Base-induced cycloaddition of N-(tosylmethyl)imino compounds to michael acceptors. Synthesis of 2,3,4-trisubstituted pyrroles

A series of N-(tosylmethyl)imino compounds [TosCH₂N?C(L)A] has been prepared, and applied to a new, base-induced, one-operational synthesis of otherwise more difficultly accessible 2,3,4-trisubstituted pyrroles from electron deficient olefins. This regiospecific process probably is an 1,3-anionic cycloaddition, combined with the elimination of sulfinic acid and a leaving group L. The group A is retained as the 2-substituent of the resulting pyrroles.     

Can the renormalization of the interaction describe the effects of (A+2)particles-2 holes excitations?

Using the statistical model, an estimate is obtained for the critical angular momentum when the rotational band ofγ-rays ends up in reactions with heavy ions. A model of classical non-quantized rotation is proposed for angular momenta exceeding the critical value. Estimates for the intensity ofγ-radiation and the descend time along the yrast-line proceeding the quantal rotation are given.     

On kaonic hydrogen. Phenomenological quantum field theoretic model revisited

We argue that due to isospin and U-spin invariance of strong low-energy interactions the S-wave scattering lengths a ⁰ ₀ and a ¹ ₀ of ˉN scattering with isospin I = 0 and I = 1 satisfy the low-energy theorem a ⁰ ₀ +3a ¹ ₀ = 0 valid to leading order in chiral expansion. In the model of strong low-energy ˉN interactions at threshold (Eur. Phys. J. A 21, 11 (2004)) we revisit the contribution of the Σ(1750) resonance, which does not saturate the low-energy theorem a ⁰ ₀ +3a ¹ ₀ = 0, and replace it by the baryon background with properties of an SU(3) octet. We calculate the S-wave scattering amplitudes of K^-N and K^-d scattering at threshold. We calculate the energy level displacements of the ground states of kaonic hydrogen and deuterium. The result obtained for kaonic hydrogen agrees well with recent experimental data by the DEAR Collaboration. We analyse the cross-sections for elastic and inelastic K^-p scattering for laboratory momenta 70MeV/c < p _K < 150MeV/c of the incident K^--meson. The theoretical results agree with the available experimental data within two standard deviations.     

Energy level displacement of the excited $n\ell$ state of pionic hydrogen

The energy level displacements of the excited states of pionic hydrogen and the contribution of the transitions and the transitions of the pair, coupled by the attractive Coulomb field in the S-wave state with a continuous energy spectrum, to the shift of the energy level of the ground state of pionic hydrogen, caused by strong low-energy interactions, are calculated within a quantum field theoretic, relativistic covariant and model-independent approach.Received: 19 November 2003, Revised: 25 November 2003, Published online: 5 February 2004PACS: 13.75.Gx Pion-baryon interactions - 11.10.St Bound and unstable states; Bethe-Salpeter equations - 21.30.Fe Forces in hadronic systems and effective interactions - 31.15.Ar Ab initio calculationsPermanent address A.N. Ivanov: State Polytechnical University, Department of Nuclear Physics, 195251 St. Petersburg, Russian Federation;Permanent address N.I. Troitskaya: State Polytechnical University, Department of Nuclear Physics, 195251 St. Petersburg, Russian Federation.     

Analysis of the phase transitions in alkyl-mica by density and pressure profiles

In a previous work [Heinz, Castelijns, and Suter, J. Am. Chem. Soc. 115, 9500 (2003)], we developed an accurate force field and simulated the phase transitions in C18-mica (octadecyltrimethylammonium-mica) as well as the absence of such transitions in 2C18-mica (dioctadecyldimethylammonium-mica) between room temperature and 100 degrees C. Here we analyze (i) average z coordinates of the carbon atoms and interdigitation of the hydrocarbon bilayers, (ii) density profiles, and (iii) pressure profiles of the structures along all Cartesian axes. In C18-mica, the standard deviation in the z coordinate for the chain atoms is high and more than doubles in the disordered phase. The order-disorder transition is accompanied by a change in the orientation of the ammonium head group, as well as decreasing tensile and shear stress in the disordered phase. In 2C18-mica, the standard deviation in the z coordinate for the chain atoms is low and does not increase remarkably on heating. The backbones display a highly regular structure, which is slightly obscured by rotations in the C18 backbones and minor head group displacements at 100 degrees C. Close contacts between the bulky head groups with sidearms cause significant local pressure which is in part not relieved at 100 degrees C. An increase of the basal-plane spacing at higher temperature is found in both systems due to larger separation between the two hydrocarbon layers and an increased z spacing between adjacent chain atoms (=decreased tilt of the chains relative to the surface normal), and, in C18-mica only, a stronger upward orientation of the C18 chain at the ammonium head group. The likelihood for chain interdigitation between the two hydrocarbon layers is 24%-30% for C18-mica, and 65%-26% for 2C18-mica (for 20-100 degrees C).     

BSE control: detection of gelatine-derived peptides in animal feed by mass spectrometry

The epidemic of bovine spongiform encephalopathy (BSE) is thought to have resulted from feeding scrapie-infected sheep to cattle. This has led to a ban of feeding animals with "processed animal protein"(PAP). We report a novel approach for the mass spectrometric detection of PAP contamination in animal feedstuffs by detecting gelatine, a derivative of the major animal protein collagen. A method was developed to hydrolyse gelatine standards with hydrochloric acid, followed by detection of the derived hydrolytic peptides at m/z 828, 915, 957 and 1044 by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) and liquid chromatography electrospray ionisation mass spectrometry (LC-ESI-MS-MS). The marker peptides can be detected at concentrations of 100 ng ml(-1) gelatine in water with MALDI. The procedure was adapted to obtain a suitable peptide map of gelatine extracted from spiked feed. The ratio of signal area of the gelatine-derived peptide at m/z 1044 to the internal standard at m/z 556 is shown to relate to the total amount of gelatine present in the sample.