believe that an increased diffusion capability signifies an increase of the extracellular water space, which probably is related to the degree of demyelination. Thus, measurement of water self-diffusion in multiple sclerosis plaques may contribute to the study of pathogenesis of demyelination. 相似文献
97.
Jian Yin Niel M. Henriksen David R. Slochower Michael K. Gilson 《Journal of computer-aided molecular design》2017,31(1):133-145
The absolute binding free energies and binding enthalpies of twelve host–guest systems in the SAMPL5 blind challenge were computed using our attach-pull-release (APR) approach. This method has previously shown good correlations between experimental and calculated binding data in retrospective studies of cucurbit[7]uril (CB7) and β-cyclodextrin (βCD) systems. In the present work, the computed binding free energies for host octa acid (OA or OAH) and tetra-endo-methyl octa-acid (TEMOA or OAMe) with guests are in good agreement with prospective experimental data, with a coefficient of determination (R2) of 0.8 and root-mean-squared error of 1.7 kcal/mol using the TIP3P water model. The binding enthalpy calculations achieve moderate correlations, with R2 of 0.5 and RMSE of 2.5 kcal/mol, for TIP3P water. Calculations using the newly developed OPC water model also show good performance. Furthermore, the present calculations semi-quantitatively capture the experimental trend of enthalpy-entropy compensation observed, and successfully predict guests with the strongest and weakest binding affinity. The most populated binding poses of all twelve systems, based on clustering analysis of 750 ns molecular dynamics (MD) trajectories, were extracted and analyzed. Computational methods using MD simulations and explicit solvent models in a rigorous statistical thermodynamic framework, like APR, can generate reasonable predictions of binding thermodynamics. Especially with continuing improvement in simulation force fields, such methods hold the promise of making substantial contributions to hit identification and lead optimization in the drug discovery process. 相似文献
98.
Over the past 10 years a number of new techniques have emerged that allow the manipulation of single DNA molecules and other biopolymers (RNA, proteins, etc.). These experiments have permitted the measurement of the DNA stretching and twisting elasticity and have consequently revealed the essential role played by the DNA mechanical properties in its interactions with proteins. We shall first describe the different methods used to stretch and twist single DNA molecules. We will then focus on its behaviour under torsion, especially by discussing the different methods used to estimate its torsional modulus. 相似文献
99.
Starting from 2,4-dichloroquinazoline, various methods for the selective removal of the 4-chloro substituent were tested, including catalytic hydrogenation, metal-halogen exchange, metal hydride reduction and reduction with tributyltin hydride—the latter both in a radical and in a Stille-type reaction. Amongst these, the most efficient method was found to be the Stille-type coupling. Furthermore, we have studied the reactivity of 2-chloroquinazoline and found it to act as a versatile building block for the direct introduction of the 2-quinazolinyl moiety. 相似文献
100.
Velardez GF Lemke HT Breiby DW Nielsen MM Møller KB Henriksen NE 《The journal of physical chemistry. A》2008,112(35):8179-8187
The structures of the ground and excimer states of perylene pairs are calculated [using density functional theory (DFT) and time-dependent DFT techniques] in a free as well as a crystal environment, and their spectroscopic properties are studied for the most stable configurations. The vertical transition energies for the absorption and emission bands are obtained, and they are in good agreement with experimental data. In these calculations, up to six excited states are considered. With the calculated structures of the ground and excimer states, the scattering factors are analyzed as a function of the concentration of excimers in a crystal. The intensity of the 110, 005, and 0 10 0 reflections are found to be fairly sensitive to the presence of excimers in the crystal. The finite (nanosecond) lifetime of the excimer may make it possible to observe this state using time-resolved X-ray diffraction techniques. 相似文献