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61.
62.
Structurally Defined αMHC‐II Nanobody–Drug Conjugates: A Therapeutic and Imaging System for B‐Cell Lymphoma 下载免费PDF全文
Dr. Tao Fang Dr. Joao N. Duarte Jingjing Ling Zeyang Li Jonathan S. Guzman Prof. Dr. Hidde L. Ploegh 《Angewandte Chemie (International ed. in English)》2016,55(7):2416-2420
Antibody–drug conjugates (ADCs) of defined structure hold great promise for cancer therapies, but further advances are constrained by the complex structures of full‐sized antibodies. Camelid‐derived single‐domain antibody fragments (VHHs or nanobodies) offer a possible solution to this challenge by providing expedited target screening and validation through switching between imaging and therapeutic activities. We used a nanobody (VHH7) specific for murine MHC‐II and rendered “sortase‐ready” for the introduction of oligoglycine‐modified cytotoxic payloads or NIR fluorophores. The VHH7 conjugates outcompeted commercial monoclonal antibodies (mAbs) for internalization and exhibited high specificity and cytotoxicity against A20 murine B‐cell lymphoma. Non‐invasive NIR imaging with a VHH7–fluorophore conjugate showed rapid tumor targeting on both localized and metastatic lymphoma models. Subsequent treatment with the nanobody–drug conjugate efficiently controlled tumor growth and metastasis without obvious systemic toxicity. 相似文献
63.
Andreia F. Sousa Alessandro Gandini Armando J. D. Silvestre Carlos Pascoal Neto José J. C. Cruz Pinto Christer Eckerman Bjarne Holmbom 《Journal of polymer science. Part A, Polymer chemistry》2011,49(10):2281-2291
This article reports the successful synthesis and characterization of two types of completely biobased polymers prepared by the polycondensation or polytransesterification of suberin fragments, isolated by different procedures and from two different vegetable sources. These polymerizations were conducted with different experimental conditions in terms of the type of catalyst, the reaction medium and temperature, as well as the molar ratio between the reactive moieties. The ensuing linear or partly crosslinked polyesters were characterized by conventional spectroscopic techniques, SEC, DSC, XRD, DMA, and TGA. These hydrophobic materials represent an original contribution to the growing field of polymers from renewable resources. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011 相似文献
64.
In this work we investigate the dynamical Casimir effect in a nonideal cavity by deriving an effective Hamiltonian. We first compute a general expression for the average number of particle creation, applicable for any law of motion of the cavity boundary, under the only restriction of small velocities. We also compute a general expression for the linear entropy of an arbitrary state prepared in a selected mode, also applicable for any law of motion of a slow moving boundary. As an application of our results we have analyzed both the average number of particle creation and linear entropy within a particular oscillatory motion of the cavity boundary. On the basis of these expressions we develop a comprehensive analysis of the resonances in the number of particle creation in the nonideal dynamical Casimir effect. We also demonstrate the occurrence of resonances in the loss of purity of the initial state and estimate the decoherence times associated with these resonances. Since our results were obtained in the framework of the perturbation theory, they are restricted, under resonant conditions, to a short-time approximation. 相似文献
65.
J. A. M. S. Duarte 《Zeitschrift für Physik B Condensed Matter》1990,80(2):299-304
A method for conversion of directed site animals to their bond counterparts is used to significantly extend the number of such configurations in 2, 3, 4 dimensions, obtain their loop partition and study the singularity structure (for both dominant and subdominant singularities) of the corresponding dilute polymer transitions. A special property of bond directed configurations (equivalence lence of loop and bond perimeter partition) is exploited to obtain longer susceptibility series in 3 and 4 dimensions and the gap exponent estimate is refined into the intervals TANOPartly funded by SBF 341 (Aachen-Julich-Koln) and Reitoria Uni. Porto (Project 1-87) 相似文献
66.
67.
Ftima C. Teixeira Carla Lucas M. Joo M. Curto Antnio P. S. Teixeira M. Teresa Duarte Vnia Andr 《Heteroatom Chemistry》2016,27(1):3-11
Novel tetraethyl ethylene‐1,1‐bisphosphonate esters derived from 1H‐indazole, 1H‐pyrazolo[3,4‐b]pyridine, and 1H‐pyrazolo[3,4‐b]quinoline were synthesized by a Michael addition reaction of tetraethyl ethylidene‐1,1‐bisphosphonate with the corresponding heterocycle, using conventional heating and microwave‐assisted methods. The microwave‐assisted method provides shorter reaction times and better yields. The hydrolysis of bisphosphonates afforded the corresponding bisphosphonic acids or salt, using concentrated hydrochloric acid or TMSBr/collidine, respectively. All new compounds were fully characterized, and their structures were assigned using 1H, 31P, and 13C NMR and IR spectroscopies and mass spectrometry. The molecular structure of compound 6 was confirmed by X‐ray diffraction studies. 相似文献
68.
Batalioto F Martins OG Duarte AR Figueiredo Neto AM 《The European physical journal. E, Soft matter》2011,34(1):10
In this work we investigate the influence of the adsorption of ions on the impedance spectroscopy of an electrolytic cell.
We consider that the positive and negative ions present in a dielectric liquid are adsorbed in the electrode surfaces with
different adsorption energies. This difference in adsorption energies causes an additional plateaux in the limit of the low-frequency
range of the real part of the impedance Z . In the same frequency range, a second minimum in the imaginary part of Z is predicted. The theory is illustrated with measurements of the impedance of an electrolytic solution in the frequency range
from 10-2Hz to 1KHz. A comparison between the present model and others from the literature to describe the experimental results is
also made. 相似文献
69.
Eduardo de Almeida Paulo Rogério Massoni Amauri Antonio Menegário Laudi Cunha Leite Dante Pazzanese Duarte Lanna Virgílio Franco do Nascimento Filho 《X射线光谱测定》2011,40(6):424-426
This article describes a comparison of conventional energy‐dispersive X‐ray fluorescence (EDXRF) and synchrotron radiation total‐reflection X‐ray fluorescence (SRTXRF) for Co determination in ruminal fluid from Holstein cow. This element is used as marker for animal nutrition studies. For EDXRF, 200 µl of the sample were dried on 6.35 µm Mylar film at 60 °C. The excitation was carried out using an X‐ray tube with Mo target and Zr filter operated at 30 kV/20 mA. For SRTXRF, 10 µl of the sample were pipetted on a Lucite carrier and dried at 60 °C. In both the techniques, Ga was used as internal standard and the acquisition time was 200 s. The trueness of both techniques was evaluated through the standard addition method, the recoveries obtained by SRTXRF and EDXRF were 76 and 99%, and the limits of detection, 13 and 240 µg l?1, respectively. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
70.
Vicente Campos Rafael Martí Jesús Sánchez-Oro Abraham Duarte 《The Journal of the Operational Research Society》2014,65(12):1800-1813
In this paper, we address an optimization problem resulting from the combination of the well-known travelling salesman and knapsack problems. In particular, we target the orienteering problem, originated in the context of sport, which consists of maximizing the total score associated with the vertices visited in a path within the available time. The problem, also known as the selective travelling salesman problem, is NP-hard and can be formulated as an integer linear program. Since the 1980s, several solution methods for this problem have been developed and applied to a variety of fields, particularly in routing and tourism. We propose a heuristic method—based on the Greedy Randomized Adaptive Search Procedure (GRASP) and the Path Relinking methodologies—for finding approximate solutions to this optimization problem. We explore different constructive methods and combine two neighbourhoods in the local search of GRASP. Our experimentation with 196 previously reported instances shows that the proposed procedure obtains high-quality solutions employing short computing times. 相似文献