Variable coordination mode of chloranilic acid. Synthesis, structure, and electrochemical properties of some osmium complexes

Reaction of chloranilic acid (H2ca) with [Os(bpy)2 Br2] (bpy = 2,2'-bipyridine) affords a dinuclear complex of type [{Os(bpy)2}2 (ca)]2+, isolated as the perchlorate salt. A similar reaction of H2ca with [Os(PPh3)2 (pap)Br2] (pap = 2-(phenylazo)pyridine) affords a dinuclear complex of type [{Os(PPh3)2 (pap)}2 (ca)]2+ (isolated as the perchlorate salt) and a mononuclear complex of type [Os(PPh3)2 (pap)(ca)]. Reaction of H2ca with [Os(PPh3)2(CO)2(HCOO)2] gives a dinuclear complex of type [{Os(PPh3)2(CO)2}2 (r-ca)], where r-ca is the two electron reduced form of the chloranilate ligand. The structures of the [{Os(PPh3)2 (pap)}2 (ca)](ClO4)2, [Os(PPh3)2 (pap)(ca)], and [{Os(PPh3)2(CO)2}2 (r-ca)] complexes have been determined by X-ray crystallography. In the [{Os(bpy)2}2 (ca)]2+ and [{Os(PPh3)2 (pap)}2 (ca)]2+ complexes, the chloranilate dianion is serving as a tetradentate bridging ligand. In the [Os(PPh3)2 (pap)(ca)] complex, the chloranilate dianion is serving as a bidentate chelating ligand. In the [{Os(PPh3)2(CO)2}2 (r-ca)] complex, the reduced form of the chloranilate ligand (r-ca(4-)) is serving as a tetradentate bridging ligand. All the four complexes are diamagnetic and show intense metal-to-ligand charge-transfer transitions in the visible region. The [Os(PPh3)2 (pap)(ca)] complex shows an Os(II)-Os(III) oxidation, followed by an Os(III)-Os(IV) oxidation on the positive side of a standard calomel electrode. The three dinuclear complexes show two successive oxidations on the positive side of SCE. The mixed-valent Os(II)-Os(III) species have been generated in the case of the two chloranilate-bridged complexes by coulometric oxidation of the homovalent Os(II)-Os(II) species. The mixed-valent Os(II)-Os(III) species show intense intervalence charge-transfer transitions in the near-IR region.     

Antibodies as Tailor-Made Chiral Selectors: an Interdisciplinary Approach to Enantiomer Separation and Detection

 It has long been known that the configurational isomers of biologically active compounds, e.g., nutrients, pesticides, and drugs, may exhibit different activities in a chiral environment such as the human body. Although the majority of drugs presently in development are chiral, analytical and preparative methods for the quantitative determination and purification of stereoisomers still lag behind. One reason is that commonly used chiral selectors for the direct resolution of enantiomers are not tailor-made for a specific analyte. The identification of suitable selectors for a particular pair of enantiomers still requires considerable experimentation and is generally demanding with regard to material, time and labor. The rational design of chiral host molecules, therefore, represents a challenge in facilitating enantiomer analysis. In this article, we describe how a combination of techniques ranging from organic synthesis to molecular biology yields antibodies of predetermined specificity and stereoselectivity that can be used as tailor-made chiral selectors for the chromatographic separation of enantiomers and their sensitive detection in immunosensors.     

Chiral separation of halogenated amino acids by ligand-exchange capillary electrophoresis

The chiral separation of halogenated amino acids by ligand-exchange CE is described. Halogenated amino acids attracted increasing interest in recent years because of their physiological activities. Different chiral selectors, as there are L-4-hydroxyproline, L-histidine, and N-alkyl derivatives of L-4-hydroxyproline in form of their copper(II) complexes, are compared for their chiral recognition ability for halogenated amino acids. The influence of various parameters, such as selector concentration, pH, organic modifier, and field strength, on the resolution was investigated. All halogenated amino acids investigated were baseline-separated under optimized conditions.     

Extending the GGobi pipeline from R

This paper describes progress towards developing a platform for rapid prototyping of interactive data visualizations, using R, GGobi, rggobi and RGtk2. GGobi is a software tool for multivariate interactive graphics. At the core of GGobi is a data pipeline that incrementally transforms data through a series of stages into a plot and maps user interaction with the plot back to the data. The GGobi pipeline is extensible and mutable at runtime. The rggobi package, an interface from the R language to GGobi, has been augmented with a low-level interface that supports the customization of interactive data visualizations through the extension and manipulation of the GGobi pipeline. The large size of the GGobi API has motivated the use of the RGtk2 code generation system to create the low-level interface between R and GGobi. The software is demonstrated through an application to interactive network visualization.     

Rapid Automatic Determination of Calcium and Magnesium in Aqueous Solutions by FIA Using Potentiometric Detection

A pH‐sensitive detector for flow‐through potentiometry based on a graphite/quinhydrone/silicone composite electrode was applied to determine calcium and magnesium in aqueous solutions. The determinations are performed by FIA titrations with EDTA as the carrier solution. The method was applied to the analysis of mineral water, drinking water, and river water. The results were compared with those obtained by batch complexometric titration. The proposed new method is suitable for the simple, rapid and automated determination of water hardness in small sample volumes of aqueous solutions. The detection limit for both ions is about 1×10^?5 mol L^?1, the standard deviation is less than 2%. The sampling frequency is 60 determinations per hour.     

Novel multicolor fluorescently labeled silica nanoparticles for interface fluorescence resonance energy transfer to and from labeled avidin

Fluorescent silica nanoparticles (SiNPs) were prepared by covalent attachment of fluorophores to the amino-modified surface of SiNPs with a typical diameter of 15 nm. The SiNPs are intended for use in novel kinds of fluorescence resonance energy transfer (FRET)-based affinity assays at the interface between nanoparticle and sample solution. Various labels were employed to obtain a complete set of colored SiNPs, with excitation maxima ranging from 337 to 659 nm and emission maxima ranging from 436 nm to the near infrared (710 nm). The nanoparticles were characterized in terms of size and composition using transmission electron microscopy, thermogravimetry, elemental analysis, and dynamic light scattering. The surface of the fluorescent SiNPs was biotinylated, and binding of labeled avidin to the surface was studied via FRET in two model cases. In the first, FRET occurs from the biotinylated fluorescent SiNP (the donor) to the labeled avidin (the acceptor). In the second, FRET occurs in the other direction. Aside from its use in the biotin–avidin system, such SiNPs also are believed to be generally useful fluorescent markers in various kinds of FRET assays, not the least because the fluorophore is located on the surface of the SiNPs (and thus always much closer to the second fluorophore) rather than being doped deep in its interior.     

Graphene as a reversible spin manipulator of molecular magnets

One of the primary objectives in molecular nanospintronics is to manipulate the spin states of organic molecules with a d-electron center, by suitable external means. In this Letter, we demonstrate by first principles density functional calculations, as well as second order perturbation theory, that a strain induced change of the spin state, from S=1→S=2, takes place for an iron porphyrin (FeP) molecule deposited at a divacancy site in a graphene lattice. The process is reversible in the sense that the application of tensile or compressive strains in the graphene lattice can stabilize FeP in different spin states, each with a unique saturation moment and easy axis orientation. The effect is brought about by a change in Fe-N bond length in FeP, which influences the molecular level diagram as well as the interaction between the C atoms of the graphene layer and the molecular orbitals of FeP.     

Phase field modeling of complex crack patterns in multi-physics problems

Recently developed continuum phase field models for brittle fracture show excellent modeling capability in situations with complex crack topologies including branching in the small and large strain applications. This work presents a generalization towards fully coupled multi-physics problems at large strains. A modular concept is outlined for the linking of the diffusive crack modeling with complex multi field material response, where the focus is put on the model problem of finite thermo-elasticity. This concerns a generalization of crack driving forces from the energetic definitions towards stress-based criteria, the constitutive modeling of degradation of non-mechanical fluxes on generated crack faces. Particular assumptions are made on the generation of convective heat exchanges approximating surface load integrals of the sharp crack approach by distinct volume integrals. The coupling effect is also shown in generation of cracks due to thermally induced stress states. We finally demonstrate the performance of the phase field formulation of fracture at large strains by means of representative numerical examples. (© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

β-Cyclodextrin carbon-based nanoparticles with a core-shell-shell structure for efficient adsorption of crystal violet and bisphenol A

Textile wastewater contains highly toxic,nondegradable,carcinogenic organic pollutants,causing severe damage to the ecological environment.In this work,β-cyclod...     

Groupwise dense families

We show that the Filter Dichotomy Principle implies that there are exactly four classes of ideals in the set of increasing functions from the natural numbers. We thus answer two open questions on consequences of ? < ?. We show that ? < ? implies that ? = ?, and that Filter Dichotomy together with ? < ? implies ? < ?. The technical means is the investigation of groupwise dense sets, ideals, filters and ultrafilters. With related techniques we prove the new inequality ?≤ cf(?). Received: 9 October 1998 / Revised version: 18 August 1999 / Published online: 21 December 2000