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61.
Janssen SA Vos H van Kempen EE Breugelmans OR Miedema HM 《The Journal of the Acoustical Society of America》2011,129(4):1953-1962
Recently, it has been suggested that the annoyance of residents at a given aircraft noise exposure level increases over the years. The objective of the present study was to verify the hypothesized trend and to identify its possible causes. To this end, the large database used to establish earlier exposure-response relationships on aircraft noise was updated with original data from several recent surveys, yielding a database with data from 34 separate airports. Multilevel grouped regression was used to determine the annoyance response per airport, after which meta-regression was used to investigate whether study characteristics could explain the heterogeneity in annoyance response between airports. A significant increase over the years was observed in annoyance at a given level of aircraft noise exposure. Furthermore, the type of annoyance scale, the type of contact, and the response percentage were found to be sources of heterogeneity. Of these, only the scale factor could statistically account for the trend, although other findings rule it out as a satisfactory explanation. No evidence was found for increased self-reported noise sensitivity. The results are of importance to the applicability of current exposure-annoyance relationships for aircraft noise and provide a basis for decisions on whether these need to be updated. 相似文献
62.
Margriet V. D. Z. Park Iseult Lynch Sonia Ram��rez-Garc��a Kenneth A. Dawson Liset de la Fonteyne Eric Gremmer Wout Slob Jacob J. Bried�� Andreas Elsaesser C. Vyvyan Howard Henk van Loveren Wim H. de Jong 《Journal of nanoparticle research》2011,13(12):6775-6787
The biological response to four well-characterized amorphous silica nanoparticles was investigated in RAW 264.7 macrophages in view of their potential application as drug carriers to sites of inflammation. All silica nanoparticles-induced cell membrane damage, reduced metabolic activity, generated ROS and released various cytokines, but to different extents. Two silica nanoparticles of 34 nm (A and B) with different zetapotentials were more cytotoxic than (aggregated) 11 and 248 nm nanoparticles, while cytokines were mostly induced by the (aggregated) 11 nm and only one of the 34 nm nanoparticles (34A). The results indicate that specific silica nanoparticles may have counterproductive effects, for example when used as carriers of anti-inflammatory drugs. The physicochemical properties determining the response of nanoparticles vary for different responses, implying that a screening approach for the safe development of nanoparticles needs to consider the role of combinations of (dynamic) physicochemical properties and needs to include multiple toxicity endpoints. 相似文献
63.
A queueing analysis is presented for base-stock controlled multi-stage production-inventory systems with capacity constraints. The exact queueing model is approximated by replacing some state-dependent conditional probabilities (that are used to express the transition rates) by constants. Two recursive algorithms (each with several variants) are developed for analysis of the steady-state performance. It is analytically shown that one of these algorithms is equivalent to the existing approximations given in the literature. The system studied here is more general than the systems studied in the literature. The numerical investigation for three-stage systems shows that the proposed approximations work well to estimate the relevant performance measures. 相似文献
64.
A generalized Nevanlinna function Q(z) with one negative square has precisely one generalized zero of nonpositive type in the closed extended upper halfplane. The fractional linear transformation defined by Qτ(z)=(Q(z)−τ)/(1+τQ(z)), τ∈R∪{∞}, is a generalized Nevanlinna function with one negative square. Its generalized zero of nonpositive type α(τ) as a function of τ is being studied. In particular, it is shown that it is continuous and its behavior in the points where the function extends through the real line is investigated. 相似文献
65.
Henk M. Buck 《International journal of quantum chemistry》2011,111(15):4472-4482
We describe with molecular model studies based on the intrinsic parameters of van't Hoff's regular tetrahedron nucleophilic and electrophilic addition‐substitution reactions via a selected reaction coordinate for the displacement of carbon. Geometries of stable, intermediate transition complexes or transition states are compared with the corresponding ab initio values. Specific attention is given on the hypervalent and nonhypervalent character of carbon supported by ab initio calculations, our model consideration and experimental evidence. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2011 相似文献
66.
Jaap Noordmans Herbert Wormeester Henk J. Busscher 《Colloids and surfaces. B, Biointerfaces》1999,15(3-4):227-233
In this paper two in situ techniques are combined to simultaneously examine protein adsorption at the solid–liquid interface from sessile solution droplets. With axisymmetric drop shape analysis by profile (ADSA-P) the change in solid–liquid interfacial tension is determined, while ellipsometry is employed to measure the amount of protein adsorbed from the same solution droplet at the solid–liquid interface. Three proteins (human serum albumin (HSA), immunoglobulin G (IgG) and fibrinogen (Fb)) were dissolved to a concentration of 0.05 mg ml−1 in PBS (pH 7) and sessile droplets were placed for 2 h on a 47.8 nm thick gold coating on glass. The gold coated glass was positioned onto a quartz prism with immersion oil. The prism was aligned in a rotating analyser ellipsometer and the optical beam was thus allowed to be reflected at the hydrophobic gold surface. The ADSA-P set-up was built in 90° cross-beamed set-up around the prism. By combining the results for the adsorbed amounts and the interfacial tension changes over the two hour adsorption period, two stages in the adsorption process could be distinguished. In the first stage, the adsorbed amounts increase in correspondence with the interfacial tension changes, indicating that the interfacial tension changes are caused by adsorption, whereas in the second stage interfacial tension changes continue despite the adsorbed amounts being constant. Consequently, the second stage must be associated with conformational changes of the adsorbed proteins. For HSA and Fb, the conformational contribution to the interfacial tension changes (7.8 and 5.3 mJ m−2, respectively) were approximately 2-fold the adsorption contribution, while for IgG both were equal around 3 mJ m−2. 相似文献
67.
Martin Giera Jon S. B. de Vlieger Henk Lingeman Hubertus Irth Wilfried M. A. Niessen 《Rapid communications in mass spectrometry : RCM》2010,24(10):1439-1446
Structural elucidation of six regioisomers of mono‐N‐octyl derivatized neomycin is achieved using MSn (up to n = 4) on an ion trap time‐of‐flight (IT‐TOF) instrument equipped with electrospray ionization. The mixture of six derivatized neomycin analogues was generated by reductive amination in a shotgun synthetic approach. In parallel to the liquid chromatography/mass spectrometry (LC/MS) detection, the antibacterial activity of the neomycin regioisomers was tested by post‐column addition of buffer and bacterial inocula, subsequent microfractionation of the resulting mixture, incubation, and finally a chemiluminescence‐based bioactivity measurement based on the production of bacterial ATP. The MS‐based high‐resolution screening approach described can be applied in medicinal chemistry to help in designing and producing new antibiotic substances, which is particularly challenging due to the high functionality of most antibiotic substances, therefore requiring advanced (hyphenated) separation and detection techniques for compound mixtures. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
68.
69.
Quality management of laboratory medicine has become a hot topic at many conferences. Also, many national and international
organizations have created working groups and committees with the task of working out standards, guidelines or recommendations
for quality management of medical laboratories. We have observed that there is a great deal of interest not only from professional
and scientific organizations directly involved in medical laboratory tests, but also from accreditation and certification
bodies, from test laboratories in general, from in vitro diagnostic devices (IVD) manufacturers and their associations, and
from other medical laboratory suppliers. However, we found that all these parties were discussing from their own point of
view, without taking into account the position of other involved partners and that there was a need for creating a discussion
forum for quality management in clinical laboratories. So in 1995, we started the Antwerp conferences on quality (r)evolution
in clinical laboratories. The aim was to bring together all concerned partners and to establish a forum for brainstorming,
independently of any pressure group. The leitmotif for the Antwerp conferences (Fig. 1) is a chain model showing the interfaces
and relationships between all the partners involved in laboratory tests. During the conferences, this chain model has been
examined from different angles and a summary of the concepts evolving from the discussions can be found in the conference
abstracts and conference review reports in this journal. A Selection of ideas emerging from these conferences are presented
below.
Received: 5 October 1998 · Accepted: 20 October 1998 相似文献
70.
MartinHenk GeorgeA.Tsintsifas 《数学进展》2007,36(4):441-446
对于一个给定椭球,本文给出了它的任一全等椭球都包含一个整点的一个充分必要条件. 相似文献